DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Erk7 and Srpk79D

DIOPT Version :9

Sequence 1:	NP_001188568.1	Gene:	Erk7 / 31877	FlyBaseID:	FBgn0052703	Length:	916	Species:	Drosophila melanogaster
Sequence 2:	NP_001246881.1	Gene:	Srpk79D / 40461	FlyBaseID:	FBgn0025702	Length:	1018	Species:	Drosophila melanogaster

Alignment Length:	601	Identity:	132/601 - (21%)
Similarity:	219/601 - (36%)	Gaps:	170/601 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 VESIFDVR----KRMGKGAYGIVWKATDRRTKNTVALKKVFDA-FRDETDAQRTYREVIFLRAFR 80
            :..|||.|    :::|.|.:..||...|.:.:..||||.|..| ...||.|.    |:..|.|.|
  Fly   339 IGDIFDNRFRVVRKLGWGHFSTVWLCRDLKDEKYVALKVVKSAPHYIETAAD----EIRLLEAIR 399

  Fly    81 -CHP------NIVRLVDIF--KASNNLDFYLVFEFMESDLHNVIKRGNV--LKDVHKRFVMYQLI 134
             ..|      .||||::.|  :..|.:...||||.:...|:.:|.:.|.  |.....|.::.|::
  Fly   400 DADPMDVKRERIVRLMNHFTVRGVNGMHTCLVFEALGCSLYKLIVKNNYQGLAIAQVRNIIRQVL 464

  Fly   135 NAIKFIHSG-NVIHRDLKPSNILIDSKCRLKVADFGLARTLSSRRIYDDLEQDGMLTDYVATRWY 198
            ..:.::||. ::||.|:||.|||:       |.|...|   .:::|.|::..       :..:..
  Fly   465 EGLDYLHSKCSIIHTDIKPENILL-------VIDNAAA---MNQQIDDEINS-------LRVKGV 512

  Fly   199 RAPEILVAS-RNYTKGIDMWGLGCILGEMIRQKPLFQ--GTSTVNQIEKIVTSLPNVTKLDIASI 260
            ..|:..::| ...||....|             ||.:  |::..|      |:..|.|..:..|.
  Fly   513 DFPDSYISSIEKQTKSRAKW-------------PLIEPNGSTNTN------TNTSNSTATNSNSS 558

  Fly   261 GPSFGSVLLSRNIQRDRRYSLDEMMKNCCDDGISLVKALLVLNPHNRLTAKEAIRHPYVSRFQYA 325
            .| ..:|::|         :||:      :|..:...:.|..|..:.|.:|            |:
  Fly   559 TP-LAAVIMS---------TLDK------EDTTTTTSSTLNSNTTSSLASK------------YS 595

  Fly   326 S--AEMDLHMDVVPPLKDHVRY------------DVDQYRNSLYELIDRET-SCSNRTVSNSTPS 375
            |  .:.:.:..:......:.||            |.|:         |.|: :...::...||..
  Fly   596 SLLGDSECNGGLGGSANINNRYRTEKKITAKSSGDCDE---------DAESDTLGEQSTLASTMD 651

  Fly   376 SNRDELPKPVRVTKQARTTSAKQPTTSPAERKKEPSSVE----------VTQSRKNIKLLGSAHK 430
            |..|..|:|   ...::..:..:|:..|...:..|:|..          :.:|:.|..:|.:...
  Fly   652 SPTDLDPEP---ELDSKPNTVPEPSEGPIPEQPTPNSTNSSCPSHNTATIAKSKINSNILSTCTS 713

  Fly   431 AQS-KEINHMESAITQVSIASAPPAAAPP---------------------APAATAPAVPRK--- 470
            ..| .|.....:..|..|..||||:|.|.                     ||:|||||....
  Fly   714 LTSTNEYCFTNTNTTTASTPSAPPSATPSSAPALASATPPSTCTPSFTQIAPSATAPATSTTCTT 778

  Fly   471 -----SGD---KSVPKCQHNNAAVQRELAAVAAAAAVARRK------KSSWQSQAQSQGKFHTEA 521
                 .||   .|......:||.............|:|:..      .|..|||: ||...:|
  Fly   779 SAEFYDGDHKTTSTSTTTTSNAISSATTTTATTTTAIAKLNVHANAIPSQNQSQS-SQNNTYT-- 840

  Fly   522 KAHVQTAIQTQKDNIK 537
               :|:.|......:|
  Fly   841 ---IQSLIDNSNVRVK 853

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Erk7	NP_001188568.1	STKc_MAPK15-like	17..358	CDD:270841	83/370 (22%)
Srpk79D	NP_001246881.1	STKc_SRPK	336..>504	CDD:271038	54/178 (30%)
		S_TKc	347..>492	CDD:214567	46/155 (30%)
		STKc_SRPK	<844..1012	CDD:271038	2/10 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24055
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100