DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Erk7 and Mapk15

DIOPT Version :9

Sequence 1:	NP_001188568.1	Gene:	Erk7 / 31877	FlyBaseID:	FBgn0052703	Length:	916	Species:	Drosophila melanogaster
Sequence 2:	XP_006241839.1	Gene:	Mapk15 / 286997	RGDID:	628675	Length:	583	Species:	Rattus norvegicus

Alignment Length:	508	Identity:	211/508 - (41%)
Similarity:	292/508 - (57%)	Gaps:	73/508 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 ELDQTVESIFDVRKRMGKGAYGIVWKATDRRTKNTVALKKVFDAFRDETDAQRTYREVIFLRAFR 80
            |:|:.|...:.:::|:|||||||||||.||||...||:||:||||||:||||||:||::.||.|.
  Rat     5 EVDRHVSQRYLIKRRLGKGAYGIVWKAMDRRTGEVVAIKKIFDAFRDQTDAQRTFREIMLLREFG 69

  Fly    81 CHPNIVRLVDIFKASNNLDFYLVFEFMESDLHNVIKRGNVLKDVHKRFVMYQLINAIKFIHSGNV 145
            .||||:||:|:..|.|:.|.|||||.|::||:.||::|.:|:|:|||.:.|||:.|.||||||.|
  Rat    70 GHPNIIRLLDVIPAKNDRDIYLVFESMDTDLNAVIQKGRLLEDIHKRCIFYQLLRATKFIHSGRV 134

  Fly   146 IHRDLKPSNILIDSKCRLKVADFGLARTLSSRRIYDDLEQDG--MLTDYVATRWYRAPEILVASR 208
            ||||.||:|:|:|:.||:|:.||||||:||     |..|..|  .||:|||||||||||:|::||
  Rat   135 IHRDQKPANVLLDAACRVKLCDFGLARSLS-----DFPEGPGGQALTEYVATRWYRAPEVLLSSR 194

  Fly   209 NYTKGIDMWGLGCILGEMIRQKPLFQGTSTVNQIEKIVTSLPNVTKLDIASIGPSFGSVLLSRNI 273
            .||.|:|||.||||||||:|.:|||.||||.:|:|.|:.::|..:..::..:|..: |.|:.:|:
  Rat   195 WYTPGVDMWSLGCILGEMLRGQPLFPGTSTFHQLELILETIPLPSMEELQGLGSDY-SALILQNL 258

  Fly   274 QRDRRYSLDEMM-KNCCDDGISLVKALLVLNPHNRLTAKEAIRHPYVSRFQYASAEMDLHMDVVP 337
            ....|.:||.:: .:...:.:.|:|.||...|..||:|::|::||||.||.....|.....||..
  Rat   259 GSRPRQTLDALLPPDTPPEALDLLKRLLAFAPDKRLSAEQALQHPYVQRFHCPDREWTRGSDVRL 323

  Fly   338 PLKDHVRYDVDQYRNSLYELI--DRETSCSNR---------------------------TVSNST 373
            |:.:..:....:|||.||::|  .|..|.|.|                           .|...|
  Rat   324 PVHEGDQLSAPEYRNRLYQMILERRRNSRSPREEDLGVVASRAELRASQRQSLKPGVLPQVLAET 388

  Fly   374 PSSNRDELPKP----------VRVTKQARTT--------SAKQPTTSPAERKKEPSSVEVTQSRK 420
            |:..|.  |||          |.|.:|:...        |.::|..:..|....||.|: |..|.
  Rat   389 PARKRG--PKPQNGHGHDPEHVEVRRQSSDPLYQLPPPGSGERPPGATGEPPSAPSGVK-THVRA 450

  Fly   421 NIKLLGSAHKAQSKEINHMESAITQVSIASAP-----PAAAPPAPAATAPAVP 468
            ....|.|...||         |..|..|.|.|     |.|......:.|||:|
  Rat   451 VAPSLTSQAAAQ---------AANQPLIRSDPARGGGPRAVGARRVSPAPALP 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Erk7	NP_001188568.1	STKc_MAPK15-like	17..358	CDD:270841	172/343 (50%)
Mapk15	XP_006241839.1	STKc_MAPK15-like	6..344	CDD:270841	172/343 (50%)
Mapk15	XP_006241839.1	S_TKc	14..305	CDD:214567	157/296 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335175
Domainoid	1	1.000	326	1.000	Domainoid score	I1159
eggNOG	1	0.900	-	-		E1_KOG0660
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H16371
Inparanoid	1	1.050	351	1.000	Inparanoid score	I2206
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D741207at2759
OrthoFinder	1	1.000	-	-		FOG0000164
OrthoInspector	1	1.000	-	-		oto96554
orthoMCL	1	0.900	-	-		OOG6_102994
Panther	1	1.100	-	-	LDO	PTHR24055
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X6365
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.760