DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Erk7 and Mapk7

DIOPT Version :9

Sequence 1:	NP_001188568.1	Gene:	Erk7 / 31877	FlyBaseID:	FBgn0052703	Length:	916	Species:	Drosophila melanogaster
Sequence 2:	NP_001277963.1	Gene:	Mapk7 / 23939	MGIID:	1346347	Length:	806	Species:	Mus musculus

Alignment Length:	619	Identity:	169/619 - (27%)
Similarity:	275/619 - (44%)	Gaps:	160/619 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 FDVRKRMGKGAYGIVWKATDRRTKNTVALKKVFDAFRDETDAQRTYREVIFLRAFRCHPNIVRLV 89
            :::.:.:|.||||:|..|..|.|...||:||:.:||...|:|:||.||:..|:.|: |.||:.:.
Mouse    55 YEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFK-HDNIIAIK 118

  Fly    90 DIFKAS----NNLDFYLVFEFMESDLHNVIKRGNVLKDVHKRFVMYQLINAIKFIHSGNVIHRDL 150
            ||.|.:    .....|:|.:.||||||.:|.....|...|.|:.:|||:..:|::||..||||||
Mouse   119 DILKPTVPYGEFRSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQLLRGLKYMHSAQVIHRDL 183

  Fly   151 KPSNILIDSKCRLKVADFGLARTLSSRRIYDDLEQDGMLTDYVATRWYRAPEILVASRNYTKGID 215
            ||||:|::..|.||:.|||:||.|.:    ...|....:|:|||||||||||::::...||:.||
Mouse   184 KPSNLLVNENCELKIGDFGMARGLCT----SPAEHQYFMTEYVATRWYRAPELMLSLHEYTQAID 244

  Fly   216 MWGLGCILGEMIRQKPLFQGTSTVNQIEKIVTSLPNVTKLDIASIGPSFGSVLLSRNIQRDRRY- 279
            :|.:|||.|||:.::.||.|.:.|:|::.|:..|...:...|.::|           .:|.|.|
Mouse   245 LWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQAVG-----------AERVRAYI 298

  Fly   280 -SL--------DEMMKNCCDDGISLVKALLVLNPHNRLTAKEAIRHPYVSRFQYASAEMDLHMDV 335
             ||        :.:........:||:..:|...|..|::|..|:|||:::::.    :.|...|.
Mouse   299 QSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFLAKYH----DPDDEPDC 359

  Fly   336 VPPLKDHVRYDVDQYRNSLYELIDRETSCSNRTVSNSTPSSNRDELPKPVRVTKQARTTSAKQPT 400
            .||      :|.         ..|||.....| :..:..:...|...:...:.:|.|...:.||.
Mouse   360 APP------FDF---------AFDREALTRER-IKEAIVAEIEDFHARREGIRQQIRFQPSLQPV 408

  Fly   401 TSPAERKKEPSSVEVTQSRKNIKLLGSAHKAQSKEINHMESAITQVSIASAPPAAAP-------- 457
            .|      ||...:|                   |:....:.....::.|.|||..|
Mouse   409 AS------EPVCPDV-------------------EMPSPWAPSGDCAMESPPPALPPCSDPAPDT 448

  Fly   458 ------PAPAATAPAVPRKSGDKSVPKCQHNNAAVQRELAAVAAAAAVARRKKSSWQSQAQSQGK 516
                  |||.|:..|.|::.|           |......||:.||
Mouse   449 VDLTLQPAPPASELAPPKREG-----------AISDNTKAALKAA-------------------- 482

  Fly   517 FHTEAKAHVQTAIQTQKDNIKDSPPRMIQESQSLTEAKAPIPKNRYSNKMCQEKKYKKKHHSMSC 581
                       .:::.:..::|.|...::         ||.|:...:   .||::.:::
Mouse   483 -----------LLKSLRSRLRDGPSAPLE---------APEPRKPVT---AQERQRERE------ 518

  Fly   582 ITRDTFPSETEHRQQREERAYQRQMKR-ELQLKE 614
                      |.|::|:|||.:|:.:| |.:.||
Mouse   519 ----------EKRRRRQERAKEREKRRQERERKE 542

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Erk7	NP_001188568.1	STKc_MAPK15-like	17..358	CDD:270841	120/346 (35%)
Mapk7	NP_001277963.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23
		Required for cytoplasmic targeting	2..77		8/21 (38%)
		STKc_ERK5	49..384	CDD:270842	124/364 (34%)
		Required for binding to MAP2K5	78..139		22/61 (36%)
		Necessary for oligomerization	140..406		96/300 (32%)
		TXY	219..221		1/1 (100%)
		May not be required for kinase activity, required to stimulate MEF2C activity	407..806		41/231 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	424..473		13/59 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	488..727		18/83 (22%)
		Nuclear localization signal	505..539		11/52 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0660
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D741207at2759
OrthoFinder	1	1.000	-	-		FOG0000164
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820