DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Erk7 and Mapk4

DIOPT Version :9

Sequence 1:	NP_001188568.1	Gene:	Erk7 / 31877	FlyBaseID:	FBgn0052703	Length:	916	Species:	Drosophila melanogaster
Sequence 2:	NP_766220.2	Gene:	Mapk4 / 225724	MGIID:	2444559	Length:	583	Species:	Mus musculus

Alignment Length:	495	Identity:	146/495 - (29%)
Similarity:	237/495 - (47%)	Gaps:	96/495 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 MGKGAYGIVWKATDRRTKNTVALKKVFDAFRDETDAQRTYREVIFLRAFRCHPNIVRLVDI---- 91
            :|.|..|:|..|||.|....||:||:  ...|....:...||:..:|... |.|||::.::
Mouse    26 LGFGVNGLVLSATDSRACRKVAVKKI--VLSDARSMKHALREIKIIRRLD-HDNIVKVYEVLGPK 87

  Fly    92 --------FKASNNLDFYLVFEFMESDLHNVIKRGNVLKDVHKRFVMYQLINAIKFIHSGNVIHR 148
                    ||.|   ..|:|.|:||:||..::::|.:.:| |.:..||||:..:|:|||.||:||
Mouse    88 GSDLQGELFKFS---VAYIVQEYMETDLACLLEQGTLTED-HAKLFMYQLLRGLKYIHSANVLHR 148

  Fly   149 DLKPSNILIDSK-CRLKVADFGLARTLSSRRIYDDLEQDGMLTDYVATRWYRAPEILVASRNYTK 212
            ||||:||.|.:: ..||:.||||||.:...     ....|.|::.:.|:|||:|.:|::..||||
Mouse   149 DLKPANIFISTEDLVLKIGDFGLARIVDQH-----YSHKGYLSEGLVTKWYRSPRLLLSPNNYTK 208

  Fly   213 GIDMWGLGCILGEMIRQKPLFQGTSTVNQIEKIVTSLPNV---TKLDIASIGPSFGSVLLSRNIQ 274
            .||||..||||.||:..|.||.|...:.|::.|:.::|.|   .|.::..:.|||  |..:..::
Mouse   209 AIDMWAAGCILAEMLTGKMLFAGAHELEQMQLILDTIPVVREEDKEELLRVMPSF--VSSTWEVK 271

  Fly   275 RDRRYSLDEMMKNCCDDGISLVKALLVLNPHNRLTAKEAIRHPYVSRFQYASAEMDLHMDVVPPL 339
            |..|    :::.:...:.|..::.:|..||.:||||:..::|||:|.:.....|         |.
Mouse   272 RPLR----KLLPDVNSEAIDFLEKILTFNPMDRLTAEMGLQHPYMSPYSCPEDE---------PT 323

  Fly   340 KDH---VRYDV----------------DQYRNSLYELID-RETSCSNRTVSNSTPSSNRDELPKP 384
            ..|   :..::                |:|..||...:: |...|.:.:.....|.:....|.:.
Mouse   324 SQHPFRIEDEIDDIVLMAASQSQLSNWDRYPVSLSSDLEWRPDRCQDASEVQRDPRAGSTPLAED 388

  Fly   385 VRV--TKQARTTSAK--QPTTSPAERKKE-------------PSSVEVTQSRKNIKLLGSAHKAQ 432
            |:|  .|.::::|.:  :.:.|..||..|             ||.::....|.|    ...|.::
Mouse   389 VQVDPRKDSQSSSERFLEQSHSSMERAFEADYGRSCDYKVGSPSYLDKLLWRDN----KPHHYSE 449

  Fly   433 SK---EINHMESAITQVSIASAPP---AAAPPAPAATAPA 466
            .|   :::|.:.|      |||||   .||.|......||
Mouse   450 PKLILDLSHWKQA------ASAPPRAAVAADPVSREDEPA 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Erk7	NP_001188568.1	STKc_MAPK15-like	17..358	CDD:270841	116/361 (32%)
Mapk4	NP_766220.2	STKc_MAPK4_6	14..351	CDD:143359	112/351 (32%)
		SEG motif	186..188		0/1 (0%)
		FRIEDE motif	328..333		0/4 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	366..410		7/43 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	495..531
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0660
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D741207at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910