Protein Alignment Erk7 and MAPK15

DIOPT Version :10

• Sequence 1: NP_727335.1
• Gene: Erk7 / 31877
• FlyBaseID: FBgn0052703
• Length: 916
• Species: Drosophila melanogaster
• Sequence 2: XP_011515227.1
• Gene: MAPK15 / 225689
• HGNCID: 24667
• Length: 565
• Species: Homo sapiens
• Alignment Length: 545
• Identity: 205/545 - (37%)
• Similarity: 304/545 - (55%)
• Gaps: 83/545 - (15%)

  Fly    35 AYGIVWKATDRRTKNTVALKKVFDAFRDETDA-------------------QRTYREVIFLRAFR 80
            ||||||||.||||...||:||:||||||:|||                   |||:||:..|:.|.
Human    25 AYGIVWKAVDRRTGEVVAIKKIFDAFRDKTDAQDMGFLLAPPTHTPVFLSLQRTFREITLLQEFG 89

  Fly    81 CHPNIVRLVDIFKASNNLDFYLVFEFMESDLHNVIKRGNVLKDVHKRFVMYQLINAIKFIHSGNV 145
            .||||:.|:|:.:|.|:.|.|||||||::||:.||::|.:|:|||.|.:.|||:.|.:|:|||:|
Human    90 DHPNIISLLDVIRAENDRDIYLVFEFMDTDLNAVIRKGGLLQDVHVRSIFYQLLRATRFLHSGHV 154

  Fly   146 IHRDLKPSNILIDSKCRLKVADFGLARTLSSRRIYDDL---EQDGMLTDYVATRWYRAPEILVAS 207
            :|||.||||:|:|:.|.:|:.||||||:|.      ||   .:|..:|:|||||||||||:|::|
Human   155 VHRDQKPSNVLLDANCTVKLCDFGLARSLG------DLPEGPEDQAVTEYVATRWYRAPEVLLSS 213

  Fly   208 RNYTKGIDMWGLGCILGEMIRQKPLFQGTSTVNQIEKIVTSLPNVTKLDIASIGPSFGSVLLSRN 272
            ..||.|:|||.||||||||:|.:|||.||||::|:|.|:.::|..::.|:.::|....:.:|.:.
Human   214 HRYTLGVDMWSLGCILGEMLRGRPLFPGTSTLHQLELILETIPPPSEEDLLALGSGCRASVLHQL 278

  Fly   273 IQRDRRYSLDEMM-KNCCDDGISLVKALLVLNPHNRLTAKEAIRHPYVSRFQYASAEMDLHMDVV 336
            ..|.|: :||.:: .:...:.:.|::.|||..|..||:|.:|::||||.||...|.|.....||.
Human   279 GSRPRQ-TLDALLPPDTSPEALDLLRRLLVFAPDKRLSATQALQHPYVQRFHCPSDEWAREADVR 342

  Fly   337 PPLKDHVRYDVDQYRNSLYELIDRETSCSNRTVSNSTP---SSNRDELPKPVRVTKQARTTSAKQ 398
            |...:.|:..|.:||:.:|::| .|...|:.|.....|   |.::..|.|| |...|..:.:..|
Human   343 PRAHEGVQLSVPEYRSRVYQMI-LECGGSSGTSREKGPEGVSPSQAHLHKP-RADPQLPSRTPVQ 405

  Fly   399 -----PTTSPAERKKEPSSVEVTQSRKNIKLLGSAHKAQSKEINHMESAITQVSIASAPPAAAPP 458
                 |.:||..   :|:..|..::.||:....||...|:..:.:.|.           |..|..
Human   406 GPRPRPQSSPGH---DPAEHESPRAAKNVPRQNSAPLLQTALLGNGER-----------PPGAKE 456

  Fly   459 APAATAPAVPRKSGDKSVPKCQHNNAAVQRELAAVAAAAAVARRKKSSWQSQAQSQGKFHTEAKA 523
            ||..|...| :.||..:.|.....            |||.||        :||..:|.::.....
Human   457 APPLTLSLV-KPSGRGAAPSLTSQ------------AAAQVA--------NQALIRGDWNRGGGV 500

  Fly   524 HVQTAIQTQKDNIKDSPPRMIQESQ 548
            .|.        :::..|||:..|::
Human   501 RVA--------SVQQVPPRLPPEAR 517

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Erk7	NP_727335.1	STKc_MAPK15-like	17..358	CDD:270841	160/345 (46%)
MAPK15	XP_011515227.1	STKc_MAPK15-like	25..364	CDD:270841	160/345 (46%)