DRSC/TRiP Functional Genomics Resources

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Protein Alignment Erk7 and Mapk7

DIOPT Version :10

Sequence 1:NP_727335.1 Gene:Erk7 / 31877 FlyBaseID:FBgn0052703 Length:916 Species:Drosophila melanogaster
Sequence 2:NP_001178476.1 Gene:Mapk7 / 114509 RGDID:621505 Length:812 Species:Rattus norvegicus


Alignment Length:619 Identity:168/619 - (27%)
Similarity:275/619 - (44%) Gaps:160/619 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    25 FDVRKRMGKGAYGIVWKATDRRTKNTVALKKVFDAFRDETDAQRTYREVIFLRAFRCHPNIVRLV 89
            :::.:.:|.||||:|..|..|.|...||:||:.:||...|:|:||.||:..|:.|: |.||:.:.
  Rat    55 YEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFK-HDNIIAIK 118

  Fly    90 DIFKAS----NNLDFYLVFEFMESDLHNVIKRGNVLKDVHKRFVMYQLINAIKFIHSGNVIHRDL 150
            ||.:.:    .....|:|.:.||||||.:|.....|...|.|:.:|||:..:|::||..||||||
  Rat   119 DILRPTVPYGEFRSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQLLRGLKYMHSAQVIHRDL 183

  Fly   151 KPSNILIDSKCRLKVADFGLARTLSSRRIYDDLEQDGMLTDYVATRWYRAPEILVASRNYTKGID 215
            ||||:|::..|.||:.|||:||.|.:    ...|....:|:|||||||||||::::...||:.||
  Rat   184 KPSNLLVNENCELKIGDFGMARGLCT----SPAEHQYFMTEYVATRWYRAPELMLSLHEYTQAID 244

  Fly   216 MWGLGCILGEMIRQKPLFQGTSTVNQIEKIVTSLPNVTKLDIASIGPSFGSVLLSRNIQRDRRY- 279
            :|.:|||.|||:.::.||.|.:.|:|::.|:..|...:...|.::|           .:|.|.| 
  Rat   245 LWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQAVG-----------AERVRAYI 298

  Fly   280 -SL--------DEMMKNCCDDGISLVKALLVLNPHNRLTAKEAIRHPYVSRFQYASAEMDLHMDV 335
             ||        :.:........:||:..:|...|..|::|..|:|||:::::.    :.|...|.
  Rat   299 QSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFLAKYH----DPDDEPDC 359

  Fly   336 VPPLKDHVRYDVDQYRNSLYELIDRETSCSNRTVSNSTPSSNRDELPKPVRVTKQARTTSAKQPT 400
            .||      :|.         ..|||.....| :..:..:...|...:...:.:|.|...:.||.
  Rat   360 APP------FDF---------AFDREALTRER-IKEAIVAEIEDFHARREGIRQQIRFQPSLQPV 408

  Fly   401 TSPAERKKEPSSVEVTQSRKNIKLLGSAHKAQSKEINHMESAITQVSIASAPPAAAP-------- 457
            .|      ||...:|                   |:....:.....::.|.|||..|        
  Rat   409 AS------EPVCPDV-------------------EMPSPWAPSGDCAMESPPPALPPCSGPAPDT 448

  Fly   458 ------PAPAATAPAVPRKSGDKSVPKCQHNNAAVQRELAAVAAAAAVARRKKSSWQSQAQSQGK 516
                  |||.|:..|.|::.|           |......||:.||                    
  Rat   449 VDLTLQPAPPASELAPPKREG-----------AISDNTKAALKAA-------------------- 482

  Fly   517 FHTEAKAHVQTAIQTQKDNIKDSPPRMIQESQSLTEAKAPIPKNRYSNKMCQEKKYKKKHHSMSC 581
                       .:::.:..::|.|...::         ||.|:...:   .||::.:::      
  Rat   483 -----------LLKSLRSRLRDGPSAPLE---------APEPRKPVT---AQERQRERE------ 518

  Fly   582 ITRDTFPSETEHRQQREERAYQRQMKR-ELQLKE 614
                      |.|::|:|||.:|:.:| |.:.||
  Rat   519 ----------EKRRRRQERAKEREKRRQERERKE 542

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Erk7NP_727335.1 STKc_MAPK15-like 17..358 CDD:270841 119/346 (34%)
Mapk7NP_001178476.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..23
Required for cytoplasmic targeting. /evidence=ECO:0000250 2..77 8/21 (38%)
STKc_ERK5 49..384 CDD:270842 123/364 (34%)
Required for binding to MAP2K5. /evidence=ECO:0000250 78..139 21/61 (34%)
Necessary for oligomerization. /evidence=ECO:0000250 140..406 96/300 (32%)
TXY. /evidence=ECO:0000250 219..221 1/1 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 424..475 13/61 (21%)
Nuclear localization signal. /evidence=ECO:0000250 505..539 11/52 (21%)
Blue background indicates that the domain is not in the aligned region.

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