DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Erk7 and nlk

DIOPT Version :9

Sequence 1:	NP_001188568.1	Gene:	Erk7 / 31877	FlyBaseID:	FBgn0052703	Length:	916	Species:	Drosophila melanogaster
Sequence 2:	NP_001116885.1	Gene:	nlk / 100144638	XenbaseID:	XB-GENE-483544	Length:	534	Species:	Xenopus tropicalis

Alignment Length:	491	Identity:	141/491 - (28%)
Similarity:	227/491 - (46%)	Gaps:	132/491 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 HAQERRIQELDQTVESIFDVRKRMGKGAYGIVWKATDRRTKNTVALKKVFDAFRDETDAQRTYRE 72
            |......|:||      .:..:.:|.||:|:||..||.|....|||||:.:.|::....:|.:||
Frog   134 HQHSHHAQQLD------IEPDRPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRE 192

  Fly    73 VIFLRAFRCHPNIVRLVDIFKASNNLDF----YLVFEFMESDLHNVIKRGNVLKDVHKRFVMYQL 133
            :..|..|: |.|::..:||.:.. ::|:    |:|.|.|:||||.:|.....|...|.:..:||:
Frog   193 LKMLCFFK-HDNVLSALDILQPP-HIDYFEEIYVVTELMQSDLHKIIVSPQPLSSDHVKVFLYQI 255

  Fly   134 INAIKFIHSGNVIHRDLKPSNILIDSKCRLKVADFGLARTLSSRRIYDDLEQDGMLTDYVATRWY 198
            :..:|::||..::|||:||.|:|::|.|.||:.||||||.       ::|::...:|..|.|::|
Frog   256 LRGLKYLHSAGILHRDIKPGNLLVNSNCVLKICDFGLARV-------EELDESRHMTQEVVTQYY 313

  Fly   199 RAPEILVASRNYTKGIDMWGLGCILGEMIRQKPLFQGTSTVNQIEKIVTSL---PNVTKLDIASI 260
            ||||||:.||:||..||:|.:|||..|::.::.|||..|.:.|:: ::|.|   |::..:..|..
Frog   314 RAPEILMGSRHYTNAIDVWSVGCIFAELLGRRILFQAQSPIQQLD-LITDLLGTPSLEAMRTACE 377

  Fly   261 G------------PSFGSVLLSRNIQRDRRYSLDEMMKNCCDDGISLVKALLVLNPHNRLTAKEA 313
            |            ||. .||          |:|.....:   :.:.|:..:||.:|..|::||:|
Frog   378 GAKAHILRGPHKQPSL-PVL----------YTLSSQATH---EAVHLLCRMLVFDPSKRISAKDA 428

  Fly   314 IRHPYVSRFQYASAEMDLHMDVVPPLKDHVRYDVDQYRNSLYELIDRETSCSNRTVSNSTPSSNR 378
            :.|||:.                   :..:||.....:            |...|.|.
Frog   429 LAHPYLD-------------------EGRLRYHTCMCK------------CCFSTSSG------- 455

  Fly   379 DELPKPVRVTKQARTTSAKQPTTSPAERKKEPSSVEVTQSRKNIKLLGSAHKAQSKEINHM---- 439
                   ||     .||..:|.|:|    |...:.|     ||:..:     .|.|||.|.
Frog   456 -------RV-----YTSDFEPITNP----KFDDTFE-----KNLSSV-----RQVKEIIHQFILE 494

  Fly   440 -------------ESAITQVSIAS--APPAAAPPAP 460
                         :||..:..|:|  |.|:..||:|
Frog   495 QQKGNRVPLCINPQSAAFKSFISSTVAQPSEMPPSP 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Erk7	NP_001188568.1	STKc_MAPK15-like	17..358	CDD:270841	111/359 (31%)
nlk	NP_001116885.1	STKc_NLK	144..515	CDD:173748	131/464 (28%)
nlk	NP_001116885.1	S_TKc	146..434	CDD:214567	106/311 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D741207at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010