DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Erk7 and mapk13

DIOPT Version :9

Sequence 1:	NP_001188568.1	Gene:	Erk7 / 31877	FlyBaseID:	FBgn0052703	Length:	916	Species:	Drosophila melanogaster
Sequence 2:	XP_001337833.2	Gene:	mapk13 / 100002318	ZFINID:	ZDB-GENE-041111-17	Length:	362	Species:	Danio rerio

Alignment Length:	389	Identity:	126/389 - (32%)
Similarity:	196/389 - (50%)	Gaps:	58/389 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 ERRI----QELDQTVESI---FDVRKRMGKGAYGIVWKATDRRTKNTVALKKVFDAFRDETDAQR 68
            |.|:    :|::.||..:   :...|::|.||||.|..:.:.:||..||:||:...|:.|..|:|
Zfish     2 ESRVEFSREEINSTVWEVPAKYVCLKQIGTGAYGSVCSSINNKTKEKVAIKKLHRPFQSEIFAKR 66

  Fly    69 TYREVIFLRAFRCHPNIVRLVDIFKASNNL----DFYLVFEFMESDLHNVIKRGNVLKDVHKRFV 129
            .|||:..|:..: |.|::.|:|:|..:..|    |||||..:|.:||..|  :|.:.:| ..:|:
Zfish    67 AYRELRLLKHMK-HENVIGLLDVFTPATRLDEFQDFYLVMPYMYTDLSKV--KGLLTED-RIQFL 127

  Fly   130 MYQLINAIKFIHSGNVIHRDLKPSNILIDSKCRLKVADFGLARTLSSRRIYDDLEQDGMLTDYVA 194
            :||::..:|:||...:|||||||.|:.::..|.||:.||||||           ..|..:|.||.
Zfish   128 VYQMLCGLKYIHGAGIIHRDLKPGNLAVNQDCELKILDFGLAR-----------HTDAEMTGYVV 181

  Fly   195 TRWYRAPEILVASRNYTKGIDMWGLGCILGEMIRQKPLFQGTSTVNQIEKI--VTSLPNVTKLDI 257
            ||||||||:::...:||:.:|:|.:|||:|||...|.||:|...::|:.:|  |...|
Zfish   182 TRWYRAPEVILNWMHYTQTVDIWSVGCIMGEMFNGKTLFKGKDYMDQLTQIMKVAGTP------- 239

  Fly   258 ASIGPSFGSVLLS-------RNIQRDRRYSLDEMMKNCCDDGISLVKALLVLNPHNRLTAKEAIR 315
               ||.|...|.|       |::..........:........:.|::.:|||:...||||..|:.
Zfish   240 ---GPEFVEKLESPEAKSYVRSLPHYPHRDFSTLFPRASKKAVELLEKMLVLDADARLTASGALA 301

  Fly   316 HPYVSRFQYASAEMDLHMDVVPPLKDHVRYDVDQYRNSLYELIDRETSCSNRTVSNSTPSSNRD 379
            |.|....:        ..|..|   :...|| |.|.|:...| :.....|.:.|.:..|...||
Zfish   302 HSYFDGLR--------DPDDWP---EPTAYD-DSYDNATLPL-EEWKRLSFKEVRSFVPFPRRD 352

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Erk7	NP_001188568.1	STKc_MAPK15-like	17..358	CDD:270841	117/356 (33%)
mapk13	XP_001337833.2	PKc_like	7..347	CDD:304357	121/377 (32%)
mapk13	XP_001337833.2	S_TKc	23..305	CDD:214567	107/306 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0660
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D324618at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910