DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31454 and TMEM135

DIOPT Version :9

Sequence 1:	NP_731250.1	Gene:	CG31454 / 318744	FlyBaseID:	FBgn0051454	Length:	455	Species:	Drosophila melanogaster
Sequence 2:	NP_075069.3	Gene:	TMEM135 / 65084	HGNCID:	26167	Length:	458	Species:	Homo sapiens

Alignment Length:	471	Identity:	142/471 - (30%)
Similarity:	231/471 - (49%)	Gaps:	36/471 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAAQSKLAEAAYKCSCQEFVHPWTSSCACATAGMLLSLIPGTFKTYSMVYMLALLMRRRIPSLKD 65
            |||.||    :...:|.|..|.|..||..:...:....:..:.|.|:.:|::|.::|:|.....
Human     1 MAALSK----SIPHNCYEIGHTWHPSCRVSFLQITGGALEESLKIYAPLYLIAAILRKRKLDYY- 60

  Fly    66 LGRTLASTLQSTAFLSLNGSLFVLAICLVRQFLGGFYFATAAWLPALLVSSISLAVERPQRRAPL 130
            |.:.|...|||.:||:.||:|::...|::|:.||.||..|..:..||..|.:::.:||..||..|
Human    61 LHKLLPEILQSASFLTANGALYMAFFCILRKILGKFYSWTPGFGAALPASYVAILIERKSRRGLL 125

  Fly   131 ALYVANVGIETLWKMLEARGLVRSIAKGQVLIMGASITALMYLY----RAGLHRTVAKDATFKGL 191
            .:|:||:..|||::|..|||.:.::..|:||:.  .|||.||::    :.||     |..||..|
Human   126 TIYMANLATETLFRMGVARGTITTLRNGEVLLF--CITAAMYMFFFRCKDGL-----KGFTFSAL 183

  Fly   192 GLIIGREE--EGPLKPSTVII------------PQRSNLGSLNFRCITSYLKVYNHLTTLRHPCC 242
            ..|:|:||  .....|.....            |.|.|:..|..:.:.|..|   |  ..||.||
Human   184 RFIVGKEEIPTHSFSPEAAYAKVEQKREQHEEKPGRMNMIGLVRKFVDSICK---H--GPRHRCC 243

  Fly   243 PH-QFGCAVYALLGGVKPFLGGVGVQVGFKLLLNITRILQQKMEWRKQIFNKGSLQLGLALGIFS 306
            .| :..|..|.:.|.::.|..|..:|...::......:..|........:||.:.|||..||.|.
Human   244 KHYEDNCISYCIKGFIRMFSVGYLIQCCLRIPSAFRHLFTQPSRLLSLFYNKENFQLGAFLGSFV 308

  Fly   307 LLFKMSSCGLRHSFGYDNALFAIQSGLIGSFGLLHFPNTTVSLYLMLKSLQLLYNWGVAEEKVPE 371
            .::|.:||.||.....|:.|.||.:|.:....::.:.:||:|:||..|.::.:|..|:...|||.
Human   309 SIYKGTSCFLRWIRNLDDELHAIIAGFLAGISMMFYKSTTISMYLASKLVETMYFKGIEAGKVPY 373

  Fly   372 VPHFSMIMYGFFTAVLCHSTVLEAKSMRPSYFKFIENISGGRLSRFNMKSFEAFGVKSQDQANYI 436
            .||...|:|...||:...:.|:|.:::||||:||:..::.|:.:..|.|..:.||..:.......
Human   374 FPHADTIIYSISTAICFQAAVMEVQTLRPSYWKFLLRLTKGKFAVMNRKVLDVFGTGASKHFQDF 438

  Fly   437 IKKLGIVKSSSNPLFP 452
            |.:|....::..|..|
Human   439 IPRLDPRYTTVTPELP 454

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31454	NP_731250.1	TMEM135_C_rich	15..145	CDD:292604	43/129 (33%)
TMEM135	NP_075069.3	TMEM135_C_rich	9..142	CDD:292604	44/133 (33%)
TMEM135	NP_075069.3	Tim17	249..>338	CDD:280604	25/88 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144500
Domainoid	1	1.000	87	1.000	Domainoid score	I7989
eggNOG	1	0.900	-	-		E1_KOG1398
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11295
Inparanoid	1	1.050	225	1.000	Inparanoid score	I3508
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49433
OrthoDB	1	1.010	-	-		D378483at33208
OrthoFinder	1	1.000	-	-		FOG0004145
OrthoInspector	1	1.000	-	-		otm41501
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12459
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3968
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.960