Protein Alignment ric8a and RIC8B

DIOPT Version :10

• Sequence 1: NP_572550.2
• Gene: ric8a / 31874
• FlyBaseID: FBgn0028292
• Length: 573
• Species: Drosophila melanogaster
• Sequence 2: NP_001317074.1
• Gene: RIC8B / 55188
• HGNCID: 25555
• Length: 560
• Species: Homo sapiens
• Alignment Length: 601
• Identity: 192/601 - (31%)
• Similarity: 308/601 - (51%)
• Gaps: 79/601 - (13%)

  Fly     2 ETEHLKRLEAKEADHIPAILDEFNTKNADLLVFDSFRTDNLWHELWLAIFGILDDQRLSHLHTQC 66
            |...|..:.|.||..|..:|.:::.|:.....|:|...|.. .:|...||.:|.....:.....|
Human     3 EERALYIVRAGEAGAIERVLRDYSDKHRATFKFESTDEDKR-KKLCEGIFKVLIKDIPTTCQVSC 66

  Fly    67 LNTVRILTRDEFSLQTNYIEQEVNTLLKLARIEAGSLKLPATPDELKQEEREEPQLEPSQAQSEV 131
            |..:|||:||:..|.....::.:..||:||       ||....|.|::           .::..|
Human    67 LEVLRILSRDKKVLVPVTTKENMQILLRLA-------KLNELDDSLEK-----------VSEFPV 113

  Fly   132 IAEALKCLCNLVYQSSDCRRQCLRQHCLDAILKRVASSMRHPCA-------LEYYDMKLLFLLTA 189
            |.|:||||||:|:.|     |..:|..|:..|.....::...|.       ::.:|::|||||:.
Human   114 IVESLKCLCNIVFNS-----QMAQQLSLELNLAAKLCNLLRKCKDRKFINDIKCFDLRLLFLLSL 173

  Fly   190 LEPAARSRLQIDLNGLTYMT---------KWLDDKLGEDSV-------GEEQLNIICELLKVMFN 238
            |....||:|:.:|.||..:|         ||.|:.  |.::       ..::.:...|.||.:||
Human   174 LHTDIRSQLRYELQGLPLLTQILESAFSIKWTDEY--ESAIDHNGPPLSPQETDCAIEALKALFN 236

  Fly   239 VTSAPDKSPNEYEIQSLH-LTGVLRELLLRFGDLATEKDRAVVTHAINLLTNISGSCLTELTLRC 302
            ||....|...|.:..... :..|||..||..|. ..:|...:.::|:|||:|:..|||..|....
Human   237 VTVDSWKVHKESDSHQFRVMAAVLRHCLLIVGP-TEDKTEELHSNAVNLLSNVPVSCLDVLICPL 300

  Fly   303 SNA----------ELESHKEREQDNEKEKDTEAGAGAKPRECCSQCFEKRNVRSLDVLLRYLRQS 357
            ::.          ||.|:|..|::...:.:|             ..:...|:.::.|||.::.:.
Human   301 THEETAQEATTLDELPSNKTAEKETVLKNNT-------------MVYNGMNMEAIHVLLNFMEKR 352

  Fly   358 LAQQEAEASSHELLSPVLTVLVKCARSDRVMRHYLRQEILPPLRDVSQRPEVGQELRNHLCRFLT 422
            :   :..:|..|.|:|||::|.:|:|:.|.:|.:|:.::|||||||:.|||||..:||.|.|.:|
Human   353 I---DKGSSYREGLTPVLSLLTECSRAHRNIRKFLKDQVLPPLRDVTNRPEVGSTVRNKLVRLMT 414

  Fly   423 LPAMILRDLSAELLFVLCKENVGRMIKYTGYGNAAGLFAKRGILDCRRVEGTDYSSDSEDSDTEE 487
            ...:.::.::||.|||||||.|..::|||||||||||.|.||:|...|  |.::.|:.||:||||
Human   415 HVDLGVKQIAAEFLFVLCKERVDSLLKYTGYGNAAGLLAARGLLAGGR--GDNWYSEDEDTDTEE 477

  Fly   488 YKQQQQGINPVLGCVEPRSKSHLDDISEEQKEYEAMQLVNLIEQLRQGGIVKPAMIDKDGRPQPL 552
            ||..:..||.:.|.:|....:.:|:::|||||||||:|||::::|.:..::||..:..||...||
Human   478 YKNAKPNINLITGHLEEPMPNPIDEMTEEQKEYEAMKLVNMLDKLSREELLKPMGLKPDGTITPL 542

  Fly   553 EHILQLQEELPQQQLD 568
            |..|.....:.:...|
Human   543 EEALNQYSVIEETSSD 558

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ric8a	NP_572550.2	Ric8	66..534	CDD:462973	168/501 (34%)
RIC8B	NP_001317074.1	Ric8	66..525	CDD:462973	168/502 (33%)