DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17754 and Klhl1

DIOPT Version :9

Sequence 1:	NP_572549.2	Gene:	CG17754 / 31873	FlyBaseID:	FBgn0030114	Length:	654	Species:	Drosophila melanogaster
Sequence 2:	NP_444335.2	Gene:	Klhl1 / 93688	MGIID:	2136335	Length:	751	Species:	Mus musculus

Alignment Length:	611	Identity:	328/611 - (53%)
Similarity:	423/611 - (69%)	Gaps:	13/611 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSAVNQKESPSRDSTASTSGHISMLADNTLESLSRDYSLGSLNSAGSQDEFFRCRDHADNILKRM 65
            :..:..:.:.|..:|....||   ...:|..||:....|.|    .|.:||::...||:...::|
Mouse   148 LKELQAEPASSIQATGEGCGH---RLTSTNHSLTPQSDLDS----SSSEEFYQAVHHAEQSFRKM 205

  Fly    66 QLYVDSQQLCDVVLIAGIDGKRVPAHRLVLSASSAYFSAMFTGSLRETKEQEVTLGEVHGDALHL 130
            :.|:..||||||:||.|  .:::||||||||:.|.||:||||..:.|.|::|:.:..:..:||..
Mouse   206 ENYLKQQQLCDVILIVG--NRKIPAHRLVLSSVSDYFAAMFTSDVCEAKQEEIKMEGIDPNALWD 268

  Fly   131 LVQYCYTGFIEMREDTVETLLATACLLQLNAVVTACCNFLARQLHPSNCLGFAFFAEQQSCTTLL 195
            |||:.|||.:|::|||:|.|||.||||||..||..||:||.:.||||||||...||:.|.|..|:
Mouse   269 LVQFAYTGCLELKEDTIENLLAAACLLQLPQVVEVCCHFLMKLLHPSNCLGIRAFADAQGCIELM 333

  Fly   196 RLAQAYTCQYFMQVCQNQEFFQLNADQLGKLLSSDDLNVPSEQDVFHSLMSWVRHDSAAREQHIP 260
            ::|.:||.:..|:|.:||||..|.|::|.|||:|||:|||.|:.:||:||.||::|...|...:.
Mouse   334 KVAHSYTMENIMEVIRNQEFLLLPAEELHKLLASDDVNVPDEETIFHALMMWVKYDMQRRCSDLS 398

  Fly   261 ELLALVRLPLLQPAFIMDHVENVC---NANECQQLVMEAFKWHLMPERRSRIATERTTPRKSTVG 322
            .|||.:|||||.|..:.| :||..   |..|||:|::||.|:||:||||:.:.:.||.|||||||
Mouse   399 MLLAFIRLPLLPPQILAD-LENHALFKNDLECQKLILEAMKYHLLPERRTLMQSPRTKPRKSTVG 462

  Fly   323 RLLAVGGMDAHKGAISIESYCPRLDKWTPWKHMTGRRLQFGAAVMEDKLILVGGRDGLKTLNTVE 387
            .|.||||||.:|||.:||.|..|.:.|.....|.|||||||.||::|||.::|||||||||||||
Mouse   463 TLYAVGGMDNNKGATTIEKYDLRTNLWIQAGMMNGRRLQFGVAVIDDKLFVIGGRDGLKTLNTVE 527

  Fly   388 SLDLNTMAWAPLNAMATPRHGLGVAVLEGPLYAVGGHDGWSYLNTVERWDPIARTWSYVAPMSSM 452
            ..:..|..|..|..|:|.||||||.|||||:||||||||||||||||||||.::.|:|||.||..
Mouse   528 CYNPKTKTWTVLPPMSTHRHGLGVTVLEGPIYAVGGHDGWSYLNTVERWDPQSQQWTYVASMSIA 592

  Fly   453 RSTAGVAVLGGRLYAVGGRDGSVCHRSIECYDPHTNKWSLLAPMNRRRGGVGVTVANGFLYALGG 517
            |||.|||.|.|:||:|||||||.|..|:|.|||||||||:.|||.:|||||||...:|||||:||
Mouse   593 RSTVGVAALNGKLYSVGGRDGSSCLSSMEYYDPHTNKWSMCAPMCKRRGGVGVATCDGFLYAVGG 657

  Fly   518 HDCPASNPMVCRTETVERYDPATDTWTLICSLALGRDAIGCALLGDRLIVVGGYDGNHALKSVEE 582
            ||.||||......:.||||||.|||||::..|::.|||:|..||||||..||||||...|.::|.
Mouse   658 HDAPASNHCSRLLDYVERYDPKTDTWTMVAPLSMPRDAVGVCLLGDRLYAVGGYDGQTYLNTMES 722

  Fly   583 YDPVRNGWNELAPMAFARAGACVVAI 608
            |||..|.|.::|.:...|||||||.|
Mouse   723 YDPQTNEWTQMASLNIGRAGACVVVI 748

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17754	NP_572549.2	BTB	70..170	CDD:279045	53/99 (54%)
		PHA03098	71..591	CDD:222983	302/522 (58%)
		BACK	179..281	CDD:285009	48/101 (48%)
		Kelch	323..369	CDD:128874	25/45 (56%)
		KELCH repeat	359..402	CDD:276965	26/42 (62%)
		Kelch	370..416	CDD:128874	28/45 (62%)
		KELCH repeat	406..449	CDD:276965	35/42 (83%)
		Kelch	418..463	CDD:128874	33/44 (75%)
		KELCH repeat	453..497	CDD:276965	31/43 (72%)
		Kelch	464..510	CDD:128874	31/45 (69%)
		Kelch_1	499..546	CDD:279660	31/46 (67%)
		KELCH repeat	500..549	CDD:276965	30/48 (63%)
		KELCH repeat	553..596	CDD:276965	24/42 (57%)
		Kelch	564..610	CDD:128874	24/45 (53%)
Klhl1	NP_444335.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	25..54
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	69..98
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	157..184		7/29 (24%)
		BTB	205..308	CDD:279045	55/104 (53%)
		PHA03098	209..731	CDD:222983	302/524 (58%)
		BACK	317..416	CDD:285009	47/98 (48%)
		Kelch 1	463..509		25/45 (56%)
		Kelch	464..509	CDD:128874	25/44 (57%)
		Kelch_1	498..543	CDD:279660	27/44 (61%)
		KELCH repeat	499..542	CDD:276965	26/42 (62%)
		Kelch 2	510..556		28/45 (62%)
		KELCH repeat	546..590	CDD:276965	35/43 (81%)
		Kelch	558..603	CDD:128874	33/44 (75%)
		Kelch 3	558..603		33/44 (75%)
		KELCH repeat	593..636	CDD:276965	30/42 (71%)
		Kelch	604..650	CDD:128874	31/45 (69%)
		Kelch 4	604..650		31/45 (69%)
		KELCH repeat	640..690	CDD:276965	30/49 (61%)
		Kelch	652..703	CDD:128874	29/50 (58%)
		Kelch 5	652..703		29/50 (58%)
		KELCH repeat	693..737	CDD:276965	24/43 (56%)
		Kelch 6	704..750		24/45 (53%)
		Kelch	704..748	CDD:128874	23/43 (53%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	119	1.000	Domainoid score	I5775
eggNOG	1	0.900	-	-		E1_KOG4441
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	688	1.000	Inparanoid score	I696
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48972
OrthoDB	1	1.010	-	-		D312716at33208
OrthoFinder	1	1.000	-	-		FOG0000036
OrthoInspector	1	1.000	-	-		otm44241
orthoMCL	1	0.900	-	-		OOG6_104433
Panther	1	1.100	-	-	O	PTHR24412
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.840