Protein Alignment CG17754 and klhl22

DIOPT Version :10

• Sequence 1: NP_572549.2
• Gene: CG17754 / 31873
• FlyBaseID: FBgn0030114
• Length: 654
• Species: Drosophila melanogaster
• Sequence 2: XP_012821754.1
• Gene: klhl22 / 780372
• XenbaseID: XB-GENE-948974
• Length: 671
• Species: Xenopus tropicalis
• Alignment Length: 629
• Identity: 174/629 - (27%)
• Similarity: 287/629 - (45%)
• Gaps: 49/629 - (7%)

  Fly    17 STSGHISMLADNTLESLSRDYSLGSLNSAGSQ-------DEFFRCRDHADNILKRMQLYVDSQQL 74
            |:...:|.:....|.:::.|......:.|..|       .:.:|..:|:..:|..:....||..|
 Frog    15 SSGSAVSFVPKGFLPAMAEDLETMKPSQAPQQPSLPQGSSKTYRSAEHSQALLSGLVALRDSGIL 79

  Fly    75 CDVVLIAGIDGKRVPAHRLVLSASSAYFSAMFTGSLRETKEQEVTLGEVHGDALHLLVQYCYTGF 139
            .||||  .::||.:.|||::|:||..||..||.|.|:|..::||.:..|...|:..::.:.||..
 Frog    80 FDVVL--KVEGKSIEAHRILLAASCDYFRGMFAGGLKEMDQREVQIHGVSYSAMCRIMDFIYTSD 142

  Fly   140 IEMREDTVETLLATACLLQLNAVVTACCNFLARQLHPSNCLGFAFFAEQQSCTTLLRLAQAYTCQ 204
            :.:..:.|:..|..||.||::.|:..||:||...:...|.|.....|:......|......:..:
 Frog   143 LALSVNNVQETLTAACQLQISEVIQFCCDFLVSWVDEENVLELYKLADIFHLNRLTEQLDTFVLK 207

  Fly   205 YFMQVCQNQEFFQLNADQLGKLLSSDDLNVPSEQDVFH-SLMSWVRHDSAAREQ----HIPELLA 264
            .|:...|.|.:.||..|::..||:|:.|.|.||.:|:. :|:.....:...::|    ..|:||.
 Frog   208 NFITFSQTQMYRQLPLDKVFSLLNSNRLEVASENEVYEGALLYHYTPEQLEKDQVSLLESPKLLE 272

  Fly   265 LVRLPLLQPAFIMDHVENVCNANECQQLVMEAFKWHLMPERRSRIATERTTPRKSTVGRLLAVGG 329
            .||.||:..| |:..:.:.......:..|::|.::| ..|....:.....|..:|....::..||
 Frog   273 AVRFPLMDLA-ILQRLHDKLGLCPLKTTVLKALEYH-KNESMQPVMQGPNTQLRSEFHCVVGFGG 335

  Fly   330 MDAHKGAI---SIESYCPRLDKWTPWKHMTG----RRLQFGAAVMEDKLILVGGRD---GLKTLN 384
            |.:....:   .::...|.|.:|.|   :|.    |....|.||:.:.:.|:||.:   |.:...
 Frog   336 MYSAPYTVLSDQVKYLNPLLGEWRP---LTAPHAPRMSNQGIAVLNNFVYLIGGDNNVRGYRAEA 397

  Fly   385 TVESLDLNTMAWAPLNAMATPRHGLGVAVLEGPLYAVGGHDGWSYLNTVERWDPIARTWSYVAPM 449
            .....|.....|..:.:|..||..|.|.||...||||.|.|....|..|||:||...||.||||:
 Frog   398 RCWRYDPRHSRWFQIQSMQQPRADLSVCVLGDFLYAVAGRDYHDELKEVERYDPFTNTWEYVAPL 462

  Fly   450 SSMRSTAGVAVLGGRLYAVGGRDGSVCHRSIECYDPHTNKWSLLAPMNRRRGGVGVTVANGFLYA 514
            .........|.|.||:|...||.|:...:...||||..::|:.:|....||...|:......:|.
 Frog   463 QKQVHAHAAAALDGRMYVACGRRGNTYLKDTFCYDPERDQWASVALSPVRRAWHGMAALQEKIYL 527

  Fly   515 LGGHDCPASNPMVCRTETVE--RYDPATDTWTLICSLALGRDAIGCALLGDRLIVVGGYDGNHAL 577
            :||    :::....|.:.:|  .|.|.||.|||:..|..|....|.|:|..::.|:||...|...
 Frog   528 IGG----SNDDEGFRQDVLEVACYSPKTDQWTLVSPLPAGHGEPGIAVLAKKIFVLGGRSHNQGD 588

  Fly   578 KS--VEEYDPVRNGW-------NELAPMAFARAGACVVAIPNVI 612
            ::  |..|:..|:.|       ::::.||     |||:.:|..:
 Frog   589 RTDYVHVYEAERDYWEDGPRLEDDISGMA-----ACVLTLPRSV 627

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG17754	NP_572549.2	PHA03098	71..591	CDD:222983	158/545 (29%)
		KELCH repeat	359..402	CDD:276965	9/45 (20%)
		KELCH repeat	406..449	CDD:276965	22/42 (52%)
		KELCH repeat	453..497	CDD:276965	14/43 (33%)
		KELCH repeat	500..549	CDD:276965	14/50 (28%)
		KELCH repeat	553..596	CDD:276965	11/51 (22%)
klhl22	XP_012821754.1	BTB_POZ_KLHL22	57..181	CDD:349560	42/125 (34%)
		PHA03098	82..604	CDD:222983	154/532 (29%)
		BACK_KLHL22	177..280	CDD:350536	27/102 (26%)
		KELCH repeat	324..364	CDD:276965	9/42 (21%)
		KELCH repeat	370..415	CDD:276965	9/44 (20%)
		KELCH repeat	419..463	CDD:276965	23/43 (53%)
		KELCH repeat	466..507	CDD:276965	13/40 (33%)
		KELCH repeat	513..561	CDD:276965	14/51 (27%)
		KELCH repeat	564..609	CDD:276965	11/44 (25%)