DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG17754 and klhl25

DIOPT Version :9

Sequence 1:	NP_572549.2	Gene:	CG17754 / 31873	FlyBaseID:	FBgn0030114	Length:	654	Species:	Drosophila melanogaster
Sequence 2:	NP_001072541.1	Gene:	klhl25 / 779996	XenbaseID:	XB-GENE-964636	Length:	589	Species:	Xenopus tropicalis

Alignment Length:	604	Identity:	179/604 - (29%)
Similarity:	277/604 - (45%)	Gaps:	80/604 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 SLGSLNSAGSQDEFFRCRDHADNILKRMQLYVDSQQLCDVVLIAGIDGKRVPAHRLVLSASSAYF 102
            |.||:|.:     .:....|:|.:|..:......:...||.|.||  .:..|.||.||:|.|.||
Frog    14 STGSMNIS-----LYHKLSHSDCVLNHLNTMRKQRLFTDVTLWAG--NRSFPCHRAVLAACSQYF 71

  Fly   103 SAMFTGSLRETKEQEVTLGE-VHGDALHLLVQYCYTGFIEMREDTVETLLATACLLQLNAVVTAC 166
            .|||:..|||:.:..|...: :|.:.|.||:.:.|:..|.:.|:..|:||....:||.:.:..|.
Frog    72 EAMFSNGLRESLDNTVNFHDSLHPEVLELLLDFAYSSKIIINEENAESLLEAGDMLQFHDIRDAA 136

  Fly   167 CNFLARQLHPSNCLGFAFFAEQQSCTTLLRLAQAYTCQYFMQVCQNQEFFQLNADQLGKLLSSDD 231
            |.||.:.|:||||||....::...|..|..|:.......|..:...::|..|:.|.:..|:|||:
Frog   137 CEFLEKNLYPSNCLGMMILSDAHQCQRLYELSLRTCLSNFATLHNTEDFCSLSKDMVLDLISSDE 201

  Fly   232 LNVPSEQDVFHSLMSWVRHDSAAREQHIPELLALVRLPLLQPAFIMDHV--ENVCNANECQQLVM 294
            |.:..||.||:|::.||:.|...|:.:.||||..|||.||....:.:.|  |::..|:|..:|:|
Frog   202 LEIEDEQVVFNSVLHWVKEDLDKRKDYFPELLRKVRLALLPSELLKEAVVCEDLIIADERSKLIM 266

  Fly   295 E---AFKWHLMPERRSRIATERTTPRKSTVGR-LLAVGGMD---------AHKGAISIESYCPRL 346
            :   ..|..:: :....:.:....|||:  |. ||.:||..         .||.    :...|:.
Frog   267 DEAVVCKKKIL-QNDGVVTSLCAKPRKA--GHTLLILGGQTFMCDKIYQVDHKA----KEIIPKA 324

  Fly   347 DKWTPWKHMTGRRLQFGAAVMEDKLILVGGR---DGLKTLNTVESLDLNTMAWAPLNAMATPRHG 408
            |..:|       |.:|.|..:..|:.:.|||   :|:.  ..|...|.....|:....|...|.|
Frog   325 DLPSP-------RKEFSACAIGCKVYVTGGRGSENGVS--KDVWVYDTINEEWSKSAPMLIARFG 380

  Fly   409 LGVAVLEGPLYAVGGHDGWS---------YLNTVERWDPIARTWSYVAPMSSMRSTAGVAVLGGR 464
            .|.|.||..||.||||...:         .|..||::||:...|:.:||:....|.|.|.....:
Frog   381 HGSAELENCLYVVGGHTAVAGVFPASPSVSLKQVEKYDPLTNKWTMMAPLRDGVSNAAVVSAKLK 445

  Fly   465 LYAVGGRDGSVCHR----SIECYDPHTNKWSLLAPMNRRRGGVGVTVANGFLYALGGHDCPASNP 525
            |:|.|   |:..||    .::||||..|:||:.|...:........|....::.:||.
Frog   446 LFAFG---GTSIHRDRVSKVQCYDPDENRWSIKAECPQPWRYTAAAVLGSQIFIMGGD------- 500

  Fly   526 MVCRTE----TVERYDPATDTWTLICSLALGRDAIGCALLGDRLIVVGGYDGNHALKSVEEYDPV 586
                ||    :..|:|..|:.||.|..:...|.:......|:::.|||||.|....|:::.|||.
Frog   501 ----TEFTAASAYRFDCETNQWTRIGDMTAKRMSCHALASGNKVYVVGGYFGTQRCKTLDCYDPT 561

  Fly   587 RNGWN-------ELAPMAF 598
            .:.||       .|.|.||
Frog   562 SDSWNSITSVPYSLIPTAF 580

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17754	NP_572549.2	BTB	70..170	CDD:279045	35/100 (35%)
		PHA03098	71..591	CDD:222983	166/555 (30%)
		BACK	179..281	CDD:285009	34/103 (33%)
		Kelch	323..369	CDD:128874	12/55 (22%)
		KELCH repeat	359..402	CDD:276965	11/45 (24%)
		Kelch	370..416	CDD:128874	14/48 (29%)
		KELCH repeat	406..449	CDD:276965	19/51 (37%)
		Kelch	418..463	CDD:128874	17/53 (32%)
		KELCH repeat	453..497	CDD:276965	17/47 (36%)
		Kelch	464..510	CDD:128874	15/49 (31%)
		Kelch_1	499..546	CDD:279660	10/50 (20%)
		KELCH repeat	500..549	CDD:276965	11/52 (21%)
		KELCH repeat	553..596	CDD:276965	15/49 (31%)
		Kelch	564..610	CDD:128874	16/42 (38%)
klhl25	NP_001072541.1	BTB_POZ	6..152	CDD:365784	50/144 (35%)
		PHA03098	37..566	CDD:222983	166/560 (30%)
		BACK	144..242	CDD:391941	36/97 (37%)
		Kelch 1	296..340		12/54 (22%)
		KELCH repeat	330..374	CDD:276965	11/45 (24%)
		Kelch 2	341..388		14/48 (29%)
		KELCH repeat	378..431	CDD:276965	20/52 (38%)
		Kelch 3	389..444		17/54 (31%)
		KELCH repeat	434..480	CDD:276965	17/48 (35%)
		Kelch 4	446..492		15/48 (31%)
		KELCH repeat	482..525	CDD:276965	11/53 (21%)
		Kelch 5	493..538		11/55 (20%)
		KELCH repeat	528..573	CDD:276965	14/44 (32%)
		Kelch 6	539..585		16/42 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D312716at33208
OrthoFinder	1	1.000	-	-		FOG0000036
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920