DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG17754 and Klhl24

DIOPT Version :10

Sequence 1:NP_572549.2 Gene:CG17754 / 31873 FlyBaseID:FBgn0030114 Length:654 Species:Drosophila melanogaster
Sequence 2:NP_083712.4 Gene:Klhl24 / 75785 MGIID:1923035 Length:600 Species:Mus musculus


Alignment Length:615 Identity:183/615 - (29%)
Similarity:290/615 - (47%) Gaps:89/615 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 VNQKESPSRDSTA-----------STSGHISMLADNTLESLSRDYSLGSLNSAGSQDEFFRCRDH 57
            :|:::...|||.|           |.:||...           |:|.||              .|
Mouse     9 LNREDLGVRDSPATKRKVFEMDPKSLTGHEYF-----------DFSSGS--------------SH 48

  Fly    58 ADNILKRMQLYVDSQQLCDVVLIAGIDGKRVPAHRLVLSASSAYFSAMFTGSLRETKEQEVTLGE 122
            |:|||:....:.||:...||::.  ::||..|.||.||||.|:||.|||....||::|..|.:..
Mouse    49 AENILQIFNEFRDSRLFTDVIIC--VEGKEFPCHRAVLSACSSYFRAMFCNDHRESREMLVEING 111

  Fly   123 VHGDALHLLVQYCYTGFIEMREDTVETLLATACLLQLNAVVTACCNFLARQLHPSNCLGFAFFAE 187
            :..:|:...:||.|||.:::..:.|:.|..|:.|.|::.:..||..||..||.|.||||...||:
Mouse   112 ILAEAMECFLQYVYTGKVKITTENVQYLFETSSLFQISVLRDACAKFLEEQLDPCNCLGIQRFAD 176

  Fly   188 QQSCTTLLRLAQAYTCQYFMQVCQNQEFFQLNADQLGKLLSSDDLNVPSEQDVFHSLMSWVRHDS 252
            ..|..||....:.:..|.|..|.|::||.:|:.|:|...:.||:|.:..|:.||.::|.||....
Mouse   177 THSLKTLFTKCKTFALQTFEDVSQHEEFLELDKDELIDYICSDELVIGKEEMVFEAVMRWVYRAV 241

  Fly   253 AAREQHIPELLALVRLPLLQPAFIMDHVE---NVCNANECQQLVMEAFKWHLMPERRSRIATERT 314
            ..|...:.|||..||||||.|.:.:..||   .:.|:.||.||:.||.::|::   .:.:.:.||
Mouse   242 DLRRPLLHELLTHVRLPLLHPNYFVQTVEVDQLIQNSPECYQLLHEARRYHIL---GNEMMSPRT 303

  Fly   315 TPRKST--------VGRLLAVGGMDAHKGAISIESYCPRLDKWTPWKHMTG-RRLQFGAAVMEDK 370
            .||:||        ||....|||.:..    ..|.|.|...:|.....:.. .:.::....:.:.
Mouse   304 RPRRSTGYSEVIVVVGGCERVGGFNLP----YTECYDPVTGEWKSLAKLPEFTKSEYAVCALRND 364

  Fly   371 LILVGGRDGLK-------TLNT-VESLDLNTMAWAPLNAMATPRHGLGVAVLEGPLYAVGGHDGW 427
            :::.|||...:       .||. :....||...|         ||.:  |||.|.:|.|||:||.
Mouse   365 ILVSGGRINSRDVWIYNSQLNIWIRVASLNKGRW---------RHKM--AVLLGKVYVVGGYDGQ 418

  Fly   428 SYLNTVERWDPIARTWSYVAPMSSMRSTAGVAVLGGRLYAV-GGRDGSVCHRSIECYDPHTNKWS 491
            :.|::||.:|..:..|:.|||:....|:..|....|:|:.: ||.|.:.|...::.|||.||.|.
Mouse   419 NRLSSVECYDSFSNRWTEVAPLKEAVSSPAVTSCIGKLFVIGGGPDDNTCSDKVQSYDPETNSWL 483

  Fly   492 LLAPMNRRRGGVGVTVANGFLYALGGHDCPASNPMVCRTETVERYDPATDTWTLICSLALGRDAI 556
            |.|.:...:..:.....|..:|..||           .|:.|..|||..|.|..:.:....::..
Mouse   484 LRAAIPIAKRCITAVSLNNLIYVAGG-----------LTKAVYCYDPVEDYWMHVQNTFSRQENC 537

  Fly   557 GCALLGDRLIVVGG-YDGNHALKSVEEYDP 585
            |.::...::.::|| .:...|..::..|||
Mouse   538 GMSVCNGKIYILGGRRENGEATDTILCYDP 567

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG17754NP_572549.2 PHA03098 71..591 CDD:222983 165/537 (31%)
KELCH repeat 359..402 CDD:276965 8/50 (16%)
KELCH repeat 406..449 CDD:276965 19/42 (45%)
KELCH repeat 453..497 CDD:276965 16/44 (36%)
KELCH repeat 500..549 CDD:276965 11/48 (23%)
KELCH repeat 553..596 CDD:276965 7/34 (21%)
Klhl24NP_083712.4 BTB_POZ_KLHL24_KRIP6 48..168 CDD:349562 46/121 (38%)
PHA03098 62..566 CDD:222983 162/534 (30%)
Kelch 1 314..363 9/52 (17%)
KELCH repeat 354..393 CDD:276965 5/38 (13%)
Kelch 2 365..407 13/52 (25%)
KELCH repeat 397..441 CDD:276965 21/54 (39%)
Kelch 3 408..454 16/45 (36%)
KELCH repeat 444..489 CDD:276965 16/44 (36%)
Kelch 4 456..502 13/45 (29%)
KELCH repeat 492..529 CDD:276965 11/47 (23%)
Kelch 5 504..544 11/50 (22%)
KELCH repeat 536..578 CDD:276965 7/32 (22%)
Kelch 545..591 CDD:128874 6/23 (26%)
Kelch 6 546..592 6/22 (27%)

Return to query results.
Submit another query.