Protein Alignment CG17754 and Klhl13

DIOPT Version :10

• Sequence 1: NP_572549.2
• Gene: CG17754 / 31873
• FlyBaseID: FBgn0030114
• Length: 654
• Species: Drosophila melanogaster
• Sequence 2: NP_001368820.1
• Gene: Klhl13 / 67455
• MGIID: 1914705
• Length: 660
• Species: Mus musculus
• Alignment Length: 605
• Identity: 179/605 - (29%)
• Similarity: 293/605 - (48%)
• Gaps: 47/605 - (7%)

  Fly    45 AGSQDEFFRCRDHADNILKRM-QLYVDSQQLCDVVLIAGIDGKRVPAHRLVLSASSAYFSAMFTG 108
            ||| ...|....|:..:|:.. ||.:|. .||||.|:.|......|.||::::::|.||.|||||
Mouse    68 AGS-TRIFTSNSHSSVVLQGFDQLRLDG-LLCDVTLMPGDTDDAYPVHRVMMASASDYFKAMFTG 130

  Fly   109 SLRETKEQEVTLGEVHGDA---LHLLVQYCYTGFIEMREDTVETLLATACLLQLNAVVTACCNFL 170
            .:   ||||:...::||.:   |..::.:.||..:.:..||::..|..|..||:..|:..|..||
Mouse   131 GM---KEQELMCIKLHGVSRVGLRKIIDFIYTAKLSLNMDTLQDTLEAASFLQILPVLDFCKVFL 192

  Fly   171 ARQLHPSNCLGFAFFAEQQSCTTLLRLAQAYTCQYFMQVCQNQEFFQLNADQLGKLLSSDDLNVP 235
            ...:...||:.....|.....|.:.:...::..:.|..:....||.:|..::|..:|||:.|...
Mouse   193 ISGVTLDNCVEVGRIANTYHLTEVDKYVNSFVLKNFAALLSTGEFLKLPFERLAFVLSSNSLKRC 257

  Fly   236 SEQDVFHSLMSWV-----RHDSAAREQHIPELLALVRLPLLQPAFIMDHVENV---CNANECQQL 292
            :|.|:|.:...|:     |.|.||:      |:..:|.||:.|..::::|:.|   ...|.|..|
Mouse   258 TELDLFKATCRWLRLEEPRMDVAAK------LMKNIRFPLMTPQELINYVQTVDFMRTDNTCVNL 316

  Fly   293 VMEAFKWHLMPERRSRIATERTTPRKSTVGRLLAVGGMDAHKGAIS--IESYCPRLDKWTPWKHM 355
            ::||..:.:||..:..:.::||..|..|. ||:.:||:...:..:|  :..|..:..:|.....|
Mouse   317 LLEASNYQMMPFMQPVMQSDRTAIRSDTT-RLVTLGGVLRQQLVVSKELRMYDEKTHEWKSLAPM 380

  Fly   356 TGRRLQFGAAVMEDKLILVGGRD-----GLKTLNTVESLDLNTMAWAPLNAMATPRHGLGVAVLE 415
            ...|.|.|.||:.:.|.:|||:.     |...::||...|.....|..:.::...|....::.|:
Mouse   381 DAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWIQVASLNEKRTFFHLSALK 445

  Fly   416 GPLYAVGGHDGWSYLNTVERWDPIARTWSYVAPMSSMRSTAGVAVLGGRLYAVGGRDGSVCHRSI 480
            |.||||||.:....|.|||.::|....|:|||.|:.........|.||.:|..||.......:.:
Mouse   446 GFLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMNEPHYGHAGTVYGGVMYISGGITHDTFQKEL 510

  Fly   481 ECYDPHTNKWSLLAPMNRRRGGVGVTVANGFLYALGGHDCPASNP----MVCRTETVERYDPATD 541
            .|:||.|:||:..|||...||...:......||.:||:....::.    :.|     |.|.|..|
Mouse   511 MCFDPDTDKWTQKAPMTTVRGLHCMCTVGDRLYVIGGNHFRGTSDYDDVLSC-----EYYSPILD 570

  Fly   542 TWTLICSLALGRDAIGCALLGDRLIVVGGYDGNH--ALKSVEEYDPVRNGWNEL--APMAFARAG 602
            .||.|.|:..|:..:|.|:..:::.|||||..|:  .::.|::|||.:|.|:::  .|.:.....
Mouse   571 QWTPIASMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPEKNEWHKVFDLPESLGGIR 635

  Fly   603 ACVVAIPNVIPPAAQQPPPS 622
            ||.:   .|.||....|.||
Mouse   636 ACTL---TVYPPEEATPSPS 652

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG17754	NP_572549.2	PHA03098	71..591	CDD:222983	160/543 (29%)
		KELCH repeat	359..402	CDD:276965	14/47 (30%)
		KELCH repeat	406..449	CDD:276965	18/42 (43%)
		KELCH repeat	453..497	CDD:276965	14/43 (33%)
		KELCH repeat	500..549	CDD:276965	14/52 (27%)
		KELCH repeat	553..596	CDD:276965	14/46 (30%)
Klhl13	NP_001368820.1	BTB_POZ_KLHL9_13	74..201	CDD:349548	42/130 (32%)
		PHA03098	97..640	CDD:222983	163/560 (29%)
		KELCH repeat	384..432	CDD:276965	14/47 (30%)
		KELCH repeat	436..480	CDD:276965	18/43 (42%)
		KELCH repeat	483..528	CDD:276965	15/44 (34%)
		KELCH repeat	530..579	CDD:276965	15/53 (28%)
		KELCH repeat	582..629	CDD:276965	14/46 (30%)