DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG17754 and KLHL25

DIOPT Version :9

Sequence 1:NP_572549.2 Gene:CG17754 / 31873 FlyBaseID:FBgn0030114 Length:654 Species:Drosophila melanogaster
Sequence 2:NP_071925.2 Gene:KLHL25 / 64410 HGNCID:25732 Length:589 Species:Homo sapiens


Alignment Length:634 Identity:191/634 - (30%)
Similarity:286/634 - (45%) Gaps:95/634 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly    22 ISMLADNTLESLSRDYSLGSLNSAGSQDEFFRCRDHADNILKRMQLYVDSQQLCDVVLIAGIDGK 86
            :|:....|.:|.|   |.||:|..     .|....|.|.:|..:..........||.|.||  .:
Human     1 MSVSVHETRKSRS---STGSMNVT-----LFHKASHPDCVLAHLNTLRKHCMFTDVTLWAG--DR 55

  Fly    87 RVPAHRLVLSASSAYFSAMFTGSLRETKEQEVTLGE-VHGDALHLLVQYCYTGFIEMREDTVETL 150
            ..|.||.||:|||.||.|||:..|||:::..|...: :|.:.|.||:.:.|:..|.:.|:..|:|
Human    56 AFPCHRAVLAASSRYFEAMFSHGLRESRDDTVNFQDNLHPEVLELLLDFAYSSRIAINEENAESL 120

  Fly   151 LATACLLQLNAVVTACCNFLARQLHPSNCLGFAFFAEQQSCTTLLRLAQAYTCQYFMQVCQNQEF 215
            |....:||.:.|..|...||.:.|.||||||....::...|..|...:......:|..|.|:::|
Human   121 LEAGDMLQFHDVRDAAAEFLEKNLFPSNCLGMMLLSDAHQCRRLYEFSWRMCLVHFETVRQSEDF 185

  Fly   216 FQLNADQLGKLLSSDDLNVPSEQDVFHSLMSWVRHDSAAREQHIPELLALVRLPLLQPAFIMDHV 280
            ..|:.|.|..|:|||:|....|:.||.:::.||:||...|:.|:||||..|||.||....:.:.|
Human   186 NSLSKDTLLDLISSDELETEDERVVFEAILQWVKHDLEPRKVHLPELLRSVRLALLPSDCLQEAV 250

  Fly   281 --ENVCNANECQQLVM-EAFKWHLMPERRSRIATER-TTPRKSTVGR-LLAVGGMD--------- 331
              |.:..|:|..:|:| ||.:......:...:.|.. ..|||:  |. ||.:||..         
Human   251 SSEALLMADERTKLIMDEALRCKTRILQNDGVVTSPCARPRKA--GHTLLILGGQTFMCDKIYQV 313

  Fly   332 AHKGAISIESYCPRLDKWTPWKHMTGRRLQFGAAVMEDKLILVGGR---DGLK----TLNTVESL 389
            .||.    :...|:.|..:|       |.:|.|:.:..|:.:.|||   :|:.    ..:||.. 
Human   314 DHKA----KEIIPKADLPSP-------RKEFSASAIGCKVYVTGGRGSENGVSKDVWVYDTVHE- 366

  Fly   390 DLNTMAWAPLNAMATPRHGLGVAVLEGPLYAVGGHDGWS---------YLNTVERWDPIARTWSY 445
                 .|:....|...|.|.|.|.||..||.||||...:         .|..||::||.|..|..
Human   367 -----EWSKAAPMLIARFGHGSAELENCLYVVGGHTSLAGVFPASPSVSLKQVEKYDPGANKWMM 426

  Fly   446 VAPMSSMRSTAGVAVLGGRLYAVGGRDGSVCHR----SIECYDPHTNKWSLLAPMNRRRGGVGVT 506
            |||:....|.|.|.....:|:..|   |:..||    .::||||..|:|::.|...:........
Human   427 VAPLRDGVSNAAVVSAKLKLFVFG---GTSIHRDMVSKVQCYDPSENRWTIKAECPQPWRYTAAA 488

  Fly   507 VANGFLYALGGHDCPASNPMVCRTE----TVERYDPATDTWTLICSLALGRDAIGCALLGDRLIV 567
            |....::.:||.           ||    :..|:|..|:.||.|..:...|.:......|::|.|
Human   489 VLGSQIFIMGGD-----------TEFTAASAYRFDCETNQWTRIGDMTAKRMSCHALASGNKLYV 542

  Fly   568 VGGYDGNHALKSVEEYDPVRNGWNELAPMAFARAGACVVAIP-NVIPPA 615
            ||||.|....|:::.|||..:.||            |:..:| ::||.|
Human   543 VGGYFGTQRCKTLDCYDPTSDTWN------------CITTVPYSLIPTA 579

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG17754NP_572549.2 BTB 70..170 CDD:279045 36/100 (36%)
PHA03098 71..591 CDD:222983 172/558 (31%)
BACK 179..281 CDD:285009 36/103 (35%)
Kelch 323..369 CDD:128874 12/55 (22%)
KELCH repeat 359..402 CDD:276965 11/49 (22%)
Kelch 370..416 CDD:128874 14/52 (27%)
KELCH repeat 406..449 CDD:276965 21/51 (41%)
Kelch 418..463 CDD:128874 19/53 (36%)
KELCH repeat 453..497 CDD:276965 15/47 (32%)
Kelch 464..510 CDD:128874 13/49 (27%)
Kelch_1 499..546 CDD:279660 10/50 (20%)
KELCH repeat 500..549 CDD:276965 11/52 (21%)
KELCH repeat 553..596 CDD:276965 15/42 (36%)
Kelch 564..610 CDD:128874 15/46 (33%)
KLHL25NP_071925.2 BTB_POZ_KLHL25 24..151 CDD:349563 46/128 (36%)
PHA03098 39..566 CDD:222983 172/561 (31%)
BACK_KLHL25_ENC2 144..242 CDD:350589 38/97 (39%)
Kelch 1 296..340 12/54 (22%)
KELCH repeat 330..374 CDD:276965 11/49 (22%)
Kelch 2 341..388 14/52 (27%)
KELCH repeat 378..431 CDD:276965 22/52 (42%)
Kelch 3 389..444 19/54 (35%)
KELCH repeat 434..480 CDD:276965 15/48 (31%)
Kelch 4 446..492 13/48 (27%)
KELCH repeat 482..524 CDD:276965 11/52 (21%)
Kelch 5 494..538 11/54 (20%)
Kelch 6 539..585 18/53 (34%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4441
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D312716at33208
OrthoFinder 1 1.000 - - FOG0000036
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X9
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
54.820

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