DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG17754 and KLHL12

DIOPT Version :9

Sequence 1:NP_572549.2 Gene:CG17754 / 31873 FlyBaseID:FBgn0030114 Length:654 Species:Drosophila melanogaster
Sequence 2:XP_011508137.1 Gene:KLHL12 / 59349 HGNCID:19360 Length:623 Species:Homo sapiens


Alignment Length:564 Identity:211/564 - (37%)
Similarity:308/564 - (54%) Gaps:27/564 - (4%)


- Green bases have known domain annotations that are detailed below.


  Fly    57 HADNILKRMQLYVDSQQLCDVVLIAGIDGKRVPAHRLVLSASSAYFSAMFTGSLRETKEQEVTLG 121
            ||.:||..|.....|..||||.|  .::.|..||||:||:|.|.||.||||..|.|..:..|.:.
Human    70 HAKSILNSMNSLRKSNTLCDVTL--RVEQKDFPAHRIVLAACSDYFCAMFTSELSEKGKPYVDIQ 132

  Fly   122 EVHGDALHLLVQYCYTGFIEMREDTVETLLATACLLQLNAVVTACCNFLARQLHPSNCLGFAFFA 186
            .:....:.:|:.:.||..:.:..:.|:.||..||||||..|..|||.||..||.||||||...||
Human   133 GLTASTMEILLDFVYTETVHVTVENVQELLPAACLLQLKGVKQACCEFLESQLDPSNCLGIRDFA 197

  Fly   187 EQQSCTTLLRLAQAYTCQYFMQVCQNQEFFQLNADQLGKLLSSDDLNVPSEQDVFHSLMSWVRHD 251
            |..:|..|::.|:.::.::|.:|.|::||..|:..::.||:..|::.|.||:.||.::::||:|.
Human   198 ETHNCVDLMQAAEVFSQKHFPEVVQHEEFILLSQGEVEKLIKCDEIQVDSEEPVFEAVINWVKHA 262

  Fly   252 SAAREQHIPELLALVRLPLLQPAFIMDHVENV----CNANECQQLVMEAFKWHLMPERRSRIATE 312
            ...||:.:|.||..||:|||.|.:|.|.::..    |:. :|:.||.||.|:||.||.||::...
Human   263 KKEREESLPNLLQYVRMPLLTPRYITDVIDAEPFIRCSL-QCRDLVDEAKKFHLRPELRSQMQGP 326

  Fly   313 RTTPRKSTVGRLLAVGGMDAHKGAIS-IESYCPRLDKWTPWKHMTGRRLQFGAAVMEDKLILVGG 376
            ||..|......||.|||..:.:..|. :|.|.|:..:|:....:|.:|....:..:.|::.::||
Human   327 RTRARLGANEVLLVVGGFGSQQSPIDVVEKYDPKTQEWSFLPSITRKRRYVASVSLHDRIYVIGG 391

  Fly   377 RDGLKTLNTVESLDLNT---MAW---APLNAMATPRHGL-GVAVLEGPLYAVGGHDGWSYLNTVE 434
            .||...|::||.||...   ..|   ||:|.    |.|| |...|...:|..||.||.....::|
Human   392 YDGRSRLSSVECLDYTADEDGVWYSVAPMNV----RRGLAGATTLGDMIYVSGGFDGSRRHTSME 452

  Fly   435 RWDPIARTWSYVAPMSSMRSTAGVAVLGGRLYAVGGRDGSVCHRSIECYDPHTNKWSLLAPMNRR 499
            |:||....||.:..|.:.|..||:.|..|.:|.:||.||.....|:|.|||||..|:.:.||..:
Human   453 RYDPNIDQWSMLGDMQTAREGAGLVVASGVIYCLGGYDGLNILNSVEKYDPHTGHWTNVTPMATK 517

  Fly   500 RGGVGVTVANGFLYALGGHDCPASNPMVCRTETVERYDPATDTWTLICSLALGRDAIGCALLGDR 564
            |.|.||.:.|..:|.:||.|..|      ...:||.|:..||:||.:.|:...|..:|..:|..|
Human   518 RSGAGVALLNDHIYVVGGFDGTA------HLSSVEAYNIRTDSWTTVTSMTTPRCYVGATVLRGR 576

  Fly   565 LIVVGGYDGNHALKSVEEYDPVRNGWNELAPMAFAR--AGACVV 606
            |..:.|||||..|.|:|.|||:.:.|..:..|...|  ||.||:
Human   577 LYAIAGYDGNSLLSSIECYDPIIDSWEVVTSMGTQRCDAGVCVL 620

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG17754NP_572549.2 BTB 70..170 CDD:279045 40/99 (40%)
PHA03098 71..591 CDD:222983 199/531 (37%)
BACK 179..281 CDD:285009 39/101 (39%)
Kelch 323..369 CDD:128874 12/46 (26%)
KELCH repeat 359..402 CDD:276965 15/48 (31%)
Kelch 370..416 CDD:128874 18/52 (35%)
KELCH repeat 406..449 CDD:276965 16/43 (37%)
Kelch 418..463 CDD:128874 16/44 (36%)
KELCH repeat 453..497 CDD:276965 19/43 (44%)
Kelch 464..510 CDD:128874 19/45 (42%)
Kelch_1 499..546 CDD:279660 17/46 (37%)
KELCH repeat 500..549 CDD:276965 17/48 (35%)
KELCH repeat 553..596 CDD:276965 17/42 (40%)
Kelch 564..610 CDD:128874 20/45 (44%)
KLHL12XP_011508137.1 BTB 78..181 CDD:279045 41/104 (39%)
PHA03098 101..556 CDD:222983 172/465 (37%)
BACK 190..291 CDD:285009 39/100 (39%)
KELCH repeat 329..370 CDD:276965 11/40 (28%)
Kelch 337..384 CDD:128874 12/46 (26%)
KELCH repeat 374..420 CDD:276965 13/45 (29%)
Kelch 385..434 CDD:128874 18/52 (35%)
KELCH repeat 424..467 CDD:276965 15/42 (36%)
Kelch 436..481 CDD:128874 16/44 (36%)
KELCH repeat 471..514 CDD:276965 18/42 (43%)
Kelch 482..528 CDD:128874 19/45 (42%)
KELCH repeat 518..562 CDD:276965 18/49 (37%)
Kelch 529..575 CDD:128874 16/51 (31%)
KELCH repeat 565..610 CDD:276965 18/44 (41%)
Kelch 576..620 CDD:128874 19/43 (44%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4441
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D312716at33208
OrthoFinder 1 1.000 - - FOG0000036
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X9
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
54.820

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