Protein Alignment CG17754 and KLHL26

DIOPT Version :10

• Sequence 1: NP_572549.2
• Gene: CG17754 / 31873
• FlyBaseID: FBgn0030114
• Length: 654
• Species: Drosophila melanogaster
• Sequence 2: NP_001332910.1
• Gene: KLHL26 / 55295
• HGNCID: 25623
• Length: 644
• Species: Homo sapiens
• Alignment Length: 639
• Identity: 179/639 - (28%)
• Similarity: 290/639 - (45%)
• Gaps: 91/639 - (14%)

  Fly    43 NSAGSQDEFFRCR----DHADNILKRMQLYVDSQQLCDVVLIAGIDGKRVPAHRLVLSASSAY-- 101
            ||...::...:|.    .|:.::|:.:.......||.||||.  |:.:..|||::||:|.|.|
Human    27 NSTADKNGALKCTFSAPSHSTSLLQGLATLRAQGQLLDVVLT--INREAFPAHKVVLAACSDYFR 89

  Fly   102 ---------------------------FSAMFTGSLRETKEQEVTLGEVHGDALHLLVQYCYTGF 139
                                       |.|||||.:||..:..:.|..|....|..::.:.|:..
Human    90 LLFPRPDHSWLAKTPLSHCQPHVVFLPFRAMFTGGMREASQDVIELKGVSARGLRHIIDFAYSAE 154

  Fly   140 IEMREDTVETLLATACLLQLNAVVTACCNFLARQLHPSNCLGFAFFAEQQSCTTLLRLAQAYTCQ 204
            :.:..|.|:.:|..|..||:..||..|..||...:....||.....|...|..:|.....|:|.:
Human   155 VTLDLDCVQDVLGAAVFLQMLPVVELCEEFLKAAMSVETCLNIGQMATTFSLASLRESVDAFTFR 219

  Fly   205 YFMQVCQNQEFFQLNADQLGKLLSSDDLNVPSEQDVFHSLMSWVRHDSAAREQ--HIPELLALVR 267
            :|:|:.:.::|.:|..::|...|.|:.|...:|.|:|.:.:.|::||.|.|.:  |:   |..:|
Human   220 HFLQIAEEEDFLRLPLERLVFFLQSNRLQSCAEIDLFRAAVRWLQHDPARRPRASHV---LCHIR 281

  Fly   268 LPLLQPAFIMDHVENVCNANE---CQQLVMEAFKWHLMPERRSRIATERTTPRKSTVGRLLAVGG 329
            .||:|.:.::|.|:.:....|   |:|.::|||.:.::|.|:..:.:.||..| |.|..|:..||
Human   282 FPLMQSSELVDSVQTLDIMVEDVLCRQYLLEAFNYQVLPFRQHEMQSPRTAVR-SDVPSLVTFGG 345

  Fly   330 MDAHKGAISIESYCPRLDKWTP----WKHMTGRRLQFG-----AAVMEDKLILVGG-----RDGL 380
            ........|:.|...:|.:  |    ::.:|  .::.|     .||:::.:.:.||     |.|.
Human   346 TPYTDSDRSVSSKVYQLPE--PGARHFRELT--EMEVGCSHTCVAVLDNFVYVAGGQHLQYRSGE 406

  Fly   381 KTLNTVESLDLNTMAWAPLNAMATPRHGLGVAVLEGPLYAVGGHDGWSYLNTVERWDPIARTWSY 445
            ..::.....|.:...|..|.||...|....:.||.|.:||.||.:....|.:|||:.|....|.|
Human   407 GAVDACYRYDPHLNRWLRLQAMQESRIQFQLNVLCGMVYATGGRNRAGSLASVERYCPRRNEWGY 471

  Fly   446 VAPMSSMRSTAG--VAVLGGRLYAVGGRDGSV-CHRSIECYDPHTNKWSLLAPMNRRRGGVGVTV 507
            ..  |..|.|.|  .|..|||||..||...|| ..:::.||||..::|...|||:..|....:..
Human   472 AC--SLKRRTWGHAGAASGGRLYISGGYGISVEDKKALHCYDPVADQWEFKAPMSEPRVLHAMVG 534

  Fly   508 ANGFLYALGGHDCPASNPMVCRTETVER---------YDPATDTWTLICSLALGRDAIGCALLGD 563
            |.|.:|||||           |.:.|:|         |.|.||.||.:..:..|:...||.||..
Human   535 AGGRIYALGG-----------RMDHVDRCFDVLAVEYYVPETDQWTSVSPMRAGQSEAGCCLLER 588

  Fly   564 RLIVVGGYDG--NHALKSVEEYDPVRNGWNELAPMAFARAGACVVAIPNVIPPA 615
            ::.:||||:.  |:....|:.|:...:.|..  .:.|..:.|.:...|.::|.|
Human   589 KIYIVGGYNWRLNNVTGIVQVYNTDTDEWER--DLHFPESFAGIACAPVLLPRA 640

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG17754	NP_572549.2	PHA03098	71..591	CDD:222983	168/581 (29%)
		KELCH repeat	359..402	CDD:276965	10/52 (19%)
		KELCH repeat	406..449	CDD:276965	15/42 (36%)
		KELCH repeat	453..497	CDD:276965	20/46 (43%)
		KELCH repeat	500..549	CDD:276965	17/57 (30%)
		KELCH repeat	553..596	CDD:276965	12/44 (27%)
KLHL26	NP_001332910.1	BTB_POZ_KLHL26	45..194	CDD:349564	40/150 (27%)
		BACK_KLHL26	189..285	CDD:350540	27/98 (28%)
		NanM	369..618	CDD:442289	79/263 (30%)
		KELCH repeat	381..428	CDD:276965	9/46 (20%)
		KELCH repeat	432..476	CDD:276965	16/45 (36%)
		KELCH repeat	479..525	CDD:276965	20/45 (44%)
		KELCH repeat	527..574	CDD:276965	17/57 (30%)
		KELCH repeat	578..619	CDD:276965	12/40 (30%)