DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17754 and Keap1

DIOPT Version :9

Sequence 1:	NP_572549.2	Gene:	CG17754 / 31873	FlyBaseID:	FBgn0030114	Length:	654	Species:	Drosophila melanogaster
Sequence 2:	NP_001103775.1	Gene:	Keap1 / 50868	MGIID:	1858732	Length:	624	Species:	Mus musculus

Alignment Length:	586	Identity:	206/586 - (35%)
Similarity:	311/586 - (53%)	Gaps:	30/586 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 GSQDEFFRCRDH---ADNILKRMQLYVDSQQLCDVVL---IAGIDGKRVPAHRLVLSASSAYFSA 104
            |::...:...||   |..::..::|   |||||||.|   ...|...:..||::||::||..|.|
Mouse    48 GNRTFSYTLEDHTKQAFGVMNELRL---SQQLCDVTLQVKYEDIPAAQFMAHKVVLASSSPVFKA 109

  Fly   105 MFTGSLRETKEQEVTLGEVHGDALHLLVQYCYTGFIEMREDTVETLLATACLLQLNAVVTACCNF 169
            |||..|||...:.|::..:|...:..|:::.||..|.:.|..|..::..|.:.|:::||.||.:|
Mouse   110 MFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTASISVGEKCVLHVMNGAVMYQIDSVVRACSDF 174

  Fly   170 LARQLHPSNCLGFAFFAEQQSCTTLLRLAQAYTCQYFMQVCQNQEFFQLNADQLGKLLSSDDLNV 234
            |.:||.|||.:|.|.||||..||.|.:.|:.|...:|.:|.:.:|||.|:..||..|:|.|||||
Mouse   175 LVQQLDPSNAIGIANFAEQIGCTELHQRAREYIYMHFGEVAKQEEFFNLSHCQLATLISRDDLNV 239

  Fly   235 PSEQDVFHSLMSWVRHDSAAREQHIPELLALVRLPLLQPAFIMDHVE--NVCNAN-ECQQLVMEA 296
            ..|.:|||:.:.||::|...|..::..||..||...|.|.|:...::  .:..|: .|:..:::.
Mouse   240 RCESEVFHACIDWVKYDCPQRRFYVQALLRAVRCHALTPRFLQTQLQKCEILQADARCKDYLVQI 304

  Fly   297 FKWHLMPERRSRIATERTTPRKSTVGRLLAVGGMDAHKGAISIESYCPRLDKWTPWKHMTGRRLQ 361
            |:     |......|:....|...||||:...|....:....:|:|.|....|.....:...|..
Mouse   305 FQ-----ELTLHKPTQAVPCRAPKVGRLIYTAGGYFRQSLSYLEAYNPSNGSWLRLADLQVPRSG 364

  Fly   362 FGAAVMEDKLILVGGR----DGLKTLNTVESLDLNTMAWAPLNAMATPRHGLGVAVLEGPLYAVG 422
            ....|:...|..||||    ||....:.::..:..|..|:|..:|:.||:.:||.|::|.:||||
Mouse   365 LAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCASMSVPRNRIGVGVIDGHIYAVG 429

  Fly   423 GHDGWSYLNTVERWDPIARTWSYVAPMSSMRSTAGVAVLGGRLYAVGGRDGSVCHRSIECYDPHT 487
            |..|..:.::|||::|....|..||||.:.|...|||||...||||||.||:....|.|||.|..
Mouse   430 GSHGCIHHSSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPER 494

  Fly   488 NKWSLLAPMNRRRGGVGVTVANGFLYALGGHDCPASNPMVCRTETVERYDPATDTWTLICSLALG 552
            |:|.::.|||..|.|.||.|.:..:||.||:|...      :..:|||||..|:|||.:..:...
Mouse   495 NEWRMITPMNTIRSGAGVCVLHNCIYAAGGYDGQD------QLNSVERYDVETETWTFVAPMRHH 553

  Fly   553 RDAIGCALLGDRLIVVGGYDGNHALKSVEEYDPVRNGWNELAPMAFARAGACVVAIPNVIPPAAQ 617
            |.|:|..:...::.|:|||||:..|.|||.|||..:.|:|:..|...|:|   |.:...:.|..:
Mouse   554 RSALGITVHQGKIYVLGGYDGHTFLDSVECYDPDSDTWSEVTRMTSGRSG---VGVAVTMEPCRK 615

  Fly   618 Q 618
            |
Mouse   616 Q 616

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17754	NP_572549.2	BTB	70..170	CDD:279045	37/102 (36%)
		PHA03098	71..591	CDD:222983	193/529 (36%)
		BACK	179..281	CDD:285009	41/101 (41%)
		Kelch	323..369	CDD:128874	9/45 (20%)
		KELCH repeat	359..402	CDD:276965	12/46 (26%)
		Kelch	370..416	CDD:128874	16/49 (33%)
		KELCH repeat	406..449	CDD:276965	18/42 (43%)
		Kelch	418..463	CDD:128874	21/44 (48%)
		KELCH repeat	453..497	CDD:276965	22/43 (51%)
		Kelch	464..510	CDD:128874	23/45 (51%)
		Kelch_1	499..546	CDD:279660	19/46 (41%)
		KELCH repeat	500..549	CDD:276965	19/48 (40%)
		KELCH repeat	553..596	CDD:276965	18/42 (43%)
		Kelch	564..610	CDD:128874	19/45 (42%)
Keap1	NP_001103775.1	BTB	67..176	CDD:279045	39/111 (35%)
		PHA03098	95..596	CDD:222983	186/511 (36%)
		BACK	184..286	CDD:285009	41/101 (41%)
		Kelch	327..372	CDD:128874	8/44 (18%)
		Kelch 1	327..372		8/44 (18%)
		KELCH repeat	362..409	CDD:276965	12/46 (26%)
		Kelch	373..423	CDD:128874	16/49 (33%)
		Kelch 2	373..423		16/49 (33%)
		KELCH repeat	413..456	CDD:276965	18/42 (43%)
		Kelch 3	424..470		21/45 (47%)
		Kelch	424..469	CDD:128874	20/44 (45%)
		KELCH repeat	460..503	CDD:276965	21/42 (50%)
		Kelch	471..517	CDD:128874	23/45 (51%)
		Kelch 4	471..517		23/45 (51%)
		KELCH repeat	507..551	CDD:276965	19/49 (39%)
		Kelch	518..564	CDD:128874	17/51 (33%)
		Kelch 5	519..564		17/50 (34%)
		KELCH repeat	554..597	CDD:276965	18/42 (43%)
		Kelch	565..611	CDD:128874	19/48 (40%)
		Kelch 6	565..611		19/48 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4441
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D312716at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820