DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG17754 and KLHL17

DIOPT Version :9

Sequence 1:	NP_572549.2	Gene:	CG17754 / 31873	FlyBaseID:	FBgn0030114	Length:	654	Species:	Drosophila melanogaster
Sequence 2:	XP_006710663.1	Gene:	KLHL17 / 339451	HGNCID:	24023	Length:	665	Species:	Homo sapiens

Alignment Length:	652	Identity:	249/652 - (38%)
Similarity:	347/652 - (53%)	Gaps:	63/652 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 QKESPSRDSTASTSGHISMLADNTLESLSRD-YSLGSLNSAGSQDEFFRCRDHADNILKRMQLYV 69
            |..:|..:.|.......:...:..::.|||: :|:...:.....|.|.        .:.||:
Human    33 QPPAPEAERTRPRQARPAAPMEGAVQLLSREGHSVAHNSKRHYHDAFV--------AMSRMR--- 86

  Fly    70 DSQQLCDVVLIAGIDGKRVPAHRLVLSASSAYFSAMFTGSLRETKEQEVTLGEVHGDALHLLVQY 134
            ....|||:||  .:..|.:.||::||::.|.||.||||..:.|:::..|||.::...||..|||:
Human    87 QRGLLCDIVL--HVAAKEIRAHKVVLASCSPYFHAMFTNEMSESRQTHVTLHDIDPQALDQLVQF 149

  Fly   135 CYTGFIEMREDTVETLLATACLLQLNAVVTACCNFLARQLHPSNCLGFAFFAEQQSCTTLLRLAQ 199
            .||..|.:.|..|:|||..|.|||||.|..|||.||..||.||||||...||:..||:.||:.|.
Human   150 AYTAEIVVGEGNVQTLLPAASLLQLNGVRDACCKFLLSQLDPSNCLGIRGFADAHSCSDLLKAAH 214

  Fly   200 AYTCQYFMQVCQNQEFFQLNADQLG-----------------------KLLSSDDLNVPSEQDVF 241
            .|..|:|:.|.:.:||..|...|..                       :|:|||.||||||::|:
Human   215 RYVLQHFVDVAKTEEFMLLPLKQASSGLPGSTGPSPDLRSEDPHSQVLELVSSDSLNVPSEEEVY 279

  Fly   242 HSLMSWVRHDSAAREQHIPELLALVRLPLLQPAFIMDHVEN---VCNANECQQLVMEAFKWHLMP 303
            .:::|||:||..||.||:|.|:..||||||...|::.||:.   |.:..:|:.|::||.|:||:|
Human   280 RAVLSWVKHDVDARRQHVPRLMKCVRLPLLSRDFLLGHVDAESLVRHHPDCKDLLIEALKFHLLP 344

  Fly   304 ERRSRIATERTTPRK-STVGRLL-AVGGMDAHKGAI-----SIESYCPRLDKWTPWKHMTGRRLQ 361
            |:|..:.|.||.||: ...|.:| ||||     |::     ..|:|..|.|:|.....|:.||.:
Human   345 EQRGVLGTSRTRPRRCEGAGPVLFAVGG-----GSLFAIHGDCEAYDTRTDRWHVVASMSTRRAR 404

  Fly   362 FGAAVMEDKLILVGGRDGLKTLNTVESLDLNTMAWAPLNAMATPRHGLGVAVLEGPLYAVGGHDG 426
            .|.|.:.::|..|||.||...|.||||.|..|..|.|..:|.|.|..||||.|.|.||:.||:||
Human   405 VGVAAVGNRLYAVGGYDGTSDLATVESYDPVTNTWQPEVSMGTRRSCLGVAALHGLLYSAGGYDG 469

  Fly   427 WSYLNTVERWDPIARTWSYVAPMSSMRSTAGVAVLGGRLYAVGGRDGSVCHRSIECYDPHTNKWS 491
            .|.||:.||:||:..||:.||.||:.|....||.|.|.||||||.|.|....::|.|:|..|.||
Human   470 ASCLNSAERYDPLTGTWTSVAAMSTRRRYVRVATLDGNLYAVGGYDSSSHLATVEKYEPQVNVWS 534

  Fly   492 LLAPMNRRRGGVGVTVANGFLYALGGHDCPASNPMVCRTETVERYDPATDTWTLICSLALGRDAI 556
            .:|.|..||...||.|..|.||..||:|..:     | ..:||||.|....|..:..:.:.|...
Human   535 PVASMLSRRSSAGVAVLEGALYVAGGNDGTS-----C-LNSVERYSPKAGAWESVAPMNIRRSTH 593

  Fly   557 GCALLGDRLIVVGGYDGNHALKSVEEYDPVRNGWNELAPMAFARAGACVVAIPNVIPPAAQQPPP 621
            ....:...|..|||.||:.:|.|:|:|:|..|.| ..|...|.|..:..||:..::    ..|||
Human   594 DLVAMDGWLYAVGGNDGSSSLNSIEKYNPRTNKW-VAASCMFTRRSSVGVAVLELL----NFPPP 653

  Fly   622 SA 623
            |:
Human   654 SS 655

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17754	NP_572549.2	BTB	70..170	CDD:279045	44/99 (44%)
		PHA03098	71..591	CDD:222983	228/552 (41%)
		BACK	179..281	CDD:285009	48/124 (39%)
		Kelch	323..369	CDD:128874	16/51 (31%)
		KELCH repeat	359..402	CDD:276965	18/42 (43%)
		Kelch	370..416	CDD:128874	23/45 (51%)
		KELCH repeat	406..449	CDD:276965	24/42 (57%)
		Kelch	418..463	CDD:128874	23/44 (52%)
		KELCH repeat	453..497	CDD:276965	20/43 (47%)
		Kelch	464..510	CDD:128874	21/45 (47%)
		Kelch_1	499..546	CDD:279660	18/46 (39%)
		KELCH repeat	500..549	CDD:276965	17/48 (35%)
		KELCH repeat	553..596	CDD:276965	15/42 (36%)
		Kelch	564..610	CDD:128874	18/45 (40%)
KLHL17	XP_006710663.1	BTB	82..186	CDD:279045	47/108 (44%)
		PHA03098	92..581	CDD:222983	213/501 (43%)
		BACK	194..318	CDD:285009	47/123 (38%)
		Kelch	366..412	CDD:128874	16/50 (32%)
		Kelch_1	401..446	CDD:279660	19/44 (43%)
		KELCH repeat	402..445	CDD:276965	18/42 (43%)
		KELCH repeat	449..492	CDD:276965	24/42 (57%)
		Kelch	460..506	CDD:128874	23/45 (51%)
		KELCH repeat	496..540	CDD:276965	20/43 (47%)
		Kelch	508..553	CDD:128874	21/44 (48%)
		KELCH repeat	543..587	CDD:276965	17/49 (35%)
		Kelch	555..600	CDD:128874	13/50 (26%)
		KELCH repeat	590..635	CDD:276965	15/45 (33%)
		Kelch	602..646	CDD:128874	18/44 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4441
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D312716at33208
OrthoFinder	1	1.000	-	-		FOG0000036
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.820