DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17754 and klhl17

DIOPT Version :9

Sequence 1:	NP_572549.2	Gene:	CG17754 / 31873	FlyBaseID:	FBgn0030114	Length:	654	Species:	Drosophila melanogaster
Sequence 2:	XP_003201248.1	Gene:	klhl17 / 336187	ZFINID:	ZDB-GENE-030131-8131	Length:	591	Species:	Danio rerio

Alignment Length:	613	Identity:	255/613 - (41%)
Similarity:	352/613 - (57%)	Gaps:	46/613 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 LADNTLESLSRDYSLGSLNSAGSQDEFFRCRDHADNI--LKRMQLYVDSQQLCDVVLIAGIDGKR 87
            :.:..::.|:||....|.||.         |.:.|:.  :.||:   ....|||:||  .:..|.
Zfish     1 MMEGGMQLLNRDGHSISHNSK---------RHYHDSFVSMNRMR---QRGLLCDIVL--HVANKE 51

  Fly    88 VPAHRLVLSASSAYFSAMFTGSLRETKEQEVTLGEVHGDALHLLVQYCYTGFIEMREDTVETLLA 152
            :.||::||::.|.||.||||..:.|:::..|||.::...||..||||.||..|.:.|..|:|||.
Zfish    52 IKAHKVVLASCSPYFHAMFTNEMSESRQTHVTLHDIDPQALEQLVQYAYTAEIVVGEGNVQTLLP 116

  Fly   153 TACLLQLNAVVTACCNFLARQLHPSNCLGFAFFAEQQSCTTLLRLAQAYTCQYFMQVCQNQEFFQ 217
            .|.|||||.|..|||.||..||.||||||...||:..||:.||:.|..|..|:|::|.:.:||..
Zfish   117 AASLLQLNGVRDACCKFLLSQLDPSNCLGIRGFADTHSCSDLLKSAHKYVLQHFVEVSKTEEFML 181

  Fly   218 LNADQLGKLLSSDDLNVPSEQDVFHSLMSWVRHDSAAREQHIPELLALVRLPLLQPAFIMDHVEN 282
            |...|:..|:|||:||||||::|:.:::|||:||...|.||:|.|:..||||||...|:|.:|:.
Zfish   182 LPLKQVLDLISSDNLNVPSEEEVYRAVLSWVKHDIDGRRQHVPRLMKCVRLPLLTRDFLMSNVDT 246

  Fly   283 ---VCNANECQQLVMEAFKWHLMPERRSRIATERTTPRK----STVGRLLAVGGMDAHKGAI--- 337
               |.:.:||:.|::||.|:|||||:|..::..||.||:    |.|  |.||||     |::
Zfish   247 ELLVRHHSECKDLLIEALKYHLMPEQRGVLSNSRTRPRRCEGASPV--LFAVGG-----GSLFAI 304

  Fly   338 --SIESYCPRLDKWTPWKHMTGRRLQFGAAVMEDKLILVGGRDGLKTLNTVESLDLNTMAWAPLN 400
              ..|:|..|.|:|.....|:.||.:.|.|.:.:||..|||.||...|.||||.|..|.||.|..
Zfish   305 HGDCEAYDTRTDRWHMVASMSTRRARVGVAAIGNKLYAVGGYDGTSDLATVESYDPVTNAWQPEV 369

  Fly   401 AMATPRHGLGVAVLEGPLYAVGGHDGWSYLNTVERWDPIARTWSYVAPMSSMRSTAGVAVLGGRL 465
            :|.|.|..||||||.|.|||.||:||.|.||:.||:||:..||:.:|.||:.|....||.|.|.|
Zfish   370 SMGTRRSCLGVAVLHGLLYAAGGYDGASCLNSAERYDPLTSTWTSIAAMSTRRRYVRVATLDGSL 434

  Fly   466 YAVGGRDGSVCHRSIECYDPHTNKWSLLAPMNRRRGGVGVTVANGFLYALGGHDCPASNPMVCRT 530
            |||||.|.|....::|.|||.:|.|:.:|.|..||...||.|..|.||..||:|..:     | .
Zfish   435 YAVGGYDSSSHLATVEKYDPQSNAWTAIANMLSRRSSAGVAVLEGMLYVAGGNDGTS-----C-L 493

  Fly   531 ETVERYDPATDTWTLICSLALGRDAIGCALLGDRLIVVGGYDGNHALKSVEEYDPVRNGWNELAP 595
            .:||||:|.|:||..:..:.:.|.......:...|..|||.||:.:|.|:|:|:|..|.| ..|.
Zfish   494 NSVERYNPKTNTWEGVAPMNIRRSTHDLVAMDGWLYAVGGNDGSSSLNSIEKYNPRSNKW-VAAS 557

  Fly   596 MAFARAGACVVAIPNVIPPAAQQPPPSA 623
            ..|.|..:..||:..::    ..||||:
Zfish   558 CMFTRRSSVGVAVLELL----NFPPPSS 581

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17754	NP_572549.2	BTB	70..170	CDD:279045	45/99 (45%)
		PHA03098	71..591	CDD:222983	235/531 (44%)
		BACK	179..281	CDD:285009	47/101 (47%)
		Kelch	323..369	CDD:128874	16/50 (32%)
		KELCH repeat	359..402	CDD:276965	20/42 (48%)
		Kelch	370..416	CDD:128874	26/45 (58%)
		KELCH repeat	406..449	CDD:276965	25/42 (60%)
		Kelch	418..463	CDD:128874	23/44 (52%)
		KELCH repeat	453..497	CDD:276965	20/43 (47%)
		Kelch	464..510	CDD:128874	21/45 (47%)
		Kelch_1	499..546	CDD:279660	20/46 (43%)
		KELCH repeat	500..549	CDD:276965	19/48 (40%)
		KELCH repeat	553..596	CDD:276965	15/42 (36%)
		Kelch	564..610	CDD:128874	18/45 (40%)
klhl17	XP_003201248.1	PHA03098	41..507	CDD:222983	220/480 (46%)
		KELCH repeat	328..371	CDD:276965	20/42 (48%)
		KELCH repeat	375..418	CDD:276965	25/42 (60%)
		KELCH repeat	422..466	CDD:276965	20/43 (47%)
		KELCH repeat	469..513	CDD:276965	19/49 (39%)
		KELCH repeat	516..561	CDD:276965	15/45 (33%)
		Kelch	528..572	CDD:128874	18/44 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4441
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D312716at33208
OrthoFinder	1	1.000	-	-		FOG0000036
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.820