DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG17754 and enc3

DIOPT Version :9

Sequence 1:	NP_572549.2	Gene:	CG17754 / 31873	FlyBaseID:	FBgn0030114	Length:	654	Species:	Drosophila melanogaster
Sequence 2:	NP_001001402.2	Gene:	enc3 / 327531	ZFINID:	ZDB-GENE-030131-5742	Length:	589	Species:	Danio rerio

Alignment Length:	613	Identity:	174/613 - (28%)
Similarity:	286/613 - (46%)	Gaps:	57/613 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 SLSRDYSLGSLNSAGSQD-EFFRCRDHADNILKRMQLYVDSQQLCDVVLIAGIDGKRV-PAHRLV 94
            |:|...:..|.:|:||.: :.|....|||::|..:.|....:...||||.|   |.|| |.||.|
Zfish     2 SVSNHENRKSRSSSGSMNIQLFHKTSHADSLLTHLNLLRKRRVFTDVVLRA---GHRVFPCHRAV 63

  Fly    95 LSASSAYFSAMFTGSLRETKEQEVTLGE-VHGDALHLLVQYCYTGFIEMREDTVETLLATACLLQ 158
            |::.|.||.|||:|.|:|:::.||...: :|.:.|.||:.|.|:..:.:.|:..|:||....:||
Zfish    64 LASCSRYFEAMFSGGLKESRDAEVNFHDSLHPEVLELLLDYAYSARVIINEENAESLLEAGDMLQ 128

  Fly   159 LNAVVTACCNFLARQLHPSNCLGFAFFAEQQSCTTLLRLAQAYTCQYFMQVCQNQEFFQLNADQL 223
            .:.:..|...||.:.||||||||....::...|..|..|:.......|..:...::|..|..|::
Zfish   129 FHDIRDAASEFLEKNLHPSNCLGMMLLSDAHQCQRLYELSWRMCLANFANLYHTEDFLSLPKDKV 193

  Fly   224 GKLLSSDDLNVPSEQDVFHSLMSWVRHDSAAREQHIPELLALVRLPLLQPAFIMDHV---ENVCN 285
            .:|:.|::|.|..|..|:.:::.|||.|...|...:|:||..|||.||...:::.:|   |.|..
Zfish   194 QELVFSEELEVEDESIVYEAVIDWVRADIGRRHLDLPDLLRCVRLALLPETYLLKNVASEELVMG 258

  Fly   286 ANECQQLVMEAFKWHLMPERRSRIATE-RTTPRKSTVGRLLAVGG---------MDAHKGAISIE 340
            ....:::|.:|.:..:...:...:.|. ...|||.:.. ||.:||         |..||.    :
Zfish   259 HKVGREIVEDAVRCKMKILQNDGVVTGFCARPRKVSQA-LLLLGGQTFMCDKVYMIDHKA----K 318

  Fly   341 SYCPRLDKWTPWKHMTGRRLQFGAAVMEDKLILVGGRDGLKTLNTVESLDLNTM--AWAPLNAMA 403
            ...|:.|..:|       |.:..|..:..|:.:.||| |.:...:.:....:|:  .|:....|.
Zfish   319 EITPKTDLPSP-------RKECSACAIGCKVYVTGGR-GSENGASKDVWVYDTLHDEWSKAAQML 375

  Fly   404 TPRHGLGVAVLEGPLYAVGGHDGWS---------YLNTVERWDPIARTWSYVAPMSSMRSTAGVA 459
            ..|.|.|.|.|:..||.||||...:         .|..||:::|.:..|:.|||:....|.|.|.
Zfish   376 VARFGHGSAELDHILYVVGGHTSLAGSFPASPSVSLKQVEQYNPQSNKWTLVAPLREGVSNAAVV 440

  Fly   460 VLGGRLYAVGG----RDGSVCHRSIECYDPHTNKWSLLAPMNRRRGGVGVTVANGFLYALGGHDC 520
            ....:|:|.||    ||.   :..::|:||..|:|::.|...:........|....:..:|| |.
Zfish   441 GAKNKLFAFGGTSVNRDK---YPKVQCFDPCENRWTVPATCPQLWRYTAAAVVGNHVVVIGG-DT 501

  Fly   521 PASNPMVCRTETVERYDPATDTWTLICSLALGRDAIGCALLGDRLIVVGGYDGNHALKSVEEYDP 585
            ..|      ..:..|::..|..||....:...|.:......|:||.|||||.|....|:::.|||
Zfish   502 EFS------ASSAYRFNSETFQWTKFGDVTSKRISCHAVASGNRLYVVGGYFGAQRCKTLDCYDP 560

  Fly   586 VRNGWNELAPMAFARAGACVVAIPNVIP 613
            ..:.|:.:..:.::......|:....:|
Zfish   561 STDSWDSITSVPYSLIPTAFVSTWKYLP 588

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17754	NP_572549.2	BTB	70..170	CDD:279045	37/101 (37%)
		PHA03098	71..591	CDD:222983	159/549 (29%)
		BACK	179..281	CDD:285009	30/104 (29%)
		Kelch	323..369	CDD:128874	12/54 (22%)
		KELCH repeat	359..402	CDD:276965	9/44 (20%)
		Kelch	370..416	CDD:128874	13/47 (28%)
		KELCH repeat	406..449	CDD:276965	18/51 (35%)
		Kelch	418..463	CDD:128874	17/53 (32%)
		KELCH repeat	453..497	CDD:276965	15/47 (32%)
		Kelch	464..510	CDD:128874	13/49 (27%)
		Kelch_1	499..546	CDD:279660	9/46 (20%)
		KELCH repeat	500..549	CDD:276965	9/48 (19%)
		KELCH repeat	553..596	CDD:276965	15/42 (36%)
		Kelch	564..610	CDD:128874	14/45 (31%)
enc3	NP_001001402.2	BTB	36..140	CDD:279045	38/106 (36%)
		PHA03098	60..566	CDD:222983	150/528 (28%)
		BACK	149..251	CDD:285009	29/101 (29%)
		Kelch_1	329..374	CDD:279660	10/52 (19%)
		KELCH repeat	330..374	CDD:276965	9/44 (20%)
		KELCH repeat	378..431	CDD:276965	19/52 (37%)
		Kelch	390..440	CDD:128874	16/49 (33%)
		KELCH repeat	434..480	CDD:276965	15/48 (31%)
		Kelch_1	435..479	CDD:279660	15/46 (33%)
		Kelch_1	483..520	CDD:279660	8/43 (19%)
		KELCH repeat	528..570	CDD:276965	15/41 (37%)
		Kelch	539..585	CDD:128874	14/45 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4441
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D709680at2759
OrthoFinder	1	1.000	-	-		FOG0000036
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.820