DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG17754 and keap1a

DIOPT Version :10

Sequence 1:NP_572549.2 Gene:CG17754 / 31873 FlyBaseID:FBgn0030114 Length:654 Species:Drosophila melanogaster
Sequence 2:NP_878284.2 Gene:keap1a / 321837 ZFINID:ZDB-GENE-030131-556 Length:601 Species:Danio rerio


Alignment Length:627 Identity:211/627 - (33%)
Similarity:311/627 - (49%) Gaps:49/627 - (7%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 QKESPSRDSTASTSGHISMLADNTLESLSRDYSLGSLNSAGSQDEFFRCRDHADNILKRMQLYVD 70
            :|:.|.:|...|.....||.....|     ||::.|               |....|:.|.....
Zfish     5 RKKRPIKDEDFSAIVVPSMRGHGYL-----DYTVES---------------HPSKALQNMDELRH 49

  Fly    71 SQQLCDVVLIAGIDGKRV--PAHRLVLSASSAYFSAMFTGSLRETKEQEVTLGEVHGDALHLLVQ 133
            .:.|||:||......|.|  ..|:|||:|||.||.||||.:.:|....||||.:|....:..|:.
Zfish    50 HEMLCDLVLHVTYKDKIVDFKVHKLVLAASSPYFKAMFTSNFKECHASEVTLRDVCPQVISRLID 114

  Fly   134 YCYTGFIEMREDTVETLLATACLLQLNAVVTACCNFLARQLHPSNCLGFAFFAEQQSCTTLLRLA 198
            :.||..|.:.|..|..:|.||...|:..|..|||:||.:.|.|||.:|.:.|||:..||.|....
Zfish   115 FAYTSRITVGETCVLHVLLTAMRYQMEEVAKACCDFLMKNLEPSNVIGISRFAEEIGCTDLHLRT 179

  Fly   199 QAYTCQYFMQVCQNQEFFQLNADQLGKLLSSDDLNVPSEQDVFHSLMSWVRHDSAAREQHIPELL 263
            :.|...:|.:|.:.:|||.|:..||.:|:|.|.|.|..|.:|:.:.:.|||.|:.:|.|:...||
Zfish   180 REYINTHFNEVTKEEEFFSLSHCQLLELISQDSLKVLCESEVYKACIDWVRWDAESRAQYFHALL 244

  Fly   264 ALVRLPLLQPAFIMDHVEN---VCNANECQQLVMEAFKWHLMPERRSRIATERTTPRKSTVGRLL 325
            ..|.:..|.|.|:...:::   :..||.|:..:.:.|  |.|..|:..    ..||.:.|  :|:
Zfish   245 NAVHIYALPPTFLKRQLQSCPILSKANSCKDFLSKIF--HEMALRKPL----PPTPHRGT--QLI 301

  Fly   326 AVGGMDAHKGAISIESYCPRLDKWTPWKHMTGRRLQFGAAVMEDKLILVGGRDGLKTLNTVESLD 390
            .:.|........::|::.|..:.|.....|.......||.|:...|..||||: |...|..||..
Zfish   302 YIAGGYKQHSLDTLEAFDPHKNVWLKLGSMMSPCSGLGACVLFGLLYTVGGRN-LSLQNNTESGS 365

  Fly   391 LN-----TMAWAPLNAMATPRHGLGVAVLEGPLYAVGGHDGWSYLNTVERWDPIARTWSYVAPMS 450
            |:     |..|..|..:.|||:.:||.|::|.:|||||....::.|:|||:||....|::|||||
Zfish   366 LSCYNPMTNQWTQLAPLNTPRNRVGVGVIDGSIYAVGGSHASTHHNSVERYDPETNRWTFVAPMS 430

  Fly   451 SMRSTAGVAVLGGRLYAVGGRDGSVCHRSIECYDPHTNKWSLLAPMNRRRGGVGVTVANGFLYAL 515
            ..|..||||..||.||.|||.||.....::|.|.|.||.|..:||||..|.|:||...:.:|||:
Zfish   431 VARLGAGVAACGGCLYVVGGFDGDNRWNTVERYQPDTNTWQHVAPMNTVRSGLGVVCMDNYLYAV 495

  Fly   516 GGHDCPASNPMVCRTETVERYDPATDTWTLICSLALGRDAIGCALLGDRLIVVGGYDGNHALKSV 580
            ||:|...      :.:|:|||:...|.|..:.|:...|.|.|.::...::.|:||::....|.||
Zfish   496 GGYDGQT------QLKTMERYNITRDVWEPMASMNHCRSAHGVSVYQCKIFVLGGFNQGGFLSSV 554

  Fly   581 EEYDPVRNGWNELAPMAFARAGACVVA----IPNVIPPAAQQ 618
            |.|.|..|.|..:..|...|:|..|..    .|.::|...::
Zfish   555 ECYCPASNVWTLVTDMPVGRSGMGVAVTMEPCPGILPEEEEE 596

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG17754NP_572549.2 PHA03098 71..591 CDD:222983 191/529 (36%)
KELCH repeat 359..402 CDD:276965 16/47 (34%)
KELCH repeat 406..449 CDD:276965 19/42 (45%)
KELCH repeat 453..497 CDD:276965 22/43 (51%)
KELCH repeat 500..549 CDD:276965 16/48 (33%)
KELCH repeat 553..596 CDD:276965 14/42 (33%)
keap1aNP_878284.2 BTB_POZ_KLHL19_KEAP1 33..156 CDD:349557 46/137 (34%)
PHA03098 54..571 CDD:222983 191/531 (36%)
Kelch 1. /evidence=ECO:0000255 292..337 9/46 (20%)
KELCH repeat 336..382 CDD:276965 16/46 (35%)
Kelch 2. /evidence=ECO:0000255 338..388 19/50 (38%)
KELCH repeat 386..429 CDD:276965 19/42 (45%)
Kelch 3. /evidence=ECO:0000255 389..435 22/45 (49%)
KELCH repeat 433..477 CDD:276965 22/43 (51%)
Kelch 4. /evidence=ECO:0000255 436..482 24/45 (53%)
KELCH repeat 480..525 CDD:276965 17/50 (34%)
Kelch 5. /evidence=ECO:0000255 484..529 16/50 (32%)
KELCH repeat 527..572 CDD:276965 15/44 (34%)
Kelch 6. /evidence=ECO:0000255 530..576 14/45 (31%)

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