DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17754 and keap1a

DIOPT Version :9

Sequence 1:	NP_572549.2	Gene:	CG17754 / 31873	FlyBaseID:	FBgn0030114	Length:	654	Species:	Drosophila melanogaster
Sequence 2:	NP_878284.2	Gene:	keap1a / 321837	ZFINID:	ZDB-GENE-030131-556	Length:	601	Species:	Danio rerio

Alignment Length:	627	Identity:	211/627 - (33%)
Similarity:	311/627 - (49%)	Gaps:	49/627 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 QKESPSRDSTASTSGHISMLADNTLESLSRDYSLGSLNSAGSQDEFFRCRDHADNILKRMQLYVD 70
            :|:.|.:|...|.....||.....|     ||::.|               |....|:.|.....
Zfish     5 RKKRPIKDEDFSAIVVPSMRGHGYL-----DYTVES---------------HPSKALQNMDELRH 49

  Fly    71 SQQLCDVVLIAGIDGKRV--PAHRLVLSASSAYFSAMFTGSLRETKEQEVTLGEVHGDALHLLVQ 133
            .:.|||:||......|.|  ..|:|||:|||.||.||||.:.:|....||||.:|....:..|:.
Zfish    50 HEMLCDLVLHVTYKDKIVDFKVHKLVLAASSPYFKAMFTSNFKECHASEVTLRDVCPQVISRLID 114

  Fly   134 YCYTGFIEMREDTVETLLATACLLQLNAVVTACCNFLARQLHPSNCLGFAFFAEQQSCTTLLRLA 198
            :.||..|.:.|..|..:|.||...|:..|..|||:||.:.|.|||.:|.:.|||:..||.|....
Zfish   115 FAYTSRITVGETCVLHVLLTAMRYQMEEVAKACCDFLMKNLEPSNVIGISRFAEEIGCTDLHLRT 179

  Fly   199 QAYTCQYFMQVCQNQEFFQLNADQLGKLLSSDDLNVPSEQDVFHSLMSWVRHDSAAREQHIPELL 263
            :.|...:|.:|.:.:|||.|:..||.:|:|.|.|.|..|.:|:.:.:.|||.|:.:|.|:...||
Zfish   180 REYINTHFNEVTKEEEFFSLSHCQLLELISQDSLKVLCESEVYKACIDWVRWDAESRAQYFHALL 244

  Fly   264 ALVRLPLLQPAFIMDHVEN---VCNANECQQLVMEAFKWHLMPERRSRIATERTTPRKSTVGRLL 325
            ..|.:..|.|.|:...:::   :..||.|:..:.:.|  |.|..|:..    ..||.:.|  :|:
Zfish   245 NAVHIYALPPTFLKRQLQSCPILSKANSCKDFLSKIF--HEMALRKPL----PPTPHRGT--QLI 301

  Fly   326 AVGGMDAHKGAISIESYCPRLDKWTPWKHMTGRRLQFGAAVMEDKLILVGGRDGLKTLNTVESLD 390
            .:.|........::|::.|..:.|.....|.......||.|:...|..||||: |...|..||..
Zfish   302 YIAGGYKQHSLDTLEAFDPHKNVWLKLGSMMSPCSGLGACVLFGLLYTVGGRN-LSLQNNTESGS 365

  Fly   391 LN-----TMAWAPLNAMATPRHGLGVAVLEGPLYAVGGHDGWSYLNTVERWDPIARTWSYVAPMS 450
            |:     |..|..|..:.|||:.:||.|::|.:|||||....::.|:|||:||....|::|||||
Zfish   366 LSCYNPMTNQWTQLAPLNTPRNRVGVGVIDGSIYAVGGSHASTHHNSVERYDPETNRWTFVAPMS 430

  Fly   451 SMRSTAGVAVLGGRLYAVGGRDGSVCHRSIECYDPHTNKWSLLAPMNRRRGGVGVTVANGFLYAL 515
            ..|..||||..||.||.|||.||.....::|.|.|.||.|..:||||..|.|:||...:.:|||:
Zfish   431 VARLGAGVAACGGCLYVVGGFDGDNRWNTVERYQPDTNTWQHVAPMNTVRSGLGVVCMDNYLYAV 495

  Fly   516 GGHDCPASNPMVCRTETVERYDPATDTWTLICSLALGRDAIGCALLGDRLIVVGGYDGNHALKSV 580
            ||:|...      :.:|:|||:...|.|..:.|:...|.|.|.::...::.|:||::....|.||
Zfish   496 GGYDGQT------QLKTMERYNITRDVWEPMASMNHCRSAHGVSVYQCKIFVLGGFNQGGFLSSV 554

  Fly   581 EEYDPVRNGWNELAPMAFARAGACVVA----IPNVIPPAAQQ 618
            |.|.|..|.|..:..|...|:|..|..    .|.::|...::
Zfish   555 ECYCPASNVWTLVTDMPVGRSGMGVAVTMEPCPGILPEEEEE 596

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17754	NP_572549.2	BTB	70..170	CDD:279045	40/101 (40%)
		PHA03098	71..591	CDD:222983	191/529 (36%)
		BACK	179..281	CDD:285009	35/101 (35%)
		Kelch	323..369	CDD:128874	9/45 (20%)
		KELCH repeat	359..402	CDD:276965	16/47 (34%)
		Kelch	370..416	CDD:128874	19/50 (38%)
		KELCH repeat	406..449	CDD:276965	19/42 (45%)
		Kelch	418..463	CDD:128874	22/44 (50%)
		KELCH repeat	453..497	CDD:276965	22/43 (51%)
		Kelch	464..510	CDD:128874	21/45 (47%)
		Kelch_1	499..546	CDD:279660	16/46 (35%)
		KELCH repeat	500..549	CDD:276965	16/48 (33%)
		KELCH repeat	553..596	CDD:276965	14/42 (33%)
		Kelch	564..610	CDD:128874	15/49 (31%)
keap1a	NP_878284.2	BTB_POZ_KLHL19_KEAP1	33..156	CDD:349557	46/137 (34%)
		PHA03098	54..571	CDD:222983	191/531 (36%)
		Kelch 1. /evidence=ECO:0000255	292..337		9/46 (20%)
		KELCH repeat	336..382	CDD:276965	16/46 (35%)
		Kelch 2. /evidence=ECO:0000255	338..388		19/50 (38%)
		KELCH repeat	386..429	CDD:276965	19/42 (45%)
		Kelch 3. /evidence=ECO:0000255	389..435		22/45 (49%)
		KELCH repeat	433..477	CDD:276965	22/43 (51%)
		Kelch 4. /evidence=ECO:0000255	436..482		24/45 (53%)
		KELCH repeat	480..525	CDD:276965	17/50 (34%)
		Kelch 5. /evidence=ECO:0000255	484..529		16/50 (32%)
		KELCH repeat	527..572	CDD:276965	15/44 (34%)
		Kelch 6. /evidence=ECO:0000255	530..576		14/45 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4441
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D312716at33208
OrthoFinder	1	1.000	-	-		FOG0000036
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.820