Protein Alignment CG17754 and Klhl20

DIOPT Version :10

• Sequence 1: NP_572549.2
• Gene: CG17754 / 31873
• FlyBaseID: FBgn0030114
• Length: 654
• Species: Drosophila melanogaster
• Sequence 2: XP_008767871.1
• Gene: Klhl20 / 304920
• RGDID: 1309490
• Length: 633
• Species: Rattus norvegicus
• Alignment Length: 561
• Identity: 236/561 - (42%)
• Similarity: 330/561 - (58%)
• Gaps: 20/561 - (3%)

  Fly    57 HADNILKRMQLYVDSQQLCDVVLIAGIDGKRVPAHRLVLSASSAYFSAMFTGSLRETKEQEVTLG 121
            |....|:.:.|....::||||||:.|  .|::.|||::|||.|.||.|||||.|.|:::.||.:.
  Rat    74 HPRQTLEVINLLRKHRELCDVVLVVG--AKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIR 136

  Fly   122 EVHGDALHLLVQYCYTGFIEMREDTVETLLATACLLQLNAVVTACCNFLARQLHPSNCLGFAFFA 186
            ::...|:.||:.:.||..|.:.|..|:|||..||||||..:..|||.||.|||.||||||...||
  Rat   137 DIDERAMELLIDFAYTSQITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQLDPSNCLGIRAFA 201

  Fly   187 EQQSCTTLLRLAQAYTCQYFMQVCQNQEFFQLNADQLGKLLSSDDLNVPSEQDVFHSLMSWVRHD 251
            :..||..|||:|..:|...|.:|.:::||..|.|:||..::|||:|||.||:.||:::|:||::.
  Rat   202 DTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYS 266

  Fly   252 SAAREQHIPELLALVRLPLLQPAFIMDHVEN---VCNANECQQLVMEAFKWHLMPERRSRIATER 313
            ...|...:|::|..||||||.|.|::..|.:   :.:..||:.||.||..:.|:|:.|..:...|
  Rat   267 IQERRPQLPQVLQHVRLPLLSPKFLVGTVGSDPLIKSDEECRDLVDEAKNYLLLPQERPLMQGPR 331

  Fly   314 TTPRKS-TVGRLL-AVGGMDAHKGAISIESYCPRLDKWTPWKHMTGRRLQFGAAVMEDKLILVGG 376
            |.|||. ..|.:| ||||..:.....|:|.|.|:.::|.....|:.||...|.:|::|.|..|||
  Rat   332 TRPRKPIRCGEVLFAVGGWCSGDAISSVERYDPQTNEWRMVASMSKRRCGVGVSVLDDLLYAVGG 396

  Fly   377 RDGLKTLNTVESLDLNTMAW----APLNAMATPRHGLGVAVLEGPLYAVGGHDGWSYLNTVERWD 437
            .||...||:||..|..|..|    ||   .:|.|..:|||||.|.||||||.||.|.||.|||:|
  Rat   397 HDGSSYLNSVERYDPKTNQWSSDVAP---TSTCRTSVGVAVLGGFLYAVGGQDGVSCLNIVERYD 458

  Fly   438 PIARTWSYVAPMSSMRSTAGVAVLGGRLYAVGGRDGSVCHRSIECYDPHTNKWSLLAPMNRRRGG 502
            |....|:.||.||:.|....||||||.||||||.||:....::|.|:|..|:|..:|||..||..
  Rat   459 PKENKWTRVASMSTRRLGVAVAVLGGFLYAVGGSDGTSPLNTVERYNPQENRWHTIAPMGTRRKH 523

  Fly   503 VGVTVANGFLYALGGHDCPASNPMVCRTETVERYDPATDTWTLICSLALGRDAIGCALLGDRLIV 567
            :|..|....:||:||.|      ......:.|||:|.|:.|:.:.::...|..:|.|::..:|:.
  Rat   524 LGCAVYQDMIYAVGGRD------DTTELSSAERYNPRTNQWSPVVAMTSRRSGVGLAVVNGQLMA 582

  Fly   568 VGGYDGNHALKSVEEYDPVRNGWNELAPMAFARAGACVVAI 608
            |||:||...||::|.:||..|.|.....|.:.|.|..|..|
  Rat   583 VGGFDGTTYLKTIEVFDPDANTWRLYGGMNYRRLGGGVGVI 623

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG17754	NP_572549.2	PHA03098	71..591	CDD:222983	227/528 (43%)
		KELCH repeat	359..402	CDD:276965	19/46 (41%)
		KELCH repeat	406..449	CDD:276965	26/42 (62%)
		KELCH repeat	453..497	CDD:276965	22/43 (51%)
		KELCH repeat	500..549	CDD:276965	14/48 (29%)
		KELCH repeat	553..596	CDD:276965	16/42 (38%)
Klhl20	XP_008767871.1	BTB_POZ_KLHL20_KLEIP	69..196	CDD:349558	58/123 (47%)
		PHA03098	87..610	CDD:222983	228/533 (43%)
		KELCH repeat	379..423	CDD:276965	19/46 (41%)
		KELCH repeat	427..471	CDD:276965	26/43 (60%)
		KELCH repeat	474..519	CDD:276965	23/44 (52%)
		KELCH repeat	521..564	CDD:276965	14/48 (29%)
		KELCH repeat	568..613	CDD:276965	17/44 (39%)