DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17754 and Klhl20

DIOPT Version :9

Sequence 1:	NP_572549.2	Gene:	CG17754 / 31873	FlyBaseID:	FBgn0030114	Length:	654	Species:	Drosophila melanogaster
Sequence 2:	XP_008767871.1	Gene:	Klhl20 / 304920	RGDID:	1309490	Length:	633	Species:	Rattus norvegicus

Alignment Length:	561	Identity:	236/561 - (42%)
Similarity:	330/561 - (58%)	Gaps:	20/561 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 HADNILKRMQLYVDSQQLCDVVLIAGIDGKRVPAHRLVLSASSAYFSAMFTGSLRETKEQEVTLG 121
            |....|:.:.|....::||||||:.|  .|::.|||::|||.|.||.|||||.|.|:::.||.:.
  Rat    74 HPRQTLEVINLLRKHRELCDVVLVVG--AKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIR 136

  Fly   122 EVHGDALHLLVQYCYTGFIEMREDTVETLLATACLLQLNAVVTACCNFLARQLHPSNCLGFAFFA 186
            ::...|:.||:.:.||..|.:.|..|:|||..||||||..:..|||.||.|||.||||||...||
  Rat   137 DIDERAMELLIDFAYTSQITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQLDPSNCLGIRAFA 201

  Fly   187 EQQSCTTLLRLAQAYTCQYFMQVCQNQEFFQLNADQLGKLLSSDDLNVPSEQDVFHSLMSWVRHD 251
            :..||..|||:|..:|...|.:|.:::||..|.|:||..::|||:|||.||:.||:::|:||::.
  Rat   202 DTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYS 266

  Fly   252 SAAREQHIPELLALVRLPLLQPAFIMDHVEN---VCNANECQQLVMEAFKWHLMPERRSRIATER 313
            ...|...:|::|..||||||.|.|::..|.:   :.:..||:.||.||..:.|:|:.|..:...|
  Rat   267 IQERRPQLPQVLQHVRLPLLSPKFLVGTVGSDPLIKSDEECRDLVDEAKNYLLLPQERPLMQGPR 331

  Fly   314 TTPRKS-TVGRLL-AVGGMDAHKGAISIESYCPRLDKWTPWKHMTGRRLQFGAAVMEDKLILVGG 376
            |.|||. ..|.:| ||||..:.....|:|.|.|:.::|.....|:.||...|.:|::|.|..|||
  Rat   332 TRPRKPIRCGEVLFAVGGWCSGDAISSVERYDPQTNEWRMVASMSKRRCGVGVSVLDDLLYAVGG 396

  Fly   377 RDGLKTLNTVESLDLNTMAW----APLNAMATPRHGLGVAVLEGPLYAVGGHDGWSYLNTVERWD 437
            .||...||:||..|..|..|    ||   .:|.|..:|||||.|.||||||.||.|.||.|||:|
  Rat   397 HDGSSYLNSVERYDPKTNQWSSDVAP---TSTCRTSVGVAVLGGFLYAVGGQDGVSCLNIVERYD 458

  Fly   438 PIARTWSYVAPMSSMRSTAGVAVLGGRLYAVGGRDGSVCHRSIECYDPHTNKWSLLAPMNRRRGG 502
            |....|:.||.||:.|....||||||.||||||.||:....::|.|:|..|:|..:|||..||..
  Rat   459 PKENKWTRVASMSTRRLGVAVAVLGGFLYAVGGSDGTSPLNTVERYNPQENRWHTIAPMGTRRKH 523

  Fly   503 VGVTVANGFLYALGGHDCPASNPMVCRTETVERYDPATDTWTLICSLALGRDAIGCALLGDRLIV 567
            :|..|....:||:||.|      ......:.|||:|.|:.|:.:.::...|..:|.|::..:|:.
  Rat   524 LGCAVYQDMIYAVGGRD------DTTELSSAERYNPRTNQWSPVVAMTSRRSGVGLAVVNGQLMA 582

  Fly   568 VGGYDGNHALKSVEEYDPVRNGWNELAPMAFARAGACVVAI 608
            |||:||...||::|.:||..|.|.....|.:.|.|..|..|
  Rat   583 VGGFDGTTYLKTIEVFDPDANTWRLYGGMNYRRLGGGVGVI 623

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17754	NP_572549.2	BTB	70..170	CDD:279045	46/99 (46%)
		PHA03098	71..591	CDD:222983	227/528 (43%)
		BACK	179..281	CDD:285009	44/101 (44%)
		Kelch	323..369	CDD:128874	15/46 (33%)
		KELCH repeat	359..402	CDD:276965	19/46 (41%)
		Kelch	370..416	CDD:128874	22/49 (45%)
		KELCH repeat	406..449	CDD:276965	26/42 (62%)
		Kelch	418..463	CDD:128874	26/44 (59%)
		KELCH repeat	453..497	CDD:276965	22/43 (51%)
		Kelch	464..510	CDD:128874	20/45 (44%)
		Kelch_1	499..546	CDD:279660	15/46 (33%)
		KELCH repeat	500..549	CDD:276965	14/48 (29%)
		KELCH repeat	553..596	CDD:276965	16/42 (38%)
		Kelch	564..610	CDD:128874	18/45 (40%)
Klhl20	XP_008767871.1	BTB	83..186	CDD:279045	48/104 (46%)
		PHA03098	87..610	CDD:222983	228/533 (43%)
		BACK	194..295	CDD:285009	44/100 (44%)
		Kelch	343..389	CDD:128874	15/45 (33%)
		KELCH repeat	379..423	CDD:276965	19/46 (41%)
		Kelch	390..437	CDD:128874	22/49 (45%)
		KELCH repeat	427..471	CDD:276965	26/43 (60%)
		Kelch	439..484	CDD:128874	26/44 (59%)
		KELCH repeat	474..519	CDD:276965	23/44 (52%)
		Kelch	486..531	CDD:128874	20/44 (45%)
		KELCH repeat	521..564	CDD:276965	14/48 (29%)
		Kelch	533..578	CDD:128874	14/50 (28%)
		Kelch_1	567..612	CDD:279660	16/44 (36%)
		KELCH repeat	568..613	CDD:276965	17/44 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4441
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D312716at33208
OrthoFinder	1	1.000	-	-		FOG0000036
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.820