DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG17754 and Ipp

DIOPT Version :9

Sequence 1:	NP_572549.2	Gene:	CG17754 / 31873	FlyBaseID:	FBgn0030114	Length:	654	Species:	Drosophila melanogaster
Sequence 2:	NP_001100149.2	Gene:	Ipp / 298439	RGDID:	1306299	Length:	584	Species:	Rattus norvegicus

Alignment Length:	585	Identity:	194/585 - (33%)
Similarity:	281/585 - (48%)	Gaps:	28/585 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 AGSQDEFFRCRDHADNILKRMQLYVDSQQLCDVVLIAGIDGKRVPAHRLVLSASSAYFSAMFTGS 109
            |.:.|..|....||..||.:|......|..|||.|..|.:..:|  |||||:|||.||:|:|||.
  Rat     7 AKAADSSFSSDKHAQLILAQMNKMRTGQHFCDVQLQVGKETFQV--HRLVLAASSPYFAALFTGG 69

  Fly   110 LRETKEQEVTLGEVHGDALHLLVQYCYTGFIEMREDTVETLLATACLLQLNAVVTACCNFLARQL 174
            ::|:.:..|.:..|......||:.:.|||.:.:....|:.|:..|.:|||..||..||:||..|:
  Rat    70 MKESSKDVVQILGVEAGIFQLLLDFIYTGLVNIAVSNVQELIVAADMLQLTEVVNLCCDFLKGQI 134

  Fly   175 HPSNCLGFAFFAEQQSCTTLLRLAQAYTCQYFMQVCQNQEFFQLNADQLGKLLSSDDLNVPSEQD 239
            .|.||:|...|:||.:|..||...:.|...:|::|...:||..|..|||.::|.|::|::..|..
  Rat   135 DPQNCIGLFQFSEQIACHDLLEFTENYIHVHFLEVHSGEEFLALTKDQLIRILRSEELSIEDEYQ 199

  Fly   240 VFHSLMSWVRHDSAAREQHIPELLALVRLPLLQPAFIMDHVENVCNAN---ECQQLVMEAFKWHL 301
            ||.:.|.|:..|...|.:|:.|:|..||.|||....::.::|.|.:.|   ..|.|:.|..:...
  Rat   200 VFLAAMQWILKDLGKRRKHVVEVLDPVRFPLLPSQRLLKYIEGVSDFNLRVALQTLLKEYCEVCK 264

  Fly   302 MPERR---SRIATERTTPRKSTVGRLLAVGGMDAHKG-------AIS-IESYCPRLDKWTPWKHM 355
            .|:..   |.:.|.:..|||.....|.||||....:|       |:| :|.:......||....:
  Rat   265 SPKENKFCSFLQTSKARPRKKARKYLYAVGGYTRLQGGRWSDSRALSCVERFDTFSQYWTTVSSL 329

  Fly   356 TGRRLQFGAAVMEDKLILVGGRDGLKTLNTVESLDLNTMAWAPLNAMATPRHGLGVAVLEGPLYA 420
            ...|...|.||:...:..:||.......:..|..|..|..|..:.:|..||.||||.|..|.:||
  Rat   330 HQARCGLGVAVLGGMVYAIGGEKDSMIFDCTECYDPVTKQWTTVASMNHPRCGLGVCVCYGAIYA 394

  Fly   421 VGGHDGWSYLNTVERWDPIARTWSYVAPMSSMRSTAGVAVLGGRLYAVGGRDGSVCH-RSIECYD 484
            :||..|....:|:||:||....|..|..|:..|...|...:.|.:|||||....... ||.|.||
  Rat   395 LGGWVGAEIGDTIERFDPDENKWEVVGNMAVSRYYFGCCEMQGLIYAVGGISNEGLELRSFEVYD 459

  Fly   485 PHTNKWSLLAPMNRRRGGVGVTVANGFLYALGGHDCPASNPMVCRTETVERYDPATDTWTLICSL 549
            |.:.:||.|.||..||..:||...|..:||:||.     |.......|||:|....:.|..:.|:
  Rat   460 PLSKRWSPLPPMGTRRAYLGVAALNDCIYAIGGW-----NETQDALHTVEKYSFEEEKWIEVASM 519

  Fly   550 ALGRDAIGCALLGDRLIVVGGYDGNH------ALKSVEEYDPVRNGWNELAPMAFARAGACVVAI 608
            .:.|..:....:...|.|.||...:|      .|.|||.|:|..:.|.|:..|..:|....|..:
  Rat   520 KVPRAGMCVVAVNGLLYVSGGRSSSHDFLAPGTLDSVEVYNPHSDTWTEIGNMITSRCEGGVAVL 584

Fly 609 608
Rat 585 584

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17754	NP_572549.2	BTB	70..170	CDD:279045	39/99 (39%)
		PHA03098	71..591	CDD:222983	181/540 (34%)
		BACK	179..281	CDD:285009	35/101 (35%)
		Kelch	323..369	CDD:128874	15/53 (28%)
		KELCH repeat	359..402	CDD:276965	10/42 (24%)
		Kelch	370..416	CDD:128874	14/45 (31%)
		KELCH repeat	406..449	CDD:276965	19/42 (45%)
		Kelch	418..463	CDD:128874	15/44 (34%)
		KELCH repeat	453..497	CDD:276965	18/44 (41%)
		Kelch	464..510	CDD:128874	20/46 (43%)
		Kelch_1	499..546	CDD:279660	15/46 (33%)
		KELCH repeat	500..549	CDD:276965	14/48 (29%)
		KELCH repeat	553..596	CDD:276965	14/48 (29%)
		Kelch	564..610	CDD:128874	16/51 (31%)
Ipp	NP_001100149.2	BTB_POZ_KLHL27_IPP	17..141	CDD:349565	50/125 (40%)
		PHA03098	34..575	CDD:222983	184/547 (34%)
		KELCH repeat	333..376	CDD:276965	10/42 (24%)
		KELCH repeat	380..424	CDD:276965	19/43 (44%)
		KELCH repeat	427..473	CDD:276965	19/45 (42%)
		KELCH repeat	475..520	CDD:276965	15/49 (31%)
		KELCH repeat	523..574	CDD:276965	15/50 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4441
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D312716at33208
OrthoFinder	1	1.000	-	-		FOG0000036
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.820