DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG17754 and Enc1

DIOPT Version :9

Sequence 1:	NP_572549.2	Gene:	CG17754 / 31873	FlyBaseID:	FBgn0030114	Length:	654	Species:	Drosophila melanogaster
Sequence 2:	NP_001003401.1	Gene:	Enc1 / 294674	RGDID:	1303152	Length:	589	Species:	Rattus norvegicus

Alignment Length:	592	Identity:	175/592 - (29%)
Similarity:	276/592 - (46%)	Gaps:	56/592 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 SLGSLNSAGSQDEFFRCRDHADNILKRMQLYVDSQQLCDVVLIAGIDGKRVPAHRLVLSASSAYF 102
            |.||:|.     ..|....:||::|..:.|....:...||:|.||  .:..|.||.||:|.|.||
  Rat    14 SSGSINI-----YLFHKSSYADSVLTHLNLLRQQRLFTDVLLHAG--NRTFPCHRAVLAACSRYF 71

  Fly   103 SAMFTGSLRETKEQEVTL-GEVHGDALHLLVQYCYTGFIEMREDTVETLLATACLLQLNAVVTAC 166
            .|||:|.|:|:::.||.. ..:|.:.|.||:.|.|:..:.:.|:..|:||....:|:...:..||
  Rat    72 EAMFSGGLKESQDSEVNFDNSIHPEVLELLLDYAYSSRVIINEENAESLLEAGDMLEFQDIRDAC 136

  Fly   167 CNFLARQLHPSNCLGFAFFAEQQSCTTLLRLAQAYTCQYFMQVCQNQEFFQLNADQLGKLLSSDD 231
            ..||.:.|||:||||....::...||.|..|:.......|..:.:|::|.||..|.:.:||||::
  Rat   137 AEFLEKNLHPTNCLGMLLLSDAHQCTKLYELSWRMCLSNFQTIRKNEDFLQLPQDMVVQLLSSEE 201

  Fly   232 LNVPSEQDVFHSLMSWVRHDSAAREQHIPELLALVRLPLLQPAFIMDHV---ENVCNANECQQLV 293
            |....|:.|:.|.|:|:.:|...|..::||||..|||.||...::|::|   |.:....:.:::|
  Rat   202 LETEDERLVYESAMNWISYDLKKRYCYLPELLQTVRLALLPAIYLMENVAMEELITKQRKSKEIV 266

  Fly   294 MEAFKWHLMPERRSRIATERTTPRKSTVGRLLAVGGMDAHKGAISI-----ESYCPRLDKWTPWK 353
            .||.:..|...:...:.|......:.|...|..:||.......:.:     :...|:.|..:|
  Rat   267 EEAIRCKLKILQNDGVVTSLCARPRKTGHALFLLGGQTFMCDKLYLVDQKAKEIIPKADIPSP-- 329

  Fly   354 HMTGRRLQFGAAVMEDKLILVGGR---DGLKTLNTVESLDLNTMAWAPLNAMATPRHGLGVAVLE 415
                 |.:|.|..:..|:.:.|||   :|:.  ..|...|.....|:....|...|.|.|.|.|:
  Rat   330 -----RKEFSACAIGCKVYITGGRGSENGVS--KDVWVYDTLHEEWSKAAPMLVARFGHGSAELK 387

  Fly   416 GPLYAVGGHDGWS---------YLNTVERWDPIARTWSYVAPMSSMRSTAGVAVLGGRLYAVGGR 471
            ..||.||||...:         .|..||::||....|:.|||:....|.|.|.....:|:|.||.
  Rat   388 HCLYVVGGHTAATGCLPASPSVSLKQVEQYDPTTNKWTMVAPLREGVSNAAVVSAKLKLFAFGGT 452

  Fly   472 DGSVCH---RSIECYDPHTNKWSLLAPMNRRRGGVGVTVANGFLYALGGHDCPASNPMVCRTETV 533
              ||.|   ..::|||...|:|::.|...:........|....::.:|| |...|   .|   :.
  Rat   453 --SVSHDKLPKVQCYDQCENRWTVPATCPQPWRYTAAAVLGNQIFIMGG-DTEFS---AC---SA 508

  Fly   534 ERYDPATDTWTLICSLALGRDAIGCALLGDRLIVVGGYDGNHALKSVEEYDPVRNGWN------- 591
            .:::..|..||.:..:...|.:......|::|.|||||.|....|:::.|||..:.||
  Rat   509 YKFNSETYQWTKVGDVTAKRMSCHAVASGNKLYVVGGYFGIQRCKTLDCYDPTLDVWNSITTVPY 573

  Fly   592 ELAPMAF 598
            .|.|.||
  Rat   574 SLIPTAF 580

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17754	NP_572549.2	BTB	70..170	CDD:279045	35/100 (35%)
		PHA03098	71..591	CDD:222983	160/543 (29%)
		BACK	179..281	CDD:285009	36/104 (35%)
		Kelch	323..369	CDD:128874	9/50 (18%)
		KELCH repeat	359..402	CDD:276965	11/45 (24%)
		Kelch	370..416	CDD:128874	14/48 (29%)
		KELCH repeat	406..449	CDD:276965	19/51 (37%)
		Kelch	418..463	CDD:128874	18/53 (34%)
		KELCH repeat	453..497	CDD:276965	16/46 (35%)
		Kelch	464..510	CDD:128874	14/48 (29%)
		Kelch_1	499..546	CDD:279660	9/46 (20%)
		KELCH repeat	500..549	CDD:276965	9/48 (19%)
		KELCH repeat	553..596	CDD:276965	16/49 (33%)
		Kelch	564..610	CDD:128874	17/42 (40%)
Enc1	NP_001003401.1	BTB	36..140	CDD:279045	36/105 (34%)
		PHA03098	48..566	CDD:222983	159/537 (30%)
		BACK	149..251	CDD:285009	35/101 (35%)
		Kelch_1	329..374	CDD:279660	12/53 (23%)
		KELCH repeat	330..374	CDD:276965	11/45 (24%)
		KELCH repeat	378..431	CDD:276965	20/52 (38%)
		Kelch	389..441	CDD:128874	18/51 (35%)
		KELCH repeat	434..480	CDD:276965	16/47 (34%)
		Kelch_1	481..523	CDD:279660	9/48 (19%)
		KELCH repeat	528..568	CDD:276965	15/39 (38%)
		Kelch	539..585	CDD:128874	17/42 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4441
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D709680at2759
OrthoFinder	1	1.000	-	-		FOG0000036
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.820