DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG17754 and Klhl25

DIOPT Version :10

Sequence 1:NP_572549.2 Gene:CG17754 / 31873 FlyBaseID:FBgn0030114 Length:654 Species:Drosophila melanogaster
Sequence 2:NP_001034095.1 Gene:Klhl25 / 293023 RGDID:1310815 Length:589 Species:Rattus norvegicus


Alignment Length:634 Identity:189/634 - (29%)
Similarity:287/634 - (45%) Gaps:95/634 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly    22 ISMLADNTLESLSRDYSLGSLNSAGSQDEFFRCRDHADNILKRMQLYVDSQQLCDVVLIAGIDGK 86
            :|:....|.:|.|   |.||:|.:     .|....|.|.:|..:..........||.|.||  .:
  Rat     1 MSVSVHETRKSRS---STGSMNIS-----VFHKASHPDCVLAHLNTLRKHCMFTDVTLWAG--DR 55

  Fly    87 RVPAHRLVLSASSAYFSAMFTGSLRETKEQEVTLGE-VHGDALHLLVQYCYTGFIEMREDTVETL 150
            ..|.||.||:|||.||.|||:..|||:::..|...: :|.:.|.||:.:.|:..|.:.|:..|:|
  Rat    56 AFPCHRAVLAASSRYFEAMFSHGLRESRDDTVNFQDNLHPEVLELLLDFAYSSRIVINEENAESL 120

  Fly   151 LATACLLQLNAVVTACCNFLARQLHPSNCLGFAFFAEQQSCTTLLRLAQAYTCQYFMQVCQNQEF 215
            |....:||.:.|..|...||.:.|.||||||....::...|..|...:...:..:|..|.|:::|
  Rat   121 LEAGDMLQFHDVRDAAAEFLEKNLSPSNCLGMMVLSDAHQCRRLYEFSCRMSLVHFETVRQSEDF 185

  Fly   216 FQLNADQLGKLLSSDDLNVPSEQDVFHSLMSWVRHDSAAREQHIPELLALVRLPLLQPAFIMDHV 280
            ..|:.|.|..|:|.|:|....|:.||.:::.||:||...|:.|:|.||..|||.||....:...|
  Rat   186 NSLSRDTLLDLISRDELETEDERVVFEAILQWVKHDLEQRKVHLPLLLRNVRLALLPSDCLKKAV 250

  Fly   281 --ENVCNANECQQLVM-EAFKWHLMPERRSRIATER-TTPRKSTVGR-LLAVGGMD--------- 331
              |.:..|:||.:|:: |||:..........:.|.. ..|||:  |. ||.:||..         
  Rat   251 SGEALLMADECTKLIIDEAFRCKTKILLNDGVVTSPFARPRKA--GHTLLILGGQTFMCDKIYQV 313

  Fly   332 AHKGAISIESYCPRLDKWTPWKHMTGRRLQFGAAVMEDKLILVGGR---DGLK----TLNTVESL 389
            .||.    :...|:.|..:|       |.:|.|:.:..|:.:.|||   :|:.    ..:||.. 
  Rat   314 DHKA----KEIIPKADLPSP-------RKEFSASAIGCKVYVTGGRGSENGVSKDVWVYDTVHE- 366

  Fly   390 DLNTMAWAPLNAMATPRHGLGVAVLEGPLYAVGGHDGWS---------YLNTVERWDPIARTWSY 445
                 .|:....|...|.|.|.|.||..||.||||...:         .|..||::||....|:.
  Rat   367 -----EWSKAAPMLIARFGHGSAELENCLYVVGGHTSLAGIFPASPSVSLKQVEKYDPGDNKWTM 426

  Fly   446 VAPMSSMRSTAGVAVLGGRLYAVGGRDGSVCHR----SIECYDPHTNKWSLLAPMNRRRGGVGVT 506
            ||||....|.|.|.....:|:..|   |:..||    .::|:||..|:|::.|...:........
  Rat   427 VAPMRDGVSNAAVVSAKLKLFVFG---GTSIHRDMVSKVQCFDPSDNRWTIKAECPQPWRYTAAA 488

  Fly   507 VANGFLYALGGHDCPASNPMVCRTE----TVERYDPATDTWTLICSLALGRDAIGCALLGDRLIV 567
            |....::.:||.           ||    :..|:|..|:.||.|..:...|.:......|::|.|
  Rat   489 VLGSQIFIMGGD-----------TEYTAASAYRFDCETNQWTRIGDMTAKRMSCHAVASGNKLYV 542

  Fly   568 VGGYDGNHALKSVEEYDPVRNGWNELAPMAFARAGACVVAIP-NVIPPA 615
            ||||.|....|:::.|||..:.||            |:.::| ::||.|
  Rat   543 VGGYFGTQRCKTLDCYDPTSDTWN------------CITSVPYSLIPTA 579

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG17754NP_572549.2 PHA03098 71..591 CDD:222983 170/558 (30%)
KELCH repeat 359..402 CDD:276965 11/49 (22%)
KELCH repeat 406..449 CDD:276965 20/51 (39%)
KELCH repeat 453..497 CDD:276965 14/47 (30%)
KELCH repeat 500..549 CDD:276965 11/52 (21%)
KELCH repeat 553..596 CDD:276965 15/42 (36%)
Klhl25NP_001034095.1 BTB_POZ_KLHL25 24..151 CDD:349563 46/128 (36%)
PHA03098 39..566 CDD:222983 170/561 (30%)
Kelch 1 296..340 12/54 (22%)
KELCH repeat 330..374 CDD:276965 11/49 (22%)
Kelch 2 341..388 14/52 (27%)
KELCH repeat 378..431 CDD:276965 21/52 (40%)
Kelch 3 389..444 19/54 (35%)
KELCH repeat 434..480 CDD:276965 14/48 (29%)
Kelch 4 446..492 12/48 (25%)
KELCH repeat 482..525 CDD:276965 11/53 (21%)
Kelch 5 493..538 11/55 (20%)
KELCH repeat 528..573 CDD:276965 16/56 (29%)
Kelch 6 539..585 18/53 (34%)

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