DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17754 and Klhl1

DIOPT Version :9

Sequence 1:	NP_572549.2	Gene:	CG17754 / 31873	FlyBaseID:	FBgn0030114	Length:	654	Species:	Drosophila melanogaster
Sequence 2:	NP_001381602.1	Gene:	Klhl1 / 290426	RGDID:	1307452	Length:	750	Species:	Rattus norvegicus

Alignment Length:	611	Identity:	328/611 - (53%)
Similarity:	422/611 - (69%)	Gaps:	13/611 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSAVNQKESPSRDSTASTSGHISMLADNTLESLSRDYSLGSLNSAGSQDEFFRCRDHADNILKRM 65
            :..:..:.:.|..:|....||   ....|..||:....|.|    .|.:||::...||:...::|
  Rat   147 LKELQAEPASSIQATGEGCGH---RLTTTNHSLTPQSDLDS----SSSEEFYQAVHHAEQSFRKM 204

  Fly    66 QLYVDSQQLCDVVLIAGIDGKRVPAHRLVLSASSAYFSAMFTGSLRETKEQEVTLGEVHGDALHL 130
            :.|:..||||||:||.|  .:::||||||||:.|.||:||||..:.|.|::|:.:..:..:||..
  Rat   205 ENYLKQQQLCDVILIVG--NRKIPAHRLVLSSVSDYFAAMFTSDVCEAKQEEIKMEGIDPNALWD 267

  Fly   131 LVQYCYTGFIEMREDTVETLLATACLLQLNAVVTACCNFLARQLHPSNCLGFAFFAEQQSCTTLL 195
            |||:.|||.:|::|||:|.|||.||||||..||..||:||.:.||||||||...||:.|.|..|:
  Rat   268 LVQFAYTGCLELKEDTIENLLAAACLLQLPQVVEVCCHFLMKLLHPSNCLGIRAFADAQGCIELM 332

  Fly   196 RLAQAYTCQYFMQVCQNQEFFQLNADQLGKLLSSDDLNVPSEQDVFHSLMSWVRHDSAAREQHIP 260
            ::|.:||.:..|:|.:||||..|.|::|.|||:|||:|||.|:.:||:||.||::|...|...:.
  Rat   333 KVAHSYTMENIMEVIRNQEFLLLPAEELHKLLASDDVNVPDEETIFHALMMWVKYDMQRRCGDLS 397

  Fly   261 ELLALVRLPLLQPAFIMDHVENVC---NANECQQLVMEAFKWHLMPERRSRIATERTTPRKSTVG 322
            .|||.:|||||.|..:.| :||..   |..|||:|::||.|:||:||||:.:.:.||.|||||||
  Rat   398 MLLAFIRLPLLPPQILAD-LENHALFKNDLECQKLILEAMKYHLLPERRTLMQSPRTKPRKSTVG 461

  Fly   323 RLLAVGGMDAHKGAISIESYCPRLDKWTPWKHMTGRRLQFGAAVMEDKLILVGGRDGLKTLNTVE 387
            .|.||||||.:|||.:||.|..|.:.|.....|.|||||||.||::|||.::|||||||||||||
  Rat   462 TLYAVGGMDNNKGATTIEKYDLRTNLWIQAGMMNGRRLQFGVAVIDDKLFVIGGRDGLKTLNTVE 526

  Fly   388 SLDLNTMAWAPLNAMATPRHGLGVAVLEGPLYAVGGHDGWSYLNTVERWDPIARTWSYVAPMSSM 452
            ..:..|..|..|..|:|.||||||.|||||:||||||||||||||||||||.::.|:|||.||..
  Rat   527 CYNPKTKTWTVLPPMSTHRHGLGVTVLEGPIYAVGGHDGWSYLNTVERWDPQSQQWTYVASMSIA 591

  Fly   453 RSTAGVAVLGGRLYAVGGRDGSVCHRSIECYDPHTNKWSLLAPMNRRRGGVGVTVANGFLYALGG 517
            |||.|||.|.|:||:|||||||.|..|:|.|||||||||:.|||.:|||||||...:|||||:||
  Rat   592 RSTVGVAALNGKLYSVGGRDGSSCLSSMEYYDPHTNKWSMCAPMCKRRGGVGVATCDGFLYAVGG 656

  Fly   518 HDCPASNPMVCRTETVERYDPATDTWTLICSLALGRDAIGCALLGDRLIVVGGYDGNHALKSVEE 582
            ||.||||......:.||||||.|||||::..|::.|||:|..||||||..||||||...|.::|.
  Rat   657 HDAPASNHCSRLLDYVERYDPKTDTWTMVAPLSMPRDAVGVCLLGDRLYAVGGYDGQTYLNTMES 721

  Fly   583 YDPVRNGWNELAPMAFARAGACVVAI 608
            |||..|.|.::|.:...|||||||.|
  Rat   722 YDPQTNEWTQMASLNIGRAGACVVVI 747

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17754	NP_572549.2	BTB	70..170	CDD:279045	53/99 (54%)
		PHA03098	71..591	CDD:222983	302/522 (58%)
		BACK	179..281	CDD:285009	48/101 (48%)
		Kelch	323..369	CDD:128874	25/45 (56%)
		KELCH repeat	359..402	CDD:276965	26/42 (62%)
		Kelch	370..416	CDD:128874	28/45 (62%)
		KELCH repeat	406..449	CDD:276965	35/42 (83%)
		Kelch	418..463	CDD:128874	33/44 (75%)
		KELCH repeat	453..497	CDD:276965	31/43 (72%)
		Kelch	464..510	CDD:128874	31/45 (69%)
		Kelch_1	499..546	CDD:279660	31/46 (67%)
		KELCH repeat	500..549	CDD:276965	30/48 (63%)
		KELCH repeat	553..596	CDD:276965	24/42 (57%)
		Kelch	564..610	CDD:128874	24/45 (53%)
Klhl1	NP_001381602.1	PHA03098	208..730	CDD:222983	302/524 (58%)
		KELCH repeat	498..541	CDD:276965	26/42 (62%)
		KELCH repeat	545..589	CDD:276965	35/43 (81%)
		KELCH repeat	592..635	CDD:276965	30/42 (71%)
		KELCH repeat	639..689	CDD:276965	30/49 (61%)
		KELCH repeat	692..736	CDD:276965	24/43 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	118	1.000	Domainoid score	I5703
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48972
OrthoDB	1	1.010	-	-		D312716at33208
OrthoFinder	1	1.000	-	-		FOG0000036
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_104433
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.830