DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17754 and Klhl8

DIOPT Version :9

Sequence 1:	NP_572549.2	Gene:	CG17754 / 31873	FlyBaseID:	FBgn0030114	Length:	654	Species:	Drosophila melanogaster
Sequence 2:	NP_001099465.1	Gene:	Klhl8 / 289457	RGDID:	1304685	Length:	621	Species:	Rattus norvegicus

Alignment Length:	612	Identity:	215/612 - (35%)
Similarity:	318/612 - (51%)	Gaps:	45/612 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 MLADNTLESLSRDY---------------SLGSLNSAGSQDEF-FRCRDHADNILKRMQLYVDSQ 72
            |.:::|...|:|.:               |..|::.....|.| |...:...:....:..:.::.
  Rat     1 MASESTNGKLARSHVTKGRRQQQQQQQVRSRSSVSECDGDDSFIFEANEAWKDFHGSLLGFYENG 65

  Fly    73 QLCDVVLIAGIDGKRVPAHRLVLSASSAYFSAMFTGSLRETKEQEVTLGEVHGDALHLLVQYCYT 137
            :||||.|..|  .|.:..|:|.|:....||.|||...:.|.|:..:.:.:..|||:..||::.|:
  Rat    66 ELCDVTLKVG--SKLISCHKLALACVIPYFRAMFLSEMSEAKQALIEIRDFDGDAVEDLVKFVYS 128

  Fly   138 GFIEMREDTVETLLATACLLQLNAVVTACCNFLARQLHPSNCLGFAFFAEQQSCTTLLRLAQAYT 202
            ..:.:..|.|:.||..||:||:..|..|||.::....||||||....|||..:.|.|:.:|..|.
  Rat   129 SRLTLTVDNVQPLLYAACILQVELVARACCEYMKLHFHPSNCLAVRAFAESHNRTDLMDMADQYA 193

  Fly   203 CQYFMQVCQNQEFFQLNADQLGKLLSSDDLNVPSEQDVFHSLMSWVRHDSAAREQHIP----ELL 263
            |::|.:|.:.::|..::...|.|||||.|||:.||:.|:.:.:.|:    .|..||.|    |.|
  Rat   194 CEHFTEVVECEDFVSVSPQHLHKLLSSSDLNIDSEKQVYSAAIKWL----LANPQHHPKWLDETL 254

  Fly   264 ALVRLPLLQPAFIMDHV--ENVCNAN-ECQQLVMEAFKWHL------MPERRSRIATERTTPRKS 319
            |.||||||...|:|..|  |.:...| :|:.|:.||..:||      :|:....:   ||||||.
  Rat   255 AQVRLPLLPVDFLMGVVAKEQIVKQNLKCRDLLDEARNYHLHLSSKPVPDFEYSV---RTTPRKH 316

  Fly   320 TVGRLLAVGGMDAHKGAI-SIESYCPRLDKWTPWKHMTGRRLQFGAAVMEDKLILVGGRDGLKTL 383
            |.|.|..|||........ |||.|....:.|.....|..||...|...:|.|:..|||.||.:.|
  Rat   317 TAGVLFCVGGRGGSGDPFRSIECYSINTNSWFFGPEMNSRRRHVGVISVEGKVYAVGGHDGNEHL 381

  Fly   384 NTVESLDLNTMAWAPLNAMATPRHGLGVAVLEGPLYAVGGHDGWSYLNTVERWDPIARTWSYVAP 448
            .::|..|..|..|....:|.|.|.|:.:|.|.||:||:||.|..:..:.|||:|..:..||.|||
  Rat   382 GSMEMFDPLTNKWMVKASMNTKRRGIALASLGGPIYAIGGLDDNTCFSDVERYDIESDQWSTVAP 446

  Fly   449 MSSMRSTAGVAVLGGRLYAVGGRDGSVCHRSIECYDPHTNKWSLLAPMNRRRGGVGVTVANGFLY 513
            |::.|...|...|...:|||||.||.....|:|.|.||.:||..:..|.:||.|.||:..:|.||
  Rat   447 MNTPRGGVGSVALINHVYAVGGNDGVASLSSVERYHPHLDKWVEVKEMGQRRAGNGVSELHGCLY 511

  Fly   514 ALGGHDCPASNPMVCRTETVERYDPATDTWTLICSLALGRDAIGCALLGDRLIVVGGYDGNHALK 578
            .:||.|  .::|:    .:||||||.::.|..:.:|...|..:|.|.:..::..|||::||..|.
  Rat   512 VVGGFD--DNSPL----SSVERYDPRSNKWDYVAALTTPRGGVGIATVMGKIFAVGGHNGNAYLN 570

  Fly   579 SVEEYDPVRNGWNELAPMAFARAGACV 605
            :||.:|||.|.|..:.|::..||||.|
  Rat   571 TVEAFDPVLNKWELVGPVSHCRAGAGV 597

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17754	NP_572549.2	BTB	70..170	CDD:279045	35/99 (35%)
		PHA03098	71..591	CDD:222983	199/533 (37%)
		BACK	179..281	CDD:285009	42/107 (39%)
		Kelch	323..369	CDD:128874	13/46 (28%)
		KELCH repeat	359..402	CDD:276965	14/42 (33%)
		Kelch	370..416	CDD:128874	17/45 (38%)
		KELCH repeat	406..449	CDD:276965	19/42 (45%)
		Kelch	418..463	CDD:128874	18/44 (41%)
		KELCH repeat	453..497	CDD:276965	17/43 (40%)
		Kelch	464..510	CDD:128874	20/45 (44%)
		Kelch_1	499..546	CDD:279660	19/46 (41%)
		KELCH repeat	500..549	CDD:276965	18/48 (38%)
		KELCH repeat	553..596	CDD:276965	16/42 (38%)
		Kelch	564..610	CDD:128874	19/42 (45%)
Klhl8	NP_001099465.1	BTB	58..162	CDD:279045	35/105 (33%)
		PHA03098	61..536	CDD:222983	182/489 (37%)
		BACK	170..272	CDD:285009	41/105 (39%)
		Kelch	320..367	CDD:128874	13/46 (28%)
		KELCH repeat	357..400	CDD:276965	14/42 (33%)
		Kelch	368..414	CDD:128874	17/45 (38%)
		KELCH repeat	404..448	CDD:276965	20/43 (47%)
		Kelch	416..459	CDD:128874	17/42 (40%)
		KELCH repeat	451..496	CDD:276965	18/44 (41%)
		Kelch	462..508	CDD:128874	20/45 (44%)
		KELCH repeat	498..543	CDD:276965	19/50 (38%)
		Kelch	509..555	CDD:128874	17/51 (33%)
		KELCH repeat	545..587	CDD:276965	16/41 (39%)
		Kelch	556..601	CDD:128874	19/42 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4441
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D312716at33208
OrthoFinder	1	1.000	-	-		FOG0000036
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820