Protein Alignment CG17754 and KLHL35

DIOPT Version :10

• Sequence 1: NP_572549.2
• Gene: CG17754 / 31873
• FlyBaseID: FBgn0030114
• Length: 654
• Species: Drosophila melanogaster
• Sequence 2: NP_001034637.2
• Gene: KLHL35 / 283212
• HGNCID: 26597
• Length: 583
• Species: Homo sapiens
• Alignment Length: 593
• Identity: 176/593 - (29%)
• Similarity: 281/593 - (47%)
• Gaps: 72/593 - (12%)

  Fly    57 HADNILKRMQLYVDSQQLCDVVLIAGIDGKRVPAHRLVLSASSAYFSAMFTGSLRETKEQEVTLG 121
            ||..:|:.:..|..|..|.||||.||  |:..|.||..|||.||||.::|.....|.....|.:.
Human    23 HAQRVLQALNAYRRSGTLTDVVLRAG--GRDFPCHRAALSAGSAYFRSLFAAGRPERGPAVVPVV 85

  Fly   122 EVHGD-----------ALHLLVQYCYTGFIEMR-EDTVETLLATACLLQLNAVVTACCNFLARQL 174
            .|..:           ||.:::.|.|...:.:| ||....:||.|..|.:..:..||..||..:|
Human    86 PVAPEAPGTSPAGAAAALAVVLDYVYGAGVRLRAEDEAAAVLALAERLGVAGLREACVRFLEGRL 150

  Fly   175 HPSNCL-------GFAFFAEQQSCTTLLRLAQAYTCQYFMQVCQNQEFFQLNADQLGKLLSSDDL 232
            ..:|.|       .|:.....:.|..:||       |.|.:|.::.:|.:|..|::..||:...|
Human   151 RAANSLALRRVAAAFSLAPLAERCGRVLR-------QAFAEVARHADFLELAPDEVVALLADPAL 208

  Fly   233 NVPSEQDVFHSLMSWVRHDSAAREQHIPELLALVRLPLLQPAFIMDHVE-----NVCNANECQQL 292
            .|..|:.||.:.|.|||||:.||...:..||..||||||.||:.::.||     ..|  .||:.|
Human   209 GVAREEAVFEAAMRWVRHDAPARRGQLRRLLEHVRLPLLAPAYFLEKVEADELLQAC--GECRPL 271

  Fly   293 VMEAFKWHLMPERRSRIATERTTPRK--STVGRLLAVGGMDAHKGAISI---ESYCPRLDKWTPW 352
            ::||....::......:   ||.||:  .....::.:||.| .||.:.:   ::|.|...:|||.
Human   272 LLEARACFILGREAGAL---RTRPRRFMDLAEVIVVIGGCD-RKGLLKLPFADAYHPESQRWTPL 332

  Fly   353 KHMTG-RRLQFGAAVMEDKLILVGGRDGLKTLNTVE----SLDLNTMAWAPLNAMATPRHGLGVA 412
            ..:.| .|.:|.|..:.:.:.:.||.     :|:.:    |..|:|  |..:.::...|....:|
Human   333 PSLPGYTRSEFAACALRNDVYVSGGH-----INSHDVWMFSSHLHT--WIKVASLHKGRWRHKMA 390

  Fly   413 VLEGPLYAVGGHDGWSYLNTVERWDPIARTWSYVAPMSSMRSTAGVAVLGGRLYAVGG-RDGSVC 476
            |::|.|:||||.||...|::|||:||.:.||:..||:....|:|.||...|:|:.:|| |.|.|.
Human   391 VVQGQLFAVGGFDGLRRLHSVERYDPFSNTWAAAAPLPEAVSSAAVASCAGKLFVIGGARQGGVN 455

  Fly   477 HRSIECYDPHTNKWSLLAPMNRRRGGVGVTVANGFLYALGGHDCPASNPMVCRTETVERYDPATD 541
            ...::|:||..::|||.:|....:..:........:|.:||        ::.:..|   |||.||
Human   456 TDKVQCFDPKEDRWSLRSPAPFSQRCLEAVSLEDTIYVMGG--------LMSKIFT---YDPGTD 509

  Fly   542 TWTLICSLALGRDAIGCALLGDRLIVVGGYDG-NHALKSVEEYDPVRNGWNELAP--MAFARAGA 603
            .|.....|....::.|..:...::.::||.|. ..:...|..:|| .:|..|:.|  .....:..
Human   510 VWGEAAVLPSPVESCGVTVCDGKVHILGGRDDRGESTDKVFTFDP-SSGQVEVQPSLQRCTSSHG 573

  Fly   604 CVVAIPNV 611
            ||..|.::
Human   574 CVTIIQSL 581

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG17754	NP_572549.2	PHA03098	71..591	CDD:222983	167/555 (30%)
		KELCH repeat	359..402	CDD:276965	10/46 (22%)
		KELCH repeat	406..449	CDD:276965	20/42 (48%)
		KELCH repeat	453..497	CDD:276965	18/44 (41%)
		KELCH repeat	500..549	CDD:276965	10/48 (21%)
		KELCH repeat	553..596	CDD:276965	10/45 (22%)
KLHL35	NP_001034637.2	BTB_POZ_KLHL35	18..157	CDD:349574	44/135 (33%)
		BACK	156..255	CDD:197943	36/105 (34%)
		Kelch 1	301..350		14/49 (29%)
		NanM	302..553	CDD:442289	76/269 (28%)
		KELCH repeat	340..380	CDD:276965	10/46 (22%)
		Kelch 2	352..394		10/48 (21%)
		KELCH repeat	384..428	CDD:276965	21/43 (49%)
		Kelch 3	395..441		21/45 (47%)
		KELCH repeat	431..476	CDD:276965	18/44 (41%)
		Kelch 4	443..489		13/45 (29%)
		KELCH repeat	479..519	CDD:276965	11/50 (22%)
		Kelch 5	490..531		12/51 (24%)
		KELCH repeat	521..566	CDD:276965	10/45 (22%)
		Kelch	532..577	CDD:128874	11/45 (24%)
		Kelch 6	533..579		11/46 (24%)