DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG17754 and Klhl12

DIOPT Version :9

Sequence 1:	NP_572549.2	Gene:	CG17754 / 31873	FlyBaseID:	FBgn0030114	Length:	654	Species:	Drosophila melanogaster
Sequence 2:	XP_038946329.1	Gene:	Klhl12 / 266772	RGDID:	628717	Length:	592	Species:	Rattus norvegicus

Alignment Length:	571	Identity:	212/571 - (37%)
Similarity:	310/571 - (54%)	Gaps:	34/571 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 HADNILKRMQLYVDSQQLCDVVLIAGIDGKRVPAHRLVLSASSAYFSAMFTGS-------LRETK 114
            ||.:||..|.....|..||||.|  .::.|..||||:||:|.|.||.||||..       |.|..
  Rat    32 HAKSILNSMNSLRKSNTLCDVTL--RVEQKDFPAHRIVLAACSDYFCAMFTSEVNASLCYLSEKG 94

  Fly   115 EQEVTLGEVHGDALHLLVQYCYTGFIEMREDTVETLLATACLLQLNAVVTACCNFLARQLHPSNC 179
            :..|.:..:....:.:|:.:.||..:.:..:.|:.||..||||||..|..|||.||..||.||||
  Rat    95 KPYVDIQGLTASTMEILLDFVYTETVHVTVENVQELLPAACLLQLKGVKQACCEFLESQLDPSNC 159

  Fly   180 LGFAFFAEQQSCTTLLRLAQAYTCQYFMQVCQNQEFFQLNADQLGKLLSSDDLNVPSEQDVFHSL 244
            ||...|||..:|..|::.|:.::.::|.:|.|::||..|:..::.||:..|::.|.||:.||.::
  Rat   160 LGIRDFAETHNCVDLMQAAEVFSQKHFPEVVQHEEFILLSQGEVEKLIKCDEIQVDSEEPVFEAV 224

  Fly   245 MSWVRHDSAAREQHIPELLALVRLPLLQPAFIMDHVENV----CNANECQQLVMEAFKWHLMPER 305
            ::||:|....||:.:|:||..||:|||.|.:|.|.::..    |:. :|:.||.||.|:||.||.
  Rat   225 INWVKHAKKEREESLPDLLQYVRMPLLTPRYITDVIDAEPFIRCSL-QCRDLVDEAKKFHLRPEL 288

  Fly   306 RSRIATERTTPRKSTVGRLLAVGGMDAHKGAIS-IESYCPRLDKWTPWKHMTGRRLQFGAAVMED 369
            ||::...||..|......||.|||..:.:..|. :|.|.|:..:|:....:|.:|....:..:.|
  Rat   289 RSQMQGPRTRARLGANEVLLVVGGFGSQQSPIDVVEKYDPKTQEWSFLPSITRKRRYVASVSLHD 353

  Fly   370 KLILVGGRDGLKTLNTVESLDLNT---MAW---APLNAMATPRHGL-GVAVLEGPLYAVGGHDGW 427
            ::.::||.||...|::||.||...   ..|   ||:|.    |.|| |...|...:|..||.||.
  Rat   354 RIYVIGGYDGRSRLSSVECLDYTADEDGVWYSVAPMNV----RRGLAGATTLGDMIYVSGGFDGS 414

  Fly   428 SYLNTVERWDPIARTWSYVAPMSSMRSTAGVAVLGGRLYAVGGRDGSVCHRSIECYDPHTNKWSL 492
            ....::||:||....||.:..|.:.|..||:.|..|.:|.:||.||.....|:|.|||||..|:.
  Rat   415 RRHTSMERYDPNIDQWSMLGDMQTAREGAGLVVASGIIYCLGGYDGLNILNSVEKYDPHTGHWTN 479

  Fly   493 LAPMNRRRGGVGVTVANGFLYALGGHDCPASNPMVCRTETVERYDPATDTWTLICSLALGRDAIG 557
            :.||..:|.|.||.:.|..:|.:||.|..|      ...:||.|:..||:||.:.|:...|..:|
  Rat   480 VTPMATKRSGAGVALLNDHIYVVGGFDGTA------HLSSVEAYNIRTDSWTTVTSMTTPRCYVG 538

  Fly   558 CALLGDRLIVVGGYDGNHALKSVEEYDPVRNGWNELAPMAFAR--AGACVV 606
            ..:|..||..:.|||||..|.|:|.|||:.:.|..:|.|...|  ||.||:
  Rat   539 ATVLRGRLYAIAGYDGNSLLSSIECYDPIIDSWEVVASMGTQRCDAGVCVL 589

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17754	NP_572549.2	BTB	70..170	CDD:279045	40/106 (38%)
		PHA03098	71..591	CDD:222983	199/538 (37%)
		BACK	179..281	CDD:285009	39/101 (39%)
		Kelch	323..369	CDD:128874	12/46 (26%)
		KELCH repeat	359..402	CDD:276965	15/48 (31%)
		Kelch	370..416	CDD:128874	18/52 (35%)
		KELCH repeat	406..449	CDD:276965	16/43 (37%)
		Kelch	418..463	CDD:128874	16/44 (36%)
		KELCH repeat	453..497	CDD:276965	19/43 (44%)
		Kelch	464..510	CDD:128874	19/45 (42%)
		Kelch_1	499..546	CDD:279660	17/46 (37%)
		KELCH repeat	500..549	CDD:276965	17/48 (35%)
		KELCH repeat	553..596	CDD:276965	18/42 (43%)
		Kelch	564..610	CDD:128874	21/45 (47%)
Klhl12	XP_038946329.1	BTB_POZ_KLHL12_C3IP1_DKIR	29..159	CDD:349551	51/128 (40%)
		PHA03098	63..574	CDD:222983	192/521 (37%)
		BACK_KLHL12	154..289	CDD:350527	54/135 (40%)
		KELCH repeat	298..339	CDD:276965	11/40 (28%)
		KELCH repeat	343..389	CDD:276965	13/45 (29%)
		KELCH repeat	393..436	CDD:276965	15/42 (36%)
		KELCH repeat	440..483	CDD:276965	18/42 (43%)
		KELCH repeat	487..531	CDD:276965	18/49 (37%)
		KELCH repeat	534..579	CDD:276965	19/44 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4441
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D312716at33208
OrthoFinder	1	1.000	-	-		FOG0000036
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.820