Protein Alignment CG17754 and KLHL18

DIOPT Version :10

• Sequence 1: NP_572549.2
• Gene: CG17754 / 31873
• FlyBaseID: FBgn0030114
• Length: 654
• Species: Drosophila melanogaster
• Sequence 2: XP_005265058.2
• Gene: KLHL18 / 23276
• HGNCID: 29120
• Length: 584
• Species: Homo sapiens
• Alignment Length: 553
• Identity: 206/553 - (37%)
• Similarity: 291/553 - (52%)
• Gaps: 24/553 - (4%)

  Fly    73 QLCDVVLIAGIDGKRVPAHRLVLSASSAYFSAMFTGSLRETKEQEVTLGEVHGDALHLLVQYCYT 137
            :||||.|..|  ..:..|||:||:||..||.||||..:.|.|:.|:.:..:...||..|:.:.|.
Human    36 KLCDVTLKIG--DHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYN 98

  Fly   138 GFIEMREDTVETLLATACLLQLNAVVTACCNFLARQLHPSNCLGFAFFAEQQSCTTLLRLAQAYT 202
            |.:.:.:..|::||..|..|||.::..|||.||..:|||.||||...|||...|..|...|.::.
Human    99 GNLAIDQQNVQSLLMGASFLQLQSIKDACCTFLRERLHPKNCLGVRQFAETMMCAVLYDAANSFI 163

  Fly   203 CQYFMQVCQNQEFFQLNADQLGKLLSSDDLNVPSEQDVFHSLMSWVRHDSAAREQHIPELLALVR 267
            .|:|::|..::||..|..:.:.:|:|.|:|||.||:.||.:.::|||:|...|..::||||:.:|
Human   164 HQHFVEVSMSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALAWVRYDREQRGPYLPELLSNIR 228

  Fly   268 LPLLQPAFIMDHVEN---VCNANECQQLVMEAFKWHLMPERRSRIATERTTPR--KSTVGRLLAV 327
            |||.:|.|:.|.|:.   |...::|:.||.||..:|||||||..:...||.||  .|..|.:.||
Human   229 LPLCRPQFLSDRVQQDDLVRCCHKCRDLVDEAKDYHLMPERRPHLPAFRTRPRCCTSIAGLIYAV 293

  Fly   328 GGMDAHKGAIS------IESYCPRLDKWTPWKHMTGRRLQFGAAVMEDKLILVGGRDGLKTLNTV 386
            ||:::.....:      :|.:.|..:.|...:.||..|.:.|.||:...|..:||.||...|:||
Human   294 GGLNSAANFYAGDSLNVVEVFDPIANCWERCRPMTTARSRVGVAVVNGLLYAIGGYDGQLRLSTV 358

  Fly   387 ESLDLNTMAWAPLNAMATPR-----HGLGVAVLEGPLYAVGGHDGWSYLNTVERWDPIARTWSYV 446
            |:.:..|..|..:.:|.:.|     ..:|..||:|.:|..||:||.|.|::||.:.|....|:.|
Human   359 EAYNPETDTWTRVGSMNSKRSSVCFSAMGTVVLDGQIYVCGGYDGNSSLSSVETYSPETDKWTVV 423

  Fly   447 APMSSMRSTAGVAVLGGRLYAVGGRDGSVCHRSIECYDPHTNKWSLLAPMNRRRGGVGVTVANGF 511
            ..|||.||.|||.|..||:|..||.||.....|:|.|:.||..|...|.|..:|...|.......
Human   424 TSMSSNRSAAGVTVFEGRIYVSGGHDGLQIFSSVEHYNHHTATWHPAAGMLNKRCRHGAASLGSK 488

  Fly   512 LYALGGHDCPASNPMVCRTETVERYDPATDTWTLICSLALGRDAIGCALLGDRLIVVGGYDGNHA 576
            ::..||:|....      ....|.|....|.|.||..:...|..:.......||..||||||...
Human   489 MFVCGGYDGSGF------LSIAEMYSSVADQWCLIVPMHTRRSRVSLVASCGRLYAVGGYDGQSN 547

  Fly   577 LKSVEEYDPVRNGWNELAPMAFARAGACVVAIP 609
            |.|||.|||..:.|..:||||....|..|..||
Human   548 LSSVEMYDPETDCWTFMAPMACHEGGVGVGCIP 580

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG17754	NP_572549.2	PHA03098	71..591	CDD:222983	197/533 (37%)
		KELCH repeat	359..402	CDD:276965	15/42 (36%)
		KELCH repeat	406..449	CDD:276965	17/47 (36%)
		KELCH repeat	453..497	CDD:276965	20/43 (47%)
		KELCH repeat	500..549	CDD:276965	11/48 (23%)
		KELCH repeat	553..596	CDD:276965	18/42 (43%)
KLHL18	XP_005265058.2	BTB_POZ_KLHL18	19..134	CDD:349556	39/99 (39%)
		PHA03098	34..562	CDD:222983	197/533 (37%)
		BACK_KLHL18	135..241	CDD:350532	45/105 (43%)
		KELCH repeat	282..327	CDD:276965	9/44 (20%)
		KELCH repeat	331..374	CDD:276965	15/42 (36%)
		KELCH repeat	378..427	CDD:276965	17/48 (35%)
		KELCH repeat	430..474	CDD:276965	20/43 (47%)
		KELCH repeat	477..521	CDD:276965	11/49 (22%)
		KELCH repeat	524..567	CDD:276965	18/42 (43%)