DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17754 and Klhl17

DIOPT Version :9

Sequence 1:	NP_572549.2	Gene:	CG17754 / 31873	FlyBaseID:	FBgn0030114	Length:	654	Species:	Drosophila melanogaster
Sequence 2:	NP_938047.1	Gene:	Klhl17 / 231003	MGIID:	2678948	Length:	640	Species:	Mus musculus

Alignment Length:	629	Identity:	246/629 - (39%)
Similarity:	345/629 - (54%)	Gaps:	40/629 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 QKESPSRDSTASTSGHISMLADNTLESLSRD-YSLGSLNSAGSQDEFFRCRDHADNILKRMQLYV 69
            |..:|..:.........:...:..::.|||: :|:...:.....|.|.        .:.||:
Mouse    31 QPPAPEAERARPRQARPAAPMEGAMQLLSREGHSVAHNSKRHYHDAFV--------AMSRMR--- 84

  Fly    70 DSQQLCDVVLIAGIDGKRVPAHRLVLSASSAYFSAMFTGSLRETKEQEVTLGEVHGDALHLLVQY 134
            ....|||:||  .:..|.:.||::||::.|.||.||||..:.|:::..|||.::...||..|||:
Mouse    85 QRGLLCDIVL--HVAAKEIRAHKVVLASCSPYFHAMFTNEMSESRQTHVTLHDIDPQALDQLVQF 147

  Fly   135 CYTGFIEMREDTVETLLATACLLQLNAVVTACCNFLARQLHPSNCLGFAFFAEQQSCTTLLRLAQ 199
            .||..|.:.|..|:|||..|.|||||.|..|||.||..||.||||||...||:..||:.||:.|.
Mouse   148 AYTAEIVVGEGNVQTLLPAASLLQLNGVRDACCKFLLSQLDPSNCLGIRGFADTHSCSDLLKAAH 212

  Fly   200 AYTCQYFMQVCQNQEFFQLNADQLGKLLSSDDLNVPSEQDVFHSLMSWVRHDSAAREQHIPELLA 264
            .|..|:|:.|.:.:||..|...|:.:|:|||.||||||:||:.:::|||:||...|.||:|.|:.
Mouse   213 RYVLQHFVDVAKTEEFMLLPLKQVLELVSSDSLNVPSEEDVYRAVLSWVKHDVDTRRQHVPRLMK 277

  Fly   265 LVRLPLLQPAFIMDHVEN---VCNANECQQLVMEAFKWHLMPERRSRIATERTTPRK-STVGRLL 325
            .||||||...|::.||:.   |.:..:|:.|::||.|:||:||:|..:.|.||.||: ...|.:|
Mouse   278 CVRLPLLSRDFLLGHVDAESLVRHHPDCKDLLIEALKFHLLPEQRGVLGTSRTRPRRCEGAGPVL 342

  Fly   326 -AVGGMDAHKGAI-----SIESYCPRLDKWTPWKHMTGRRLQFGAAVMEDKLILVGGRDGLKTLN 384
             ||||     |::     ..|:|..|.|:|.....|:.||.:.|.|.:.::|..|||.||...|.
Mouse   343 FAVGG-----GSLFAIHGDCEAYDTRTDRWHVVASMSTRRARVGVAAVGNRLYAVGGYDGTSDLA 402

  Fly   385 TVESLDLNTMAWAPLNAMATPRHGLGVAVLEGPLYAVGGHDGWSYLNTVERWDPIARTWSYVAPM 449
            ||||.|..|..|.|..:|.|.|..||||.|.|.|||.||:||.|.||:.||:||:..||:.:|.|
Mouse   403 TVESYDPVTNTWQPEVSMGTRRSCLGVAALHGLLYAAGGYDGASCLNSAERYDPLTGTWTSIAAM 467

  Fly   450 SSMRSTAGVAVLGGRLYAVGGRDGSVCHRSIECYDPHTNKWSLLAPMNRRRGGVGVTVANGFLYA 514
            |:.|....||.|.|.||||||.|.|....::|.|:|..|.|:.:|.|..||...||.|..|.||.
Mouse   468 STRRRYVRVATLDGNLYAVGGYDSSSHLATVEKYEPQVNSWTPVASMLSRRSSAGVAVLEGALYV 532

  Fly   515 LGGHDCPASNPMVCRTETVERYDPATDTWTLICSLALGRDAIGCALLGDRLIVVGGYDGNHALKS 579
            .||:|..:     | ..:||||......|..:..:.:.|.......:...|..|||.||:.:|.|
Mouse   533 AGGNDGTS-----C-LNSVERYSTKAGAWESVAPMNIRRSTHDLVAMDGWLYAVGGNDGSSSLNS 591

  Fly   580 VEEYDPVRNGWNELAPMAFARAGACVVAIPNVIPPAAQQPPPSA 623
            :|:|:|..|.| ..|...|.|..:..||:..::    ..||||:
Mouse   592 IEKYNPRTNKW-VAASCMFTRRSSVGVAVLELL----NFPPPSS 630

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17754	NP_572549.2	BTB	70..170	CDD:279045	44/99 (44%)
		PHA03098	71..591	CDD:222983	226/529 (43%)
		BACK	179..281	CDD:285009	48/101 (48%)
		Kelch	323..369	CDD:128874	16/51 (31%)
		KELCH repeat	359..402	CDD:276965	18/42 (43%)
		Kelch	370..416	CDD:128874	23/45 (51%)
		KELCH repeat	406..449	CDD:276965	24/42 (57%)
		Kelch	418..463	CDD:128874	23/44 (52%)
		KELCH repeat	453..497	CDD:276965	19/43 (44%)
		Kelch	464..510	CDD:128874	20/45 (44%)
		Kelch_1	499..546	CDD:279660	17/46 (37%)
		KELCH repeat	500..549	CDD:276965	16/48 (33%)
		KELCH repeat	553..596	CDD:276965	15/42 (36%)
		Kelch	564..610	CDD:128874	18/45 (40%)
Klhl17	NP_938047.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..50		2/18 (11%)
		BTB_POZ_KLHL17_actinfilin	51..189	CDD:349555	56/150 (37%)
		PHA03098	90..556	CDD:222983	211/478 (44%)
		BACK	187..288	CDD:421692	50/100 (50%)
		Interaction with F-actin. /evidence=ECO:0000250	287..639		139/360 (39%)
		KELCH repeat	377..420	CDD:276965	18/42 (43%)
		KELCH repeat	424..468	CDD:276965	24/43 (56%)
		KELCH repeat	471..516	CDD:276965	20/44 (45%)
		KELCH repeat	518..562	CDD:276965	16/49 (33%)
		KELCH repeat	565..610	CDD:276965	15/45 (33%)
		Kelch	577..621	CDD:128874	18/44 (41%)
		Interaction with PDZK1. /evidence=ECO:0000250	638..640
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4441
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D312716at33208
OrthoFinder	1	1.000	-	-		FOG0000036
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.820