Protein Alignment CG17754 and Klhl20

DIOPT Version :10

• Sequence 1: NP_572549.2
• Gene: CG17754 / 31873
• FlyBaseID: FBgn0030114
• Length: 654
• Species: Drosophila melanogaster
• Sequence 2: NP_001034571.1
• Gene: Klhl20 / 226541
• MGIID: 2444855
• Length: 604
• Species: Mus musculus
• Alignment Length: 561
• Identity: 236/561 - (42%)
• Similarity: 330/561 - (58%)
• Gaps: 20/561 - (3%)

  Fly    57 HADNILKRMQLYVDSQQLCDVVLIAGIDGKRVPAHRLVLSASSAYFSAMFTGSLRETKEQEVTLG 121
            |....|:.:.|....::||||||:.|  .|::.|||::|||.|.||.|||||.|.|:::.||.:.
Mouse    45 HPRQTLEVINLLRKHRELCDVVLVVG--AKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIR 107

  Fly   122 EVHGDALHLLVQYCYTGFIEMREDTVETLLATACLLQLNAVVTACCNFLARQLHPSNCLGFAFFA 186
            ::...|:.||:.:.||..|.:.|..|:|||..||||||..:..|||.||.|||.||||||...||
Mouse   108 DIDERAMELLIDFAYTSQITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQLDPSNCLGIRAFA 172

  Fly   187 EQQSCTTLLRLAQAYTCQYFMQVCQNQEFFQLNADQLGKLLSSDDLNVPSEQDVFHSLMSWVRHD 251
            :..||..|||:|..:|...|.:|.:::||..|.|:||..::|||:|||.||:.||:::|:||::.
Mouse   173 DTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYS 237

  Fly   252 SAAREQHIPELLALVRLPLLQPAFIMDHVEN---VCNANECQQLVMEAFKWHLMPERRSRIATER 313
            ...|...:|::|..||||||.|.|::..|.:   :.:..||:.||.||..:.|:|:.|..:...|
Mouse   238 IQERRPQLPQVLQHVRLPLLSPKFLVGTVGSDPLIKSDEECRDLVDEAKNYLLLPQERPLMQGPR 302

  Fly   314 TTPRKS-TVGRLL-AVGGMDAHKGAISIESYCPRLDKWTPWKHMTGRRLQFGAAVMEDKLILVGG 376
            |.|||. ..|.:| ||||..:.....|:|.|.|:.::|.....|:.||...|.:|::|.|..|||
Mouse   303 TRPRKPIRCGEVLFAVGGWCSGDAISSVERYDPQTNEWRMVASMSKRRCGVGVSVLDDLLYAVGG 367

  Fly   377 RDGLKTLNTVESLDLNTMAW----APLNAMATPRHGLGVAVLEGPLYAVGGHDGWSYLNTVERWD 437
            .||...||:||..|..|..|    ||   .:|.|..:|||||.|.||||||.||.|.||.|||:|
Mouse   368 HDGSSYLNSVERYDPKTNQWSSDVAP---TSTCRTSVGVAVLGGFLYAVGGQDGVSCLNIVERYD 429

  Fly   438 PIARTWSYVAPMSSMRSTAGVAVLGGRLYAVGGRDGSVCHRSIECYDPHTNKWSLLAPMNRRRGG 502
            |....|:.||.||:.|....||||||.||||||.||:....::|.|:|..|:|..:|||..||..
Mouse   430 PKENKWTRVASMSTRRLGVAVAVLGGFLYAVGGSDGTSPLNTVERYNPQENRWHTIAPMGTRRKH 494

  Fly   503 VGVTVANGFLYALGGHDCPASNPMVCRTETVERYDPATDTWTLICSLALGRDAIGCALLGDRLIV 567
            :|..|....:||:||.|      ......:.|||:|.|:.|:.:.::...|..:|.|::..:|:.
Mouse   495 LGCAVYQDMIYAVGGRD------DTTELSSAERYNPRTNQWSPVVAMTSRRSGVGLAVVNGQLMA 553

  Fly   568 VGGYDGNHALKSVEEYDPVRNGWNELAPMAFARAGACVVAI 608
            |||:||...||::|.:||..|.|.....|.:.|.|..|..|
Mouse   554 VGGFDGTTYLKTIEVFDPDANTWRLYGGMNYRRLGGGVGVI 594

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG17754	NP_572549.2	PHA03098	71..591	CDD:222983	227/528 (43%)
		KELCH repeat	359..402	CDD:276965	19/46 (41%)
		KELCH repeat	406..449	CDD:276965	26/42 (62%)
		KELCH repeat	453..497	CDD:276965	22/43 (51%)
		KELCH repeat	500..549	CDD:276965	14/48 (29%)
		KELCH repeat	553..596	CDD:276965	16/42 (38%)
Klhl20	NP_001034571.1	BTB_POZ_KLHL20_KLEIP	40..167	CDD:349558	58/123 (47%)
		PHA03098	58..581	CDD:222983	228/533 (43%)
		Kelch 1	314..360		15/45 (33%)
		KELCH repeat	350..394	CDD:276965	19/46 (41%)
		Kelch 2	362..408		22/48 (46%)
		KELCH repeat	398..442	CDD:276965	26/43 (60%)
		Kelch 3	409..455		26/45 (58%)
		KELCH repeat	445..490	CDD:276965	23/44 (52%)
		Kelch 4	457..502		20/44 (45%)
		KELCH repeat	492..535	CDD:276965	14/48 (29%)
		Kelch 5	504..549		14/50 (28%)
		KELCH repeat	539..584	CDD:276965	17/44 (39%)
		Kelch 6	551..596		18/44 (41%)