DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17754 and Ipp

DIOPT Version :9

Sequence 1:	NP_572549.2	Gene:	CG17754 / 31873	FlyBaseID:	FBgn0030114	Length:	654	Species:	Drosophila melanogaster
Sequence 2:	NP_032415.2	Gene:	Ipp / 16351	MGIID:	96581	Length:	584	Species:	Mus musculus

Alignment Length:	581	Identity:	195/581 - (33%)
Similarity:	279/581 - (48%)	Gaps:	28/581 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 DEFFRCRDHADNILKRMQLYVDSQQLCDVVLIAGIDGKRVPAHRLVLSASSAYFSAMFTGSLRET 113
            |..|....||..||.:|......|..|||.|..|.:..:|  |||||:|||.||:|:|||.::|:
Mouse    11 DNSFSSDKHAQLILAQMNKMRSGQHFCDVQLQVGKETFQV--HRLVLAASSPYFAALFTGGMKES 73

  Fly   114 KEQEVTLGEVHGDALHLLVQYCYTGFIEMREDTVETLLATACLLQLNAVVTACCNFLARQLHPSN 178
            .:..|.:..|......||:.:.|||.:.:....|:.|:..|.:|||..||..||:||..|:.|.|
Mouse    74 SKDVVQILGVEAGIFQLLLDFIYTGVVNIAVTNVQELIVAADMLQLTEVVNLCCDFLKGQIDPQN 138

  Fly   179 CLGFAFFAEQQSCTTLLRLAQAYTCQYFMQVCQNQEFFQLNADQLGKLLSSDDLNVPSEQDVFHS 243
            |:|...|:||.:|..||...:.|...:|::|...:||..|..|||.|:|.|::|::..|..||.:
Mouse   139 CIGLFQFSEQIACHDLLEFTENYIHVHFLEVHTGEEFLGLTKDQLIKILRSEELSIEDEYQVFLA 203

  Fly   244 LMSWVRHDSAAREQHIPELLALVRLPLLQPAFIMDHVENVCNAN---ECQQLVMEAFKWHLMPER 305
            .|.|:..|...|.:|:.|:|..||.|||....::.::|.|.:.|   ..|.|:.|..:....|:.
Mouse   204 AMQWILKDLGKRRKHVVEVLDPVRFPLLPSQRLLKYIEGVSDFNLRVALQTLLKEYCEVCKSPKE 268

  Fly   306 R---SRIATERTTPRKSTVGRLLAVGGMDAHKG-------AIS-IESYCPRLDKWTPWKHMTGRR 359
            .   |.:.|.:..|||.....|.||||....:|       |:| :|.:......||....:...|
Mouse   269 NKFCSFLQTSKVRPRKKARKYLYAVGGYTRLQGGRWSDSRALSCVERFDTFSQYWTTVSSLHQAR 333

  Fly   360 LQFGAAVMEDKLILVGGRDGLKTLNTVESLDLNTMAWAPLNAMATPRHGLGVAVLEGPLYAVGGH 424
            ...|.||:...:..:||.......:..|..|..|..|..:.:|..||.||||.|..|.:||:||.
Mouse   334 CGLGVAVVGGMVYAIGGEKDSMIFDCTECYDPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGW 398

  Fly   425 DGWSYLNTVERWDPIARTWSYVAPMSSMRSTAGVAVLGGRLYAVGGRDGSVCH-RSIECYDPHTN 488
            .|....||:||:||....|..|..|:..|...|...:.|.:|||||....... ||.|.|||.:.
Mouse   399 VGAEIGNTIERFDPDENKWEVVGSMAVSRYYFGCCEMQGLIYAVGGISNEGLELRSFEVYDPLSK 463

  Fly   489 KWSLLAPMNRRRGGVGVTVANGFLYALGGHDCPASNPMVCRTETVERYDPATDTWTLICSLALGR 553
            :||.|.||..||..:||...|..:||:||.     |.......|||:|....:.|..:.|:.:.|
Mouse   464 RWSPLPPMGTRRAYLGVAALNDCIYAIGGW-----NETQDALHTVEKYSFEEEKWVEVASMKVPR 523

  Fly   554 DAIGCALLGDRLIVVGGYDGNH------ALKSVEEYDPVRNGWNELAPMAFARAGACVVAI 608
            ..:....:...|.|.||...:|      .|.|||.|:|..:.|.|:..|..:|....|..:
Mouse   524 AGMCAVTVNGLLYVSGGRSSSHDFLAPGTLDSVEVYNPHSDTWTEIGNMITSRCEGGVAVL 584

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17754	NP_572549.2	BTB	70..170	CDD:279045	39/99 (39%)
		PHA03098	71..591	CDD:222983	183/540 (34%)
		BACK	179..281	CDD:285009	36/101 (36%)
		Kelch	323..369	CDD:128874	15/53 (28%)
		KELCH repeat	359..402	CDD:276965	10/42 (24%)
		Kelch	370..416	CDD:128874	14/45 (31%)
		KELCH repeat	406..449	CDD:276965	20/42 (48%)
		Kelch	418..463	CDD:128874	16/44 (36%)
		KELCH repeat	453..497	CDD:276965	18/44 (41%)
		Kelch	464..510	CDD:128874	20/46 (43%)
		Kelch_1	499..546	CDD:279660	15/46 (33%)
		KELCH repeat	500..549	CDD:276965	14/48 (29%)
		KELCH repeat	553..596	CDD:276965	14/48 (29%)
		Kelch	564..610	CDD:128874	16/51 (31%)
Ipp	NP_032415.2	BTB	27..131	CDD:279045	41/105 (39%)
		PHA03098	34..575	CDD:222983	186/547 (34%)
		BACK	139..241	CDD:285009	36/101 (36%)
		Kelch	290..343	CDD:128874	15/52 (29%)
		Kelch 1	296..343		10/46 (22%)
		KELCH repeat	333..376	CDD:276965	10/42 (24%)
		Kelch 2	344..390		14/45 (31%)
		Kelch	345..390	CDD:128874	14/44 (32%)
		KELCH repeat	380..424	CDD:276965	20/43 (47%)
		Kelch 3	391..437		16/45 (36%)
		Kelch	392..437	CDD:128874	16/44 (36%)
		KELCH repeat	427..473	CDD:276965	19/45 (42%)
		Kelch	438..485	CDD:128874	20/46 (43%)
		Kelch 4	439..485		20/45 (44%)
		KELCH repeat	475..520	CDD:276965	15/49 (31%)
		Kelch	486..533	CDD:128874	12/51 (24%)
		Kelch 5	487..533		12/50 (24%)
		KELCH repeat	523..574	CDD:276965	15/50 (30%)
		Kelch	534..584	CDD:128874	16/49 (33%)
		Kelch 6	535..583		16/47 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4441
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D312716at33208
OrthoFinder	1	1.000	-	-		FOG0000036
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.820