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Protein Alignment CG17754 and KLHL2

DIOPT Version :9

Sequence 1:	NP_572549.2	Gene:	CG17754 / 31873	FlyBaseID:	FBgn0030114	Length:	654	Species:	Drosophila melanogaster
Sequence 2:	XP_011529874.1	Gene:	KLHL2 / 11275	HGNCID:	6353	Length:	633	Species:	Homo sapiens

Alignment Length:	566	Identity:	222/566 - (39%)
Similarity:	322/566 - (56%)	Gaps:	34/566 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 DHADNILKRMQLYVDSQQLCDVVLIAGIDGKRVPAHRLVLSASSAYFSAMFTGSLRETKEQEVTL 120
            |::.|:            ||||.::|  :...:.|||:||:|.|.||.|||||.:.|::.:.|.:
Human    89 DYSQNL------------LCDVTIVA--EDMEISAHRVVLAACSPYFHAMFTGEMSESRAKRVRI 139

  Fly   121 GEVHGDALHLLVQYCYTGFIEMREDTVETLLATACLLQLNAVVTACCNFLARQLHPSNCLGFAFF 185
            .||.|..|.:|:.|.||..|::.|:.|:.||..|.||||..|...||.||..||||.||||...|
Human   140 KEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVNCLGIRAF 204

  Fly   186 AEQQSCTTLLRLAQAYTCQYFMQVCQNQEFFQLNADQLGKLLSSDDLNVPSEQDVFHSLMSWVRH 250
            |:..:||.||..|..|..|:|..|..::||..|..:|:..|:|||.|.:.||:.||.::::||.|
Human   205 ADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNH 269

  Fly   251 DSAAREQHIPELLALVRLPLLQPAFIMDHVEN---VCNANECQQLVMEAFKWHLMP-ERRSRIAT 311
            |...|::.:..|:..||||||...:::..||.   |.|::.|:..::||.|:||:| |:|..:.:
Human   270 DKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYLIEAMKYHLLPTEQRILMKS 334

  Fly   312 ERT---TPRKSTVGRLLAVGGMDAHKGAISIESYCPRLDKWTPWKHMTGRRLQFGAAVMEDKLIL 373
            .||   ||  ..:.:|:.|.|..|.|...|:|.|..:.::|.....:..||.:.|...|...:..
Human   335 VRTRLRTP--MNLPKLMVVVGGQAPKAIRSVECYDFKEERWHQVAELPSRRCRAGMVYMAGLVFA 397

  Fly   374 VGGRDGLKTLNTVESLDLNTMAWAPLNAMATPRHGLGVAVLEGPLYAVGGHDGWSYLNTVERWDP 438
            |||.:|...:.||:|.|.....|..:..|...|..||.|||.|.||||||.||.:.|::||.::.
Human   398 VGGFNGSLRVRTVDSYDPVKDQWTSVANMRDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNI 462

  Fly   439 IARTWSYVAPMSSMRSTAGVAVLGGRLYAVGGRDGS--VCHRSIECYDPHTNKWSLLAPMNRRRG 501
            .:..|.:||||::.||:.||.|:||.||||||.||:  .|..::|||:..||:|:.:|.|:.||.
Human   463 KSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRS 527

  Fly   502 GVGVTVANGFLYALGGHDCPASNPMVCRTETVERYDPATDTWTLICSLALGRDAIGCALLGDRLI 566
            |.||.|.|..|||:||||    .|:|  .::||.|||.|:.|..:..:.:.|...|...:...|.
Human   528 GAGVGVLNNLLYAVGGHD----GPLV--RKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLY 586

  Fly   567 VVGGYDGNHALKSVEEYDPVRNGWNELAP-MAFAR--AGACVVAIP 609
            ||||.||:..|.|||.|:|..:.|..::. |:..|  ||..|:..|
Human   587 VVGGDDGSCNLASVEYYNPTTDKWTVVSSCMSTGRSYAGVTVIDKP 632

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.