DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17754 and IVNS1ABP

DIOPT Version :9

Sequence 1:	NP_572549.2	Gene:	CG17754 / 31873	FlyBaseID:	FBgn0030114	Length:	654	Species:	Drosophila melanogaster
Sequence 2:	XP_011507381.1	Gene:	IVNS1ABP / 10625	HGNCID:	16951	Length:	649	Species:	Homo sapiens

Alignment Length:	675	Identity:	167/675 - (24%)
Similarity:	287/675 - (42%)	Gaps:	139/675 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 SGHISMLADNTLESLSRDYSLGSLNSAGSQDEFFRCRDHADNILKRMQLYVDSQQLCDVVLIAGI 83
            :|::....:|.:||     |:..||:                 |::      |.|.|||.|  .:
Human     4 NGYLMFEDENFIES-----SVAKLNA-----------------LRK------SGQFCDVRL--QV 38

  Fly    84 DGKRVPAHRLVLSASSAYFSAMFTGSLRETKEQEVTLGEVHGDALHLLVQYCYTGFIEMREDTVE 148
            .|..:.|||.||:..|.|...:|...........|...:::.:|:.:|:.|.||..::..::.|:
Human    39 CGHEMLAHRAVLACCSPYLFEIFNSDSDPHGISHVKFDDLNPEAVEVLLNYAYTAQLKADKELVK 103

  Fly   149 TLLATACLLQLNAVVTACCNFLARQLHPSNCLGFAFFAEQQSCTTLLRLAQAYTCQYFMQVCQNQ 213
            .:.:.|..|:::.|...|.::|..::..::|:.:..||.....:.||....||..::.:|:.:.:
Human   104 DVYSAAKKLKMDRVKQVCGDYLLSRMDVTSCISYRNFASCMGDSRLLNKVDAYIQEHLLQISEEE 168

  Fly   214 EFFQLNADQLGKLLSSDDLNVPSEQDVFHSLMSWVRHDSAAREQHIPELLALVRL-------PLL 271
            ||.:|...:| :::..|::.:||...::..:::||:.........:.||:..|:.       .||
Human   169 EFLKLPRLKL-EVMLEDNVCLPSNGKLYTKVINWVQRSIWENGDSLEELMEEVQTLYYSADHKLL 232

  Fly   272 QPAFI----------MDHVENV--------------------------CNANECQQLVMEAFKWH 300
            ....:          .||::.|                          |.::....:.....:|.
Human   233 DGNLLDGQAEVFGSDDDHIQFVQVHIAQSEKKPPRENGHKQISSSSTGCLSSPNATVQSPKHEWK 297

  Fly   301 LMPE-------------------------RRSRIATERTTPRKSTV------------------- 321
            ::..                         |.|..::..:||:.|..
Human   298 IVASEKTSNNTYLCLAVLDGIFCVIFLHGRNSPQSSPTSTPKLSKSLSFEMQQDELIEKPMSPMQ 362

  Fly   322 ------------GRLLAVGGMDAHKGAISIESYCPRLDKWTPWKHMTGRRLQFGAAVMEDKLILV 374
                        |:|:|.||.:..:...::|.|.|..|.|:....|...|.:|..||:..:|.:|
Human   363 YARSGLGTAEMNGKLIAAGGYNREECLRTVECYNPHTDHWSFLAPMRTPRARFQMAVLMGQLYVV 427

  Fly   375 GGRDG-LKTLNTVESLDLNTMAWAPLNAMATPRHGLGVAVLEGPLYAVGGHD--GWSYLNTVERW 436
            ||.:| ...|:..|..|.|...|.|:..:.|.|...||..|.|.||.|||.|  |...|...:.:
Human   428 GGSNGHSDDLSCGEMYDSNIDDWIPVPELRTNRCNAGVCALNGKLYIVGGSDPYGQKGLKNCDVF 492

  Fly   437 DPIARTWSYVAPMSSMRSTAGVAVLGGRLYAVGGRDGSVCHRSIECYDPHTNKWSLLAPMNRRRG 501
            ||:.:.|:..||::..|..:.|..|||.||.:||.:...|..::|.|:|..|.|:|:||||..|.
Human   493 DPVTKLWTSCAPLNIRRHQSAVCELGGYLYIIGGAESWNCLNTVERYNPENNTWTLIAPMNVARR 557

  Fly   502 GVGVTVANGFLYALGGHDCPASNPMVCRTETVERYDPATDTWTLICSLALGRDAIGCALLGDRLI 566
            |.||.|.||.|:..||.|  .|:.:.|    ||.|||..:.|.::.::...|...|.|.:|:.:.
Human   558 GAGVAVLNGKLFVCGGFD--GSHAISC----VEMYDPTRNEWKMMGNMTSPRSNAGIATVGNTIY 616

  Fly   567 VVGGYDGNHALKSVEEYDPVRNGWN 591
            .|||:|||..|.:||.|:...|.|:
Human   617 AVGGFDGNEFLNTVEVYNLESNEWS 641

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17754	NP_572549.2	BTB	70..170	CDD:279045	26/99 (26%)
		PHA03098	71..591	CDD:222983	158/621 (25%)
		BACK	179..281	CDD:285009	24/118 (20%)
		Kelch	323..369	CDD:128874	14/45 (31%)
		KELCH repeat	359..402	CDD:276965	15/43 (35%)
		Kelch	370..416	CDD:128874	16/46 (35%)
		KELCH repeat	406..449	CDD:276965	17/44 (39%)
		Kelch	418..463	CDD:128874	16/46 (35%)
		KELCH repeat	453..497	CDD:276965	18/43 (42%)
		Kelch	464..510	CDD:128874	20/45 (44%)
		Kelch_1	499..546	CDD:279660	19/46 (41%)
		KELCH repeat	500..549	CDD:276965	19/48 (40%)
		KELCH repeat	553..596	CDD:276965	16/39 (41%)
		Kelch	564..610	CDD:128874	12/28 (43%)
IVNS1ABP	XP_011507381.1	BTB	22..126	CDD:279045	29/128 (23%)
		PHA03098	23..645	CDD:222983	161/651 (25%)
		BACK	134..229	CDD:197943	20/95 (21%)
		KELCH repeat	365..408	CDD:276965	10/42 (24%)
		Kelch	376..422	CDD:128874	14/45 (31%)
		KELCH repeat	416..458	CDD:276965	13/41 (32%)
		Kelch	423..470	CDD:128874	16/46 (35%)
		Kelch_1	460..506	CDD:279660	18/45 (40%)
		KELCH repeat	460..505	CDD:276965	17/44 (39%)
		KELCH repeat	509..552	CDD:276965	17/42 (40%)
		Kelch	521..566	CDD:128874	20/44 (45%)
		KELCH repeat	556..600	CDD:276965	19/49 (39%)
		Kelch	567..613	CDD:128874	15/51 (29%)
		Kelch_1	602..642	CDD:279660	16/40 (40%)
		KELCH repeat	603..642	CDD:276965	16/39 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4441
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D312716at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820