Protein Alignment CG17754 and klhl21

DIOPT Version :10

• Sequence 1: NP_572549.2
• Gene: CG17754 / 31873
• FlyBaseID: FBgn0030114
• Length: 654
• Species: Drosophila melanogaster
• Sequence 2: XP_002933898.2
• Gene: klhl21 / 100495738
• XenbaseID: XB-GENE-5802687
• Length: 615
• Species: Xenopus tropicalis
• Alignment Length: 560
• Identity: 165/560 - (29%)
• Similarity: 253/560 - (45%)
• Gaps: 61/560 - (10%)

  Fly    57 HADNILKRMQLYVDSQQLCDVVLIAGIDGKRVPAHRLVLSASSAYFSAMFTGSLRETKEQEVTLG 121
            ||.::|:.:......|:..|:.:.||  |:..|.||.||:|:|.||.|||.|.|||:....|.|.
 Frog    28 HALHLLRGINELRAEQKFFDMTVSAG--GQDFPCHRTVLAAASNYFRAMFAGRLRESHVDRVELH 90

  Fly   122 EVHGDALHLLVQYCYTGFIEMREDTVETLLATACLLQLNAVVTACCNFLARQLHPSNCLGFAFFA 186
            :|.|..|.||:.:||||.:.:..:.||.||..|.|.|..:|..|||.:|.:||..||||....||
 Frog    91 DVTGPILSLLLDFCYTGRVTVTLENVEPLLQAADLFQFPSVKEACCAYLEQQLDVSNCLEIQDFA 155

  Fly   187 EQQSCTTLLRLAQAYTCQYFMQVCQNQEFFQLNADQLGKLLSSDDLNVPSEQDVFHSLMSWVRHD 251
            |..:|..|....:.:...:..|:.|..|..:|...::.:.:|.|.|.|..|:..|...:.||:.|
 Frog   156 EAYACQGLAESTKRFILAHMAQLAQAHEVERLTFKRMLEYISDDRLCVDKEEAAFQIALQWVKAD 220

  Fly   252 SAAREQHIPELLALVRLPLLQPAFIMDHVEN---VCNANECQQLVMEAFKWHLMPERRSRIATER 313
            ...|:...|||...:|||.::..:::.:||:   |..:..|.||:.||..:......|......|
 Frog   221 PKHRQYRWPELFQYLRLPFIRRFYLLAYVESDPLVYRSPYCLQLIREARAFQSSEYDRHDWPCHR 285

  Fly   314 TTPRKST--VGRLLAVGGMDAH-KGAISIESYCPRLDKWT-----PWKHMTGRRLQFGAAVMEDK 370
            ..||.||  ...|:.|||.|.. ...::::.|..:..:|.     | .|:.|   .:....:.:.
 Frog   286 MKPRPSTGLAEILVVVGGCDQDCDELVTVDCYNAQTGQWRYLAEFP-DHLGG---GYSITALGND 346

  Fly   371 LILVGGRDGLKTLNTVESLDLNTMAWAPLNAMATPRHGLGVAVLEGPLYAVGGHDGWSYLNTVER 435
            :.:.||.||.:..:.|...:.:...|..::.|...|......||.|.||.:..       ::.||
 Frog   347 IYVTGGSDGSRLYDCVWRYNSSVNEWTEVSPMLKAREYHSSTVLNGLLYVIAS-------DSTER 404

  Fly   436 WDPIARTWSYVAPMSSMRSTAGVAVLGGRLYAVG---GRDGSVCHRSIECYDPHTNKWSLL---- 493
            :||...||..:.||..............:|||:|   |::..|    ::||:|.||.||::
 Frog   405 YDPTMDTWESLRPMLYPMDNCSTTSCRKKLYAIGSLEGKESMV----MQCYNPDTNLWSMVNCGQ 465

  Fly   494 ------APMNRRRGGVGVTVANGFLYALGGHDCPASNPMVCRTETVERYDPATDTWTLICSLALG 552
                  ||..       ||: ||.:|.:  .|..|.         |:.|.|:.:.|..|..:...
 Frog   466 LPPWSFAPKT-------VTL-NGLIYFV--RDDSAE---------VDVYSPSKNEWDKIPPMIQV 511

  Fly   553 RDAIGCALLGDRLIVVGGYDGNHALKS-VEEYDPVRNGWN 591
            ......|.||.:|.|.||||....|.. ||.:||....|:
 Frog   512 HVGGSLAALGGKLYVSGGYDNTFELSDVVEAFDPETRLWS 551

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG17754	NP_572549.2	PHA03098	71..591	CDD:222983	161/544 (30%)
		KELCH repeat	359..402	CDD:276965	6/42 (14%)
		KELCH repeat	406..449	CDD:276965	12/42 (29%)
		KELCH repeat	453..497	CDD:276965	15/56 (27%)
		KELCH repeat	500..549	CDD:276965	12/48 (25%)
		KELCH repeat	553..596	CDD:276965	15/40 (38%)
klhl21	XP_002933898.2	BTB_POZ_KLHL21	25..148	CDD:349559	50/121 (41%)
		PHA03098	43..557	CDD:222983	162/545 (30%)
		BACK_KLHL21	143..243	CDD:350535	30/99 (30%)
		KELCH repeat	336..378	CDD:276965	7/44 (16%)
		KELCH repeat	382..419	CDD:276965	13/43 (30%)
		KELCH repeat	422..461	CDD:276965	13/42 (31%)
		KELCH repeat	512..558	CDD:276965	15/40 (38%)