DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17754 and klhl28

DIOPT Version :9

Sequence 1:	NP_572549.2	Gene:	CG17754 / 31873	FlyBaseID:	FBgn0030114	Length:	654	Species:	Drosophila melanogaster
Sequence 2:	XP_017952205.1	Gene:	klhl28 / 100493680	XenbaseID:	XB-GENE-994648	Length:	573	Species:	Xenopus tropicalis

Alignment Length:	597	Identity:	215/597 - (36%)
Similarity:	329/597 - (55%)	Gaps:	44/597 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 LESLSRDYSLGSLNSAGSQDEFFRCRDHADNILKRMQLYVDSQQLCDVVLIAGIDGKRVPAHRLV 94
            ::..|:.|.|.:|...           |::.:|:.:.|.....:|||:||..|  ..::.||::|
Frog     3 MDQSSQSYMLANLTHL-----------HSEQLLQGLNLLRQHHELCDIVLQVG--DVKIHAHKVV 54

  Fly    95 LSASSAYFSAMFTGSLRETKEQEVTLGEVHGDALHLLVQYCYTGFIEMREDTVETLLATACLLQL 159
            |::.|.||.|||||:|.|.:..:|....|...||..:::|.|||.:.:.::|||:||..|.|||:
Frog    55 LASISPYFKAMFTGNLSEKENSQVEFQSVDEAALQAIIEYAYTGTVFISQETVESLLPAANLLQI 119

  Fly   160 NAVVTACCNFLARQLHPSNCLGFAFFAEQQSCTTLLRLAQAYTCQYFMQVCQNQEFFQLNADQLG 224
            ..|:..||.||..||...||:|.:.|||...|..|...|..|.||.|..|||.:|||:|:..:|.
Frog   120 KLVLKECCAFLESQLDVGNCIGISRFAETYGCHELYLAANKYICQNFEDVCQTEEFFELSNSELH 184

  Fly   225 KLLSSDDLNVPSEQDVFHSLMSWVRHDSAAREQHIPELLALVRLPLLQPAFI-----MDHVENVC 284
            :::|:|.|||.:|:.||::|.||:::|...|::::.:||..||||||...|:     .:|:  :.
Frog   185 EIVSNDCLNVVNEETVFYALESWIKYDVQERQKYLAQLLHCVRLPLLSVKFLTRLYEANHL--IR 247

  Fly   285 NANECQQLVMEAFKWHLMPERRSRIATERTTPRKSTVGRLLAVGGMDAHKGAI-----SIESYCP 344
            :.:.|:.|:.||.|:|.|||.|....|...|..:.....|.||||    |..:     |:|.|.|
Frog   248 DDHTCKHLLNEALKYHFMPEHRLSHQTVLKTQPRCAPKVLCAVGG----KAGLFACLESMEMYFP 308

  Fly   345 RLDKWTPWKHMTGRRLQFGAAVMEDKLILVGG-----RDGL---KTLNTVESLDLNTMAWAPLNA 401
            :.|.|.....:...|.:||...::.|:.:|||     |.|:   |..|:||..|..|..|..:..
Frog   309 QDDSWIGLAPLGSPRYEFGLCTLDQKVYVVGGIATHMRQGINYRKHENSVECWDPVTNKWTSIER 373

  Fly   402 MATPRHGLGVAVLEGPLYAVGGHDGWSYLNTVERWDPIARTWSYVAPMSSMRSTAGVAVLGGRLY 466
            |...|..||..||.|.:||:||:||.|.|.:||::.|.|:.|..||||...||....|||.|.:|
Frog   374 MIECRSTLGAVVLAGEMYALGGYDGQSCLQSVEKYIPKAKEWHPVAPMIKTRSCFAGAVLDGMIY 438

  Fly   467 AVGGRDGSVCHRSIECYDPHTNKWSLLAPMNRRRGGVGVTVANGFLYALGGHDCPASNPMVCRTE 531
            |:||. |.....|:|.|||..:.|.::|.|..:|...||:|..||::.:|||:      .|....
Frog   439 AIGGY-GPAHMNSVERYDPSRDSWEMVASMEDKRINFGVSVMLGFIFVVGGHN------GVAHLS 496

  Fly   532 TVERYDPATDTWTLICSLALGRDAIGCALLGDRLIVVGGYDGNHALKSVEEYDPVRNGWNELAPM 596
            ::|||||..:.||:...:...|..:|.|::.:.|.||||:.|:..|..|::|||:.:.|.::|.|
Frog   497 SIERYDPHQNQWTVCRPMKEPRTGVGAAVVDNYLYVVGGHSGSSYLNYVQKYDPISDTWQDVAGM 561

  Fly   597 AFARAGACVVAI 608
            |::|....:.|:
Frog   562 AYSRCNFGLTAL 573

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17754	NP_572549.2	BTB	70..170	CDD:279045	40/99 (40%)
		PHA03098	71..591	CDD:222983	202/537 (38%)
		BACK	179..281	CDD:285009	43/106 (41%)
		Kelch	323..369	CDD:128874	15/50 (30%)
		KELCH repeat	359..402	CDD:276965	16/50 (32%)
		Kelch	370..416	CDD:128874	19/53 (36%)
		KELCH repeat	406..449	CDD:276965	21/42 (50%)
		Kelch	418..463	CDD:128874	22/44 (50%)
		KELCH repeat	453..497	CDD:276965	18/43 (42%)
		Kelch	464..510	CDD:128874	17/45 (38%)
		Kelch_1	499..546	CDD:279660	17/46 (37%)
		KELCH repeat	500..549	CDD:276965	17/48 (35%)
		KELCH repeat	553..596	CDD:276965	16/42 (38%)
		Kelch	564..610	CDD:128874	17/45 (38%)
klhl28	XP_017952205.1	PHA03098	37..555	CDD:222983	201/532 (38%)
		KELCH repeat	323..374	CDD:276965	16/50 (32%)
		KELCH repeat	378..421	CDD:276965	21/42 (50%)
		KELCH repeat	425..467	CDD:276965	18/42 (43%)
		KELCH repeat	471..515	CDD:276965	17/49 (35%)
		KELCH repeat	518..561	CDD:276965	16/42 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D312716at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920