DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG17754 and klhl17

DIOPT Version :9

Sequence 1:	NP_572549.2	Gene:	CG17754 / 31873	FlyBaseID:	FBgn0030114	Length:	654	Species:	Drosophila melanogaster
Sequence 2:	XP_004916201.1	Gene:	klhl17 / 100491332	XenbaseID:	XB-GENE-977875	Length:	627	Species:	Xenopus tropicalis

Alignment Length:	630	Identity:	257/630 - (40%)
Similarity:	353/630 - (56%)	Gaps:	46/630 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 QKESPSRDSTASTSGHISMLADNTLESLSRDYSLGSLNSAGSQDEFFRCRDHADNILKRMQLYVD 70
            |:..|.::.    ||..|...:..::.|:||....|.||.....:.|.|       :.||:   .
Frog    22 QRVKPVKEK----SGDQSPAMEGAVQLLTRDGHSISHNSKRHYHDAFVC-------MNRMR---Q 72

  Fly    71 SQQLCDVVLIAGIDGKRVPAHRLVLSASSAYFSAMFTGSLRETKEQEVTLGEVHGDALHLLVQYC 135
            ...|||:||..|.  |.:..|::||::.|.||.||||..:.|:::..|||.::...||..||||.
Frog    73 RGLLCDIVLHVGT--KEIKGHKVVLASCSPYFHAMFTNEMSESRQTHVTLHDIDPQALEQLVQYA 135

  Fly   136 YTGFIEMREDTVETLLATACLLQLNAVVTACCNFLARQLHPSNCLGFAFFAEQQSCTTLLRLAQA 200
            ||..|.:.|..|:|||..|.|||||.|..|||.||..||.||||||...||:..||:.||:.|..
Frog   136 YTAEIVVGEGNVQTLLPAASLLQLNGVRDACCKFLLSQLDPSNCLGIRGFADTHSCSDLLKSAHK 200

  Fly   201 YTCQYFMQVCQNQEFFQLNADQLGKLLSSDDLNVPSEQDVFHSLMSWVRHDSAAREQHIPELLAL 265
            |..|:|::|.:.:||..|...|:..|:|||.||||||::|:.::::||:||...|.||:|.|:..
Frog   201 YVLQHFVEVSKTEEFMLLPLKQVLDLISSDSLNVPSEEEVYRAVLNWVKHDVDGRRQHVPRLMKC 265

  Fly   266 VRLPLLQPAFIMDHVEN---VCNANECQQLVMEAFKWHLMPERRSRIATERTTPRK----STVGR 323
            ||||||...|:|..|:.   |.:.:||:.|::||.|:|||||:|..::..||.||:    |||
Frog   266 VRLPLLSRDFLMSSVDTELLVRHHSECKDLLIEALKYHLMPEQRGVLSNSRTRPRRCEGASTV-- 328

  Fly   324 LLAVGGMDAHKGAI-----SIESYCPRLDKWTPWKHMTGRRLQFGAAVMEDKLILVGGRDGLKTL 383
            |.||||     |::     ..|:|..|.|:|.....|:.||.:.|.|.:.:||..|||.||...|
Frog   329 LFAVGG-----GSLFAIHGDCEAYDTRTDRWHMVTSMSTRRARVGVAAIGNKLYAVGGYDGTSDL 388

  Fly   384 NTVESLDLNTMAWAPLNAMATPRHGLGVAVLEGPLYAVGGHDGWSYLNTVERWDPIARTWSYVAP 448
            .||||.|..|..|.|..:|.|.|..||||||.|.|||.||:||.|.||:.||:||:..||:.:|.
Frog   389 ATVESYDPVTNTWQPEVSMGTRRSCLGVAVLHGLLYAAGGYDGASCLNSAERYDPLTGTWTSIAA 453

  Fly   449 MSSMRSTAGVAVLGGRLYAVGGRDGSVCHRSIECYDPHTNKWSLLAPMNRRRGGVGVTVANGFLY 513
            ||:.|....||.|.|.||||||.|.|....::|.|:|..|.|:.:|.|..||...||.|..|.||
Frog   454 MSTRRRYVRVATLDGNLYAVGGYDSSSHLATVEKYEPQINTWTPIANMLSRRSSAGVAVLEGMLY 518

  Fly   514 ALGGHDCPASNPMVCRTETVERYDPATDTWTLICSLALGRDAIGCALLGDRLIVVGGYDGNHALK 578
            ..||:|..:     | ..:||||:|..:||..:..:.:.|.......:...|..|||.||:.:|.
Frog   519 VAGGNDGTS-----C-LNSVERYNPKANTWESVAPMNIRRSTHDLVAMDGWLYAVGGNDGSSSLN 577

  Fly   579 SVEEYDPVRNGWNELAPMAFARAGACVVAIPNVIPPAAQQPPPSA 623
            |:|:|:|..|.| ..|...|.|..:..||:..::    ..||||:
Frog   578 SIEKYNPRTNKW-VAASCMFTRRSSVGVAVLELL----NFPPPSS 617

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17754	NP_572549.2	BTB	70..170	CDD:279045	45/99 (45%)
		PHA03098	71..591	CDD:222983	232/531 (44%)
		BACK	179..281	CDD:285009	46/101 (46%)
		Kelch	323..369	CDD:128874	16/50 (32%)
		KELCH repeat	359..402	CDD:276965	19/42 (45%)
		Kelch	370..416	CDD:128874	25/45 (56%)
		KELCH repeat	406..449	CDD:276965	25/42 (60%)
		Kelch	418..463	CDD:128874	23/44 (52%)
		KELCH repeat	453..497	CDD:276965	19/43 (44%)
		Kelch	464..510	CDD:128874	20/45 (44%)
		Kelch_1	499..546	CDD:279660	19/46 (41%)
		KELCH repeat	500..549	CDD:276965	18/48 (38%)
		KELCH repeat	553..596	CDD:276965	15/42 (36%)
		Kelch	564..610	CDD:128874	18/45 (40%)
klhl17	XP_004916201.1	BTB_POZ_KLHL17_actinfilin	38..176	CDD:349555	59/149 (40%)
		PHA03098	77..543	CDD:222983	217/480 (45%)
		KELCH repeat	321..360	CDD:276965	14/45 (31%)
		KELCH repeat	364..407	CDD:276965	19/42 (45%)
		KELCH repeat	411..454	CDD:276965	25/42 (60%)
		KELCH repeat	458..502	CDD:276965	19/43 (44%)
		KELCH repeat	505..549	CDD:276965	18/49 (37%)
		KELCH repeat	552..597	CDD:276965	15/45 (33%)
		Kelch	564..608	CDD:128874	18/44 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D312716at33208
OrthoFinder	1	1.000	-	-		FOG0000036
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010