DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG17754 and LOC100489128

DIOPT Version :9

Sequence 1:	NP_572549.2	Gene:	CG17754 / 31873	FlyBaseID:	FBgn0030114	Length:	654	Species:	Drosophila melanogaster
Sequence 2:	XP_012809305.2	Gene:	LOC100489128 / 100489128	-ID:	-	Length:	609	Species:	Xenopus tropicalis

Alignment Length:	598	Identity:	180/598 - (30%)
Similarity:	286/598 - (47%)	Gaps:	35/598 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 SLNSAGSQDEFFRCRDHADNILKRMQLYVDSQQLCDVVLIAGIDGKR--VPAHRLVLSASSAYFS 103
            |:...|..|  :...:|.....::|.....:..||||:|....:||.  ...|::||::.|.:|.
Frog    35 SMKGHGYLD--YTIENHTSKAFEKMDEMRRNNLLCDVLLRVSYNGKEEDFHVHKIVLASCSPFFR 97

  Fly   104 AMFTGSLRETKEQEVTLGEVHGDALHLLVQYCYTGFIEMREDTVETLLATACLLQLNAVVTACCN 168
            ||||.:.||...:|||:.::....:..|:::.||..|.:.|..|..:|..|...|:..|..||.:
Frog    98 AMFTNNFRECHAREVTIKDICPKVMQRLIEFAYTSRITVGEKCVLHVLLAAMRYQMEDVAKACSD 162

  Fly   169 FLARQLHPSNCLGFAFFAEQQSCTTLLRLAQAYTCQYFMQVCQNQEFFQLNADQLGKLLSSDDLN 233
            ||.:.|..||.:|.:.||||..|..|.|..:.|...:|.:|...:||..|:..:|..|:|.|.||
Frog   163 FLVKHLDASNVIGISNFAEQIGCHELYRTGREYINTHFSEVTNEEEFLSLSHCELLDLVSQDSLN 227

  Fly   234 VPSEQDVFHSLMSWVRHDSAAREQHIPELLALVRLPLLQPAFIMDHVEN---VCNANECQQLVME 295
            |..|.:|:::.:.|::.|...|.|:...||..|.|..|...|:...::.   :...|.|:..:.:
Frog   228 VLCESEVYNACLKWMQWDLNNRAQYFHALLNAVHLYSLPAKFLEIQLKKCPILSKENRCRVYLSK 292

  Fly   296 AFKWHLMPERRSRIATERTTPR-KSTVGRLLAVGGMDAHKGAISIESYCPRLDKWTPWKHMTGRR 359
            .|:         .:...:..|| |....:|:.|.|........|::::.|:..:|.....|...|
Frog   293 IFQ---------EMCLHKPLPRPKQRGNQLIYVAGGYLQNSLSSMDAFNPQTGEWIKLADMLEPR 348

  Fly   360 LQFGAAVMEDKLILVGGRDGLKTLNTVESL----DLNTMAWAPLNAMATPRHGLGVAVLEGPLYA 420
            ...||.::......||||:.....||...|    :..|..||....|..||:.:|||.::|.:||
Frog   349 SGLGACIVSGLFYAVGGRNNSCQENTDSDLLSFFNPVTNQWASRAPMNVPRNRVGVAEIDGAIYA 413

  Fly   421 VGGHDGWSYLNTVERWDPIARTWSYVAPMSSMRSTAGVAVLGGRLYAVGGRDGSVCHRSIECYDP 485
            .||..|..:..:||::||....|::||||.:.|..|||....||||.|||.||.....:::||||
Frog   414 AGGSCGSEHHKSVEKYDPDNDRWTFVAPMPTARIGAGVVACRGRLYVVGGFDGDTRWNTVDCYDP 478

  Fly   486 HTNKWSLLAPMNRRRGGVGVTVANGFLYALGGHDCPASNPMVCRTETVERYDPATDTWTLICSLA 550
            ..::|..:|.|...|.|.||...:.:|||:||:|  .:|.:    ::||||:...:.|..:..:.
Frog   479 EEDQWQPVASMETIRSGAGVVALDNYLYAVGGYD--GTNQL----DSVERYNIERNYWEAMAPMK 537

  Fly   551 LGRDAIGCALLGDRLIVVGGYDGNHALKSVEEYDPVRNGWNELAPMAFARAGACVVAIPNVIPPA 615
            ..|.|.|..:...::..:||::....|.|||.|.|.||.|.|:..|....:|..|.        .
Frog   538 HRRSAHGLTVHQGKIYALGGFNAGGFLSSVECYCPDRNEWTEVTVMPTGCSGMGVA--------V 594

  Fly   616 AQQPPPSATKKKK 628
            ..:|.|....|.:
Frog   595 TMEPCPQLCDKNE 607

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17754	NP_572549.2	BTB	70..170	CDD:279045	33/101 (33%)
		PHA03098	71..591	CDD:222983	167/529 (32%)
		BACK	179..281	CDD:285009	33/101 (33%)
		Kelch	323..369	CDD:128874	10/45 (22%)
		KELCH repeat	359..402	CDD:276965	13/46 (28%)
		Kelch	370..416	CDD:128874	16/49 (33%)
		KELCH repeat	406..449	CDD:276965	17/42 (40%)
		Kelch	418..463	CDD:128874	18/44 (41%)
		KELCH repeat	453..497	CDD:276965	19/43 (44%)
		Kelch	464..510	CDD:128874	19/45 (42%)
		Kelch_1	499..546	CDD:279660	16/46 (35%)
		KELCH repeat	500..549	CDD:276965	16/48 (33%)
		KELCH repeat	553..596	CDD:276965	15/42 (36%)
		Kelch	564..610	CDD:128874	15/45 (33%)
LOC100489128	XP_012809305.2	BTB_POZ_KLHL19_KEAP1	46..169	CDD:349557	37/122 (30%)
		PHA03098	67..585	CDD:222983	169/532 (32%)
		KELCH repeat	348..395	CDD:276965	13/46 (28%)
		KELCH repeat	399..442	CDD:276965	17/42 (40%)
		KELCH repeat	446..489	CDD:276965	19/42 (45%)
		KELCH repeat	493..537	CDD:276965	16/49 (33%)
		KELCH repeat	540..585	CDD:276965	16/44 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D312716at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010