DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG17754 and ipp

DIOPT Version :9

Sequence 1:	NP_572549.2	Gene:	CG17754 / 31873	FlyBaseID:	FBgn0030114	Length:	654	Species:	Drosophila melanogaster
Sequence 2:	XP_012816160.1	Gene:	ipp / 100327249	XenbaseID:	XB-GENE-491275	Length:	584	Species:	Xenopus tropicalis

Alignment Length:	597	Identity:	181/597 - (30%)
Similarity:	285/597 - (47%)	Gaps:	68/597 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 HADNILKRMQLYVDSQQLCDVVLIAGIDGKRVPAHRLVLSASSAYFSAMFTGSLRETKEQEVTLG 121
            ||..||.:|.......:.|||.:..|  ..:...|:|||:|||.||:|:..|.::|:..:.|.:.
Frog    19 HAQLILAQMNRMRHQLEFCDVQIQIG--DVKFGVHKLVLAASSPYFAALLAGGMKESLTEVVQIQ 81

  Fly   122 EVHGDALHLLVQYCYTGFIEMREDTVETLLATACLLQLNAVVTACCNFLARQLHPSNCLGFAFFA 186
            .::.::..|::.:.|||.:::..|.||.|:..|.:|||:.||..||:||.....|:||:||..||
Frog    82 GLNPNSFQLILDFIYTGSVKISTDNVEDLMTAADMLQLSHVVELCCDFLKEHTEPANCIGFFQFA 146

  Fly   187 EQQSCTTLLRLAQAYTCQYFMQVCQNQEFFQLNADQLGKLLSSDDLNVPSEQDVFHSLMSWVRHD 251
            |..||..||...::|...:|.:|....||..|..|||.::|.|::|::..|..||.:.|.|::.|
Frog   147 EHLSCQPLLEYTESYIHTHFTEVQIGDEFPTLTKDQLVQILQSEELSIEDEYQVFSAAMIWIQKD 211

  Fly   252 SAAREQHIPELLALVRLPLLQPAFIMDHVENVCNAN---ECQQLVMEAFKWHLMPERR---SRIA 310
            ...|::|:.|:|..||..||.|..:...:|:|.:.:   ..|.|:.|..:....|:.:   :.:.
Frog   212 IVTRKRHVIEVLEPVRFSLLPPKRLHKAIEDVADFSLRVALQTLLREYCELSHSPKDKKLCNFLQ 276

  Fly   311 TERTTPRKSTVGRLLAVGGMDAHKGAISIESYCPRLDKWTPWKHMTGRRLQFGAAVMEDKLILVG 375
            |.|..||:.....|.|:||...                                        |:|
Frog   277 TSRVRPRRKARKFLYAIGGYTR----------------------------------------LLG 301

  Fly   376 GR-DGLKTLNTVESLDLNTMAWAPLNAMATPRHGLGVAVLEGPLYAVGGHDGWSYLNTVERWDPI 439
            || ...:.|:.||..|..:..|:.::::...|.|:.||||||.:|.:||.......:.||.:||:
Frog   302 GRWSDSRALSCVERFDTFSQYWSTVSSLHQARSGMSVAVLEGRIYVIGGEKDSMIFDCVECYDPV 366

  Fly   440 ARTWSYVAPMSSMRSTAGVAVLGGRLYAVGGRDGSVCHRSIECYDPHTNKWSLLAPMNRRRGGVG 504
            ::.|:.|:.|:..|...||....|.:||:||..||....|||.:.|..|.|.::..|...|....
Frog   367 SKQWAAVSSMNQPRCGLGVCACHGAIYALGGWVGSEIGNSIERFSPEENAWQVVGSMAVPRYNFA 431

  Fly   505 VTVANGFLYALGG--HDCPASNPMVCRTE--TVERYDPATDTWTLICSLALGRDAIGCALLGDRL 565
            .....|.:|.:||  |:         .||  :.|.|||.|..|..:..:...|..:|.|.|.|.|
Frog   432 CCERQGMIYVVGGISHE---------GTELRSAEVYDPITRRWMSLPPMGTRRAYLGVACLNDCL 487

  Fly   566 IVVGGYDGNH-ALKSVEEYDPVRNGWNELAPMAFARAGACVVAIPNVIPPAAQQPPPSATKKKKW 629
            ..|||.|.:. ||.:||::......|.|:|||...|.|..||::..::..|..:    :.|:...
Frog   488 YAVGGGDDSQDALNTVEKFSFEEEQWVEVAPMKIPRCGVSVVSVNGLLYAAGGR----SIKQNFT 548

  Fly   630 KPVRLDPI-CYN 640
            .||..|.: .||
Frog   549 APVTTDTVEVYN 560

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17754	NP_572549.2	BTB	70..170	CDD:279045	33/99 (33%)
		PHA03098	71..591	CDD:222983	160/531 (30%)
		BACK	179..281	CDD:285009	37/101 (37%)
		Kelch	323..369	CDD:128874	4/45 (9%)
		KELCH repeat	359..402	CDD:276965	9/43 (21%)
		Kelch	370..416	CDD:128874	15/46 (33%)
		KELCH repeat	406..449	CDD:276965	17/42 (40%)
		Kelch	418..463	CDD:128874	13/44 (30%)
		KELCH repeat	453..497	CDD:276965	16/43 (37%)
		Kelch	464..510	CDD:128874	14/45 (31%)
		Kelch_1	499..546	CDD:279660	14/50 (28%)
		KELCH repeat	500..549	CDD:276965	14/52 (27%)
		KELCH repeat	553..596	CDD:276965	17/43 (40%)
		Kelch	564..610	CDD:128874	18/46 (39%)
ipp	XP_012816160.1	BTB_POZ_KLHL27_IPP	17..141	CDD:349565	43/123 (35%)
		PHA03098	30..567	CDD:222983	176/586 (30%)
		KELCH repeat	333..376	CDD:276965	17/42 (40%)
		KELCH repeat	380..424	CDD:276965	16/43 (37%)
		KELCH repeat	427..473	CDD:276965	14/54 (26%)
		KELCH repeat	475..520	CDD:276965	18/44 (41%)
		KELCH repeat	523..574	CDD:276965	11/42 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D312716at33208
OrthoFinder	1	1.000	-	-		FOG0000036
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.010