DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17754 and ivns1abp

DIOPT Version :9

Sequence 1:	NP_572549.2	Gene:	CG17754 / 31873	FlyBaseID:	FBgn0030114	Length:	654	Species:	Drosophila melanogaster
Sequence 2:	XP_012816907.1	Gene:	ivns1abp / 100145550	XenbaseID:	XB-GENE-949332	Length:	665	Species:	Xenopus tropicalis

Alignment Length:	689	Identity:	167/689 - (24%)
Similarity:	286/689 - (41%)	Gaps:	156/689 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 RDSTASTSGHISMLADNTLESLSRDYSLGSLNSAGSQDEFFRCRDHADNILKRMQLYVDSQQLCD 76
            ||...:...|..|:.:            ||||   .:||.|     .::.:.::.....|.|.||
Frog    16 RDCGVAQGTHRKMVPN------------GSLN---FEDEQF-----IESSVAKLNALRKSGQFCD 60

  Fly    77 VVLIAGIDGKRVPAHRLVLSASSAYFSAMFTGSLRETKEQEVTLGEVHG-----------DALHL 130
            |.|  .:.|..:.|||.||:..|.:...:|...           ||.||           ||:.:
Frog    61 VKL--QVCGHEMLAHRAVLACCSPFLFEIFNSD-----------GESHGISLVRFDDLNPDAVEV 112

  Fly   131 LVQYCYTGFIEMREDTVETLLATACLLQLNAVVTACCNFLARQLHPSNCLGFAFFAEQQSCTTLL 195
            |:.|.||..::...|.|:.:.:.|..|:::.|...|.::|..::...:|:.:..|........||
Frog   113 LLNYAYTSQLKAETDLVKDVYSAAKKLKIDRVKQVCGDYLLSKIDVQSCISYRNFVNAMGDWRLL 177

  Fly   196 RLAQAYTCQYFMQVCQNQEFFQLNADQLGKLLSSDDLNVPSEQDVFHSLMSWVRHDSAAREQHIP 260
            .....|..::.:::.:.::|.:|....| :::..:::::||...::..:::||:.......:::.
Frog   178 SKIDNYIQEHLLEISEQEDFLKLPRLNL-EIMLEENVSLPSNGKLYTKVINWVQRSIWENGENLD 241

  Fly   261 ELLALVRL-------PLLQPAFIMDHV----ENVCNANECQQLVME------------------- 295
            .||..|:.       .||..:.:.:|.    :|:       ||:.:
Frog   242 ALLEEVQTLYYSADHKLLDASLLGEHTDAYEDNI-------QLIQKKSPRENNHKNLSSSSSGSL 299

  Fly   296 ---------AFKWHLMPE-------------------------RRSRIATERTTPR--KSTV--- 321
                     ..:|.::..                         |.|.:.:..:|||  ||..
Frog   300 SPTALTQSPKHEWKIIASEKKTNNTYLCLAVLNSMLCVIFLHGRNSPVNSPSSTPRLTKSLSLEI 364

  Fly   322 --------------------------GRLLAVGGMDAHKGAISIESYCPRLDKWTPWKHMTGRRL 360
                                      |:|:|.||.:..:...::|.|.|..|.||....|...|.
Frog   365 QPDDSLERVMSPMHYARSGLGTAELNGKLIAAGGYNREECLRTVECYDPETDIWTFIAPMKTPRA 429

  Fly   361 QFGAAVMEDKLILVGGRDG-LKTLNTVESLDLNTMAWAPLNAMATPRHGLGVAVLEGPLYAVGGH 424
            :|..||:.|.|.:|||.:| ...|:..|..|..:..|..:..:.:.|...||..|.|.||.|||.
Frog   430 RFQMAVLMDHLYVVGGSNGHSDDLSCGEKYDPKSNVWISVPELRSNRCNAGVCALNGKLYVVGGS 494

  Fly   425 D--GWSYLNTVERWDPIARTWSYVAPMSSMRSTAGVAVLGGRLYAVGGRDGSVCHRSIECYDPHT 487
            |  |...|...:.:|||.|.|:..|.::..|..:.|..||.::|.:||.:...|..|:|||:|..
Frog   495 DPYGQKGLKNCDVFDPITRMWTCCAQLNIRRHQSAVCELGNKMYIIGGAESWNCLNSVECYNPEN 559

  Fly   488 NKWSLLAPMNRRRGGVGVTVANGFLYALGGHDCPASNPMVCRTETVERYDPATDTWTLICSLALG 552
            :.|:|:||||..|.|.||.|..|.|:.:||.|  .::.:.|    ||.|||..:.|.::.|:...
Frog   560 DTWTLVAPMNVARRGAGVAVYEGKLFVVGGFD--GTHALSC----VESYDPERNEWKMMGSMTSA 618

  Fly   553 RDAIGCALLGDRLIVVGGYDGNHALKSVEEYDPVRNGWN 591
            |...|...:||::...||:|||..|.::|.|:|....|:
Frog   619 RSNAGMVAVGDQIYAAGGFDGNEFLNTIEVYNPQTEEWS 657

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17754	NP_572549.2	BTB	70..170	CDD:279045	30/110 (27%)
		PHA03098	71..591	CDD:222983	155/628 (25%)
		BACK	179..281	CDD:285009	18/112 (16%)
		Kelch	323..369	CDD:128874	15/45 (33%)
		KELCH repeat	359..402	CDD:276965	14/43 (33%)
		Kelch	370..416	CDD:128874	13/46 (28%)
		KELCH repeat	406..449	CDD:276965	19/44 (43%)
		Kelch	418..463	CDD:128874	17/46 (37%)
		KELCH repeat	453..497	CDD:276965	17/43 (40%)
		Kelch	464..510	CDD:128874	20/45 (44%)
		Kelch_1	499..546	CDD:279660	17/46 (37%)
		KELCH repeat	500..549	CDD:276965	17/48 (35%)
		KELCH repeat	553..596	CDD:276965	14/39 (36%)
		Kelch	564..610	CDD:128874	10/28 (36%)
ivns1abp	XP_012816907.1	BTB_POZ_NS1BP	41..164	CDD:349615	33/140 (24%)
		PHA03098	50..665	CDD:222983	156/635 (25%)
		KELCH repeat	381..424	CDD:276965	11/42 (26%)
		KELCH repeat	428..473	CDD:276965	14/44 (32%)
		KELCH repeat	476..521	CDD:276965	19/44 (43%)
		KELCH repeat	525..568	CDD:276965	16/42 (38%)
		KELCH repeat	572..616	CDD:276965	18/49 (37%)
		KELCH repeat	619..662	CDD:276965	14/39 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D312716at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010