DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17754 and klhl4

DIOPT Version :9

Sequence 1:	NP_572549.2	Gene:	CG17754 / 31873	FlyBaseID:	FBgn0030114	Length:	654	Species:	Drosophila melanogaster
Sequence 2:	NP_001096427.1	Gene:	klhl4 / 100125035	XenbaseID:	XB-GENE-988002	Length:	719	Species:	Xenopus tropicalis

Alignment Length:	606	Identity:	332/606 - (54%)
Similarity:	426/606 - (70%)	Gaps:	22/606 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 PSRDSTASTSG-HISMLADNTLESLSRDYSLGSLNSAGSQDEFFRCRDHADNILKRMQLYVDSQQ 73
            |.....|:|.. |::..:.|            .:|::|| ||:|:..:||:...::|:.|:..:|
Frog   130 PEEHPEAATDRLHVTCSSPN------------RMNASGS-DEYFQSLNHAEQTFRKMENYLQQKQ 181

  Fly    74 LCDVVLIAGIDGKRVPAHRLVLSASSAYFSAMFTGSLRETKEQEVTLGEVHGDALHLLVQYCYTG 138
            ||||:||||  ..::|||||||||.|.||:||||..:||.||:|:.:..|..|||..||.|.|||
Frog   182 LCDVLLIAG--NLKIPAHRLVLSAVSDYFAAMFTNDVREAKEEEIKIEGVDPDALKALVHYAYTG 244

  Fly   139 FIEMREDTVETLLATACLLQLNAVVTACCNFLARQLHPSNCLGFAFFAEQQSCTTLLRLAQAYTC 203
            .:|::|||:|:|||.||||||:.|:..|||||.:|||||||||...|.:.|.|..|||:|.:||.
Frog   245 VLELKEDTIESLLAAACLLQLSQVIDVCCNFLMKQLHPSNCLGIRSFGDAQGCVELLRVAHSYTM 309

  Fly   204 QYFMQVCQNQEFFQLNADQLGKLLSSDDLNVPSEQDVFHSLMSWVRHDSAAREQHIPELLALVRL 268
            ::|::|.:||||..|.|.::.|||||||:|||.|:.:|.:||.||:||...|::.:..||:.:||
Frog   310 EHFIEVIRNQEFLLLPASEIAKLLSSDDINVPDEETIFQALMQWVKHDIQCRQRDLGMLLSYIRL 374

  Fly   269 PLLQPAFIMDHVEN---VCNANECQQLVMEAFKWHLMPERRSRIATERTTPRKSTVGRLLAVGGM 330
            |||.|..:.| :||   ..|..|||:.:|||.|:||:|||||.:.:.||.|||||||.|.|||||
Frog   375 PLLPPQLLAD-LENSPMFANDLECQKFLMEAMKYHLLPERRSMMQSPRTKPRKSTVGALYAVGGM 438

  Fly   331 DAHKGAISIESYCPRLDKWTPWKHMTGRRLQFGAAVMEDKLILVGGRDGLKTLNTVESLDLNTMA 395
            ||.|||.:||.|..|.:.|.....|.|||||||.||:::||.:|||||||||.||||..:..|..
Frog   439 DATKGATTIEKYDLRTNSWIQISTMNGRRLQFGVAVIDNKLYVVGGRDGLKTSNTVECFNPVTKV 503

  Fly   396 WAPLNAMATPRHGLGVAVLEGPLYAVGGHDGWSYLNTVERWDPIARTWSYVAPMSSMRSTAGVAV 460
            |:.:..|:|.||||||||||||:||||||||||||||||||||.||.|:|||.||:.|||.|||.
Frog   504 WSIMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNYVASMSTPRSTVGVAA 568

  Fly   461 LGGRLYAVGGRDGSVCHRSIECYDPHTNKWSLLAPMNRRRGGVGVTVANGFLYALGGHDCPASNP 525
            |..:||||||||||.|.:|:||:||||||||:.:||::|||||||...||||||:||||.||||.
Frog   569 LNSKLYAVGGRDGSSCLKSMECFDPHTNKWSMCSPMSKRRGGVGVATYNGFLYAVGGHDAPASNH 633

  Fly   526 MVCRTETVERYDPATDTWTLICSLALGRDAIGCALLGDRLIVVGGYDGNHALKSVEEYDPVRNGW 590
            ....::.||||||.||.||::..|::.|||:|.:.|||||..||||||...|..||.||...|.|
Frog   634 CSRLSDCVERYDPKTDNWTMVAPLSIPRDAVGVSPLGDRLYAVGGYDGQSYLNIVESYDAQTNEW 698

  Fly   591 NELAPMAFARAGAC--VVAIP 609
            .:...:...|||||  |:.:|
Frog   699 TQDVSLNIGRAGACLEVIKLP 719

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17754	NP_572549.2	BTB	70..170	CDD:279045	58/99 (59%)
		PHA03098	71..591	CDD:222983	309/522 (59%)
		BACK	179..281	CDD:285009	48/101 (48%)
		Kelch	323..369	CDD:128874	26/45 (58%)
		KELCH repeat	359..402	CDD:276965	24/42 (57%)
		Kelch	370..416	CDD:128874	28/45 (62%)
		KELCH repeat	406..449	CDD:276965	38/42 (90%)
		Kelch	418..463	CDD:128874	35/44 (80%)
		KELCH repeat	453..497	CDD:276965	30/43 (70%)
		Kelch	464..510	CDD:128874	31/45 (69%)
		Kelch_1	499..546	CDD:279660	31/46 (67%)
		KELCH repeat	500..549	CDD:276965	30/48 (63%)
		KELCH repeat	553..596	CDD:276965	22/42 (52%)
		Kelch	564..610	CDD:128874	22/48 (46%)
klhl4	NP_001096427.1	BTB_POZ_KLHL4	164..289	CDD:349645	73/126 (58%)
		PHA03098	177..701	CDD:222983	310/526 (59%)
		KELCH repeat	467..510	CDD:276965	24/42 (57%)
		KELCH repeat	514..558	CDD:276965	38/43 (88%)
		KELCH repeat	561..604	CDD:276965	29/42 (69%)
		KELCH repeat	608..657	CDD:276965	30/48 (63%)
		KELCH repeat	661..699	CDD:276965	21/37 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	126	1.000	Domainoid score	I5350
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	691	1.000	Inparanoid score	I676
OMA	1	1.010	-	-		QHG48972
OrthoDB	1	1.010	-	-		D312716at33208
OrthoFinder	1	1.000	-	-		FOG0000036
OrthoInspector	1	1.000	-	-		otm49417
Panther	1	1.100	-	-	O	PTHR24412
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	11.080