DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17754 and keap1b

DIOPT Version :9

Sequence 1:	NP_572549.2	Gene:	CG17754 / 31873	FlyBaseID:	FBgn0030114	Length:	654	Species:	Drosophila melanogaster
Sequence 2:	NP_001106948.1	Gene:	keap1b / 100003679	ZFINID:	ZDB-GENE-080508-1	Length:	593	Species:	Danio rerio

Alignment Length:	636	Identity:	216/636 - (33%)
Similarity:	321/636 - (50%)	Gaps:	91/636 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSAVNQKESPSRDSTASTSGHISMLADNTLESLSRDYSLGSLNSAGSQDEFFRCRDHADNILKRM 65
            ::|....|..:..:.::::||  .:...||||          ::|.:    |...    |.|:|
Zfish     2 LAAAGMTECKAEVTPSASNGH--RVFSYTLES----------HTAAA----FAIM----NELRR- 45

  Fly    66 QLYVDSQQLCDVVLIAGIDGKRV-----------PAHRLVLSASSAYFSAMFTGSLRETKEQEVT 119
                 .:|||||.|       ||           .||::||::||..|.||||..|:|...:.|.
Zfish    46 -----ERQLCDVTL-------RVRYCPLDTHVDFVAHKVVLASSSPVFRAMFTNGLKECGMEVVP 98

  Fly   120 LGEVHGDALHLLVQYCYTGFIEMREDTVETLLATACLLQLNAVVTACCNFLARQLHPSNCLGFAF 184
            :..:|...:..|:::.||..|.:.|..|..::..|.:.|:::||.|||:||..||.|||.:|.|.
Zfish    99 IEGIHPKVMGRLIEFAYTASISVGEKCVIHVMNGAVMYQIDSVVQACCDFLVEQLDPSNAIGIAS 163

  Fly   185 FAEQQSCTTLLRLAQAYTCQYFMQVCQNQEFFQLNADQLGKLLSSDDLNVPSEQDVFHSLMSWVR 249
            ||||..||.|.:.|:.|....|.||...:|||.|:..||..|:|.|:|||..|.:|||:.::||:
Zfish   164 FAEQIGCTELHQKAREYIYMNFSQVATQEEFFTLSHCQLVTLISRDELNVRCESEVFHACVAWVQ 228

  Fly   250 HDSAAREQHIPELLALVRLPLLQPAFIMDHVENVCNANECQQLVMEAFKWHLM-PERRSRIATER 313
            :|...|..::..||..||...|.|.|:              |..:|.|:|... .:..|:|..:.
Zfish   229 YDREERRPYVQALLQAVRCHSLTPHFL--------------QRQLEHFEWDAQSKDYLSQIFRDL 279

  Fly   314 T-----------TPRKSTVGRLL-AVGGMDAHKGAIS-IESYCPRLDKWTPWKHMTGRRLQFGAA 365
            |           ||:   |.:|: .|||.  .:.::| :|::.|....|.....:...|....|.
Zfish   280 TLHKPTKVIPLRTPK---VPQLIYTVGGY--FRQSLSFLEAFNPCSGAWLRLADLQVPRSGLAAC 339

  Fly   366 VMEDKLILVGGR----DGLKTLNTVESLDLNTMAWAPLNAMATPRHGLGVAVLEGPLYAVGGHDG 426
            |:...|..||||    ||....:|::..:.....|.|...|:.||:.:||.|::|.:|||||..|
Zfish   340 VISGLLYAVGGRNNGPDGNMDSHTLDCYNPMNNCWRPCAHMSVPRNRIGVGVIDGMIYAVGGSHG 404

  Fly   427 WSYLNTVERWDPIARTWSYVAPMSSMRSTAGVAVLGGRLYAVGGRDGSVCHR--SIECYDPHTNK 489
            .::.|:|||:||...:|..|:||.:.|...||||:...||||||.||:  ||  |.|||:|..::
Zfish   405 CTHHNSVERYDPERDSWQLVSPMLTRRIGVGVAVINRLLYAVGGFDGT--HRLSSAECYNPERDE 467

  Fly   490 WSLLAPMNRRRGGVGVTVANGFLYALGGHDCPASNPMVCRTETVERYDPATDTWTLICSLALGRD 554
            |..:|.||..|.|.||.....::|.:||:|  .:|.:    .||||||...|:|:...|:...|.
Zfish   468 WRSIAAMNTVRSGAGVCALGNYIYVMGGYD--GTNQL----NTVERYDVEKDSWSFSASMRHRRS 526

  Fly   555 AIGCALLGDRLIVVGGYDGNHALKSVEEYDPVRNGWNELAPMAFARAGACV 605
            |:|......|:.|:||||||..|.|||.:||..:.|.|:..|...|:|..|
Zfish   527 ALGVTTHHGRIYVLGGYDGNTFLDSVECFDPETDSWTEVTHMKSGRSGVGV 577

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17754	NP_572549.2	BTB	70..170	CDD:279045	36/110 (33%)
		PHA03098	71..591	CDD:222983	197/550 (36%)
		BACK	179..281	CDD:285009	41/101 (41%)
		Kelch	323..369	CDD:128874	11/47 (23%)
		KELCH repeat	359..402	CDD:276965	13/46 (28%)
		Kelch	370..416	CDD:128874	16/49 (33%)
		KELCH repeat	406..449	CDD:276965	19/42 (45%)
		Kelch	418..463	CDD:128874	21/44 (48%)
		KELCH repeat	453..497	CDD:276965	22/45 (49%)
		Kelch	464..510	CDD:128874	23/47 (49%)
		Kelch_1	499..546	CDD:279660	17/46 (37%)
		KELCH repeat	500..549	CDD:276965	17/48 (35%)
		KELCH repeat	553..596	CDD:276965	19/42 (45%)
		Kelch	564..610	CDD:128874	20/42 (48%)
keap1b	NP_001106948.1	BTB_POZ_KLHL19_KEAP1	29..154	CDD:349557	47/155 (30%)
		PHA03098	69..563	CDD:222983	189/520 (36%)
		BACK_KLHL19_KEAP1	152..242	CDD:350533	39/89 (44%)
		KELCH repeat	333..380	CDD:276965	13/46 (28%)
		KELCH repeat	384..427	CDD:276965	19/42 (45%)
		KELCH repeat	431..474	CDD:276965	22/44 (50%)
		KELCH repeat	478..522	CDD:276965	18/49 (37%)
		KELCH repeat	525..570	CDD:276965	20/44 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4441
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D312716at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820