DRSC/TRiP Functional Genomics Resources

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Protein Alignment Takl1 and MAP3K21

DIOPT Version :10

Sequence 1:NP_732554.1 Gene:Takl1 / 318725 FlyBaseID:FBgn0046689 Length:393 Species:Drosophila melanogaster
Sequence 2:NP_115811.2 Gene:MAP3K21 / 84451 HGNCID:29798 Length:1036 Species:Homo sapiens


Alignment Length:414 Identity:119/414 - (28%)
Similarity:189/414 - (45%) Gaps:62/414 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 VDFAEVKLSEKFLGAGSGGAVRKATFQNQEIAVKIFDFLEE----TIKKNAEREITHLSEIDHEN 65
            |.|..::|.| .:|||..|.|.:||:|.||:|||......|    ...::..||....:.:.|.|
Human   119 VAFERLELKE-LIGAGGFGQVYRATWQGQEVAVKAARQDPEQDAAAAAESVRREARLFAMLRHPN 182

  Fly    66 VIRVIGRASNGKKDYLLMEYLEEGSLHNYL----YGDDKWEYTVEQA--------VRWALQCAKA 118
            :|.:.|.........|::|:...|:|:..|    ...|.......:|        |.||:|.|:.
Human   183 IIELRGVCLQQPHLCLVLEFARGGALNRALAAANAAPDPRAPGPRRARRIPPHVLVNWAVQIARG 247

  Fly   119 LAYLH-SLDRPIVHRDIKPQNMLLYN--QHED-----LKICDFGLATDM-SNNKTDMQGTLRYMA 174
            :.||| ....||:|||:|..|:||..  :|:|     |||.|||||.:. ...|....||..:||
Human   248 MLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREWHRTTKMSTAGTYAWMA 312

  Fly   175 PEAIKHLKYTAKCDVYSFGIMLWELMTRQLPYSHLENPNSQYAIMKAISSGEKLPMEAVRSDCPE 239
            ||.||...::...|::|:|::||||:|.::||..::.....|.:  |::   ||.: .:.|.|||
Human   313 PEVIKSSLFSKGSDIWSYGVLLWELLTGEVPYRGIDGLAVAYGV--AVN---KLTL-PIPSTCPE 371

  Fly   240 GIKQLMECCMDINPEKRPSMKEIEKFLGEQYESGTDEDFIKPLDEDTVAVVTYHVDSSGSRIMRV 304
            ...:||:.|...:|..|||...|                ::.|.....||:|.....|...:.  
Human   372 PFAKLMKECWQQDPHIRPSFALI----------------LEQLTAIEGAVMTEMPQESFHSMQ-- 418

  Fly   305 DFWRHQLPSIRMTFPIVKREAERLGKTVVREMAKAAAD--GDREV--RRAEKDTERETSRAAHNG 365
            |.|:.:   |:..|..::.:.:.| ::...|:.:||..  ...|:  ||.::..|||....    
Human   419 DDWKLE---IQQMFDELRTKEKEL-RSREEELTRAALQQKSQEELLKRREQQLAEREIDVL---- 475

  Fly   366 ERETRRAGQDVGRETVRAVKKIGK 389
            |||.......:.:|..:..|:.||
Human   476 ERELNILIFQLNQEKPKVKKRKGK 499

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Takl1NP_732554.1 STKc_TAK1 17..274 CDD:270960 89/281 (32%)
MAP3K21NP_115811.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..36
SH3_MLK4 42..97 CDD:212991
Protein Kinases, catalytic domain 129..401 CDD:473864 90/293 (31%)
Leucine-zipper 1 425..446 3/21 (14%)
Leucine-zipper 2 460..481 8/24 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 517..551
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 748..791
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 923..954
Blue background indicates that the domain is not in the aligned region.

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