Protein Alignment Takl1 and MAP3K12

DIOPT Version :10

• Sequence 1: NP_732554.1
• Gene: Takl1 / 318725
• FlyBaseID: FBgn0046689
• Length: 393
• Species: Drosophila melanogaster
• Sequence 2: NP_001180440.1
• Gene: MAP3K12 / 7786
• HGNCID: 6851
• Length: 892
• Species: Homo sapiens
• Alignment Length: 364
• Identity: 111/364 - (30%)
• Similarity: 177/364 - (48%)
• Gaps: 63/364 - (17%)

  Fly     4 QVDFAEVKLSEKFLGAGSGGAVRKATFQNQEIAVKIFDFLEETIKKNAEREITHLSEIDHENVIR 68
            :|.|.|: |..:::|:|:.|||....|..:|:|||....|:||       :|.||.::.|.|:|.
Human   152 EVPFEEI-LDLQWVGSGAQGAVFLGRFHGEEVAVKKVRDLKET-------DIKHLRKLKHPNIIT 208

  Fly    69 VIGRASNGKKDYLLMEYLEEGSLHNYLYGDDKWEYTVEQAVRWALQCAKALAYLHSLDRPIVHRD 133
            ..|..:......:|||:..:|.|:..|....  ..|....|.|::..|..:.|||.  ..|:|||
Human   209 FKGVCTQAPCYCILMEFCAQGQLYEVLRAGR--PVTPSLLVDWSMGIAGGMNYLHL--HKIIHRD 269

  Fly   134 IKPQNMLLYNQHED-LKICDFGLATDMSNNKTDMQ--GTLRYMAPEAIKHLKYTAKCDVYSFGIM 195
            :|..|||:  .::| :||.|||.:.::|:..|.|.  ||:.:||||.|::...:.|.|::|||::
Human   270 LKSPNMLI--TYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVV 332

  Fly   196 LWELMTRQLPYSHLENPNSQYAIMKAISSGE-KLPMEAVRSDCPEGIKQLMECCMDINPEKRPSM 259
            ||||:|.::||..:::.    ||:..:.|.. .||   |.|.||:|.|.|:..|.:..|..|||.
Human   333 LWELLTGEIPYKDVDSS----AIIWGVGSNSLHLP---VPSSCPDGFKILLRQCWNSKPRNRPSF 390

  Fly   260 KEIEKFL---GEQYESGTDEDFIKPLDEDTVAVVTYHVDSSGSRIMRVDFWRHQLPSIRMTFPIV 321
            ::|...|   .....|...|.:.|...|                      ||.:   :::.|..:
Human   391 RQILLHLDIASADVLSTPQETYFKSQAE----------------------WREE---VKLHFEKI 430

  Fly   322 KREA---ERLGKTVV---REMAKAAAD----GDREVRRA 350
            |.|.   .||.:.:|   ||..:.|.|    .:|::.||
Human   431 KSEGTCLHRLEEELVMRRREELRHALDIREHYERKLERA 469

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Takl1	NP_732554.1	STKc_TAK1	17..274	CDD:270960	89/263 (34%)
MAP3K12	NP_001180440.1	STKc_MAP3K12_13	164..400	CDD:270961	88/255 (35%)