Protein Alignment Takl1 and BLK

DIOPT Version :10

• Sequence 1: NP_732554.1
• Gene: Takl1 / 318725
• FlyBaseID: FBgn0046689
• Length: 393
• Species: Drosophila melanogaster
• Sequence 2: XP_011542126.1
• Gene: BLK / 640
• HGNCID: 1057
• Length: 531
• Species: Homo sapiens
• Alignment Length: 303
• Identity: 76/303 - (25%)
• Similarity: 144/303 - (47%)
• Gaps: 63/303 - (20%)

  Fly    17 LGAGSGGAVRKATFQ-NQEIAVKIFDFLEETIKKNAEREITHLSE------IDHENVIRVIGRAS 74
            ||:|..|.|....:: |.::|:|       |:|:........|.|      :.||.::|:....:
Human   247 LGSGQFGEVWMGYYKNNMKVAIK-------TLKEGTMSPEAFLGEANVMKALQHERLVRLYAVVT 304

  Fly    75 NGKKDYLLMEYLEEGS--------------------------LHNYLYGDDKWEYTVEQAVRWAL 113
            . :..|::.||:..|.                          |.::|..|:....::.:.:..:.
Human   305 K-EPIYIVTEYMARGGAPRRAASSERGGRAGLSRRRRVRCGCLLDFLKTDEGSRLSLPRLIDMSA 368

  Fly   114 QCAKALAYLHSLDRPIVHRDIKPQNMLLYNQHEDL--KICDFGLATDMSNNKTDMQGT---LRYM 173
            |.|:.:||:..::.  :|||::..|:|:   .|.|  ||.|||||..:.:..|..:|.   :::.
Human   369 QIAEGMAYIERMNS--IHRDLRAANILV---SEALCCKIADFGLARIIDSEYTAQEGAKFPIKWT 428

  Fly   174 APEAIKHLKYTAKCDVYSFGIMLWELMT-RQLPYSHLENPNSQYAIMKAISSGEKLPMEAVRSD- 236
            |||||....:|.|.||:|||::|.|::| .::||..:.||.    :::.:..|.::|    |.|
Human   429 APEAIHFGVFTIKADVWSFGVLLMEVVTYGRVPYPGMSNPE----VIRNLERGYRMP----RPDT 485

  Fly   237 C-PEGIKQLMECCMDINPEKRPSMKEIEKFLGEQYESGTDEDF 278
            | ||..:.::..|....||:||:.:.::..| |.:.:.|:..:
Human   486 CPPELYRGVIAECWRSRPEERPTFEFLQSVL-EDFYTATERQY 527

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Takl1	NP_732554.1	STKc_TAK1	17..274	CDD:270960	75/297 (25%)
BLK	XP_011542126.1	SH3_Blk	62..115	CDD:212942
		SH2_Src_Blk	120..219	CDD:198234
		Protein Kinases, catalytic domain	233..522	CDD:473864	75/296 (25%)