Protein Alignment Takl1 and Ripk3

DIOPT Version :10

• Sequence 1: NP_732554.1
• Gene: Takl1 / 318725
• FlyBaseID: FBgn0046689
• Length: 393
• Species: Drosophila melanogaster
• Sequence 2: NP_064339.2
• Gene: Ripk3 / 56532
• MGIID: 2154952
• Length: 486
• Species: Mus musculus
• Alignment Length: 411
• Identity: 109/411 - (26%)
• Similarity: 177/411 - (43%)
• Gaps: 82/411 - (19%)

  Fly     2 VKQVDFAEVKLSEKFLGAGSGGAVRKATFQ--NQEIAVKIFDFLEETIKKNAEREITHLSEIDHE 64
            |..|...|:|..| |:|.|..|.|.:|..:  |.::||||.:      .|....|:..:..:.:|
Mouse    14 VPLVSREELKKLE-FVGKGGFGVVFRAHHRTWNHDVAVKIVN------SKKISWEVKAMVNLRNE 71

  Fly    65 NVIRVIGRASNGKKDY-----LLMEYLEEGSLHNYLYGDDKWEYTVEQAVRWALQC------AKA 118
            ||:.::|...:.:.|:     |:..::|.|||...|        ..|....|.|.|      ...
Mouse    72 NVLLLLGVTEDLQWDFVSGQALVTRFMENGSLAGLL--------QPECPRPWPLLCRLLQEVVLG 128

  Fly   119 LAYLHSLDRPIVHRDIKPQNMLLYNQHEDLKICDFGLATDMSNNKT---------DMQGTLRYMA 174
            :.|||||:.|::|||:||.|:|| :.....|:.||||:|....:::         |..|||.|:.
Mouse   129 MCYLHSLNPPLLHRDLKPSNILL-DPELHAKLADFGLSTFQGGSQSGSGSGSGSRDSGGTLAYLD 192

  Fly   175 PEAI--KHLKYTAKCDVYSFGIMLWELMTRQLPYSHLENPNSQYAIMKAISSGE------KLPME 231
            ||.:  .:||.:...|||||||::|.::..:    ..|..:....|.:.:...:      :||..
Mouse   193 PELLFDVNLKASKASDVYSFGILVWAVLAGR----EAELVDKTSLIRETVCDRQSRPPLTELPPG 253

  Fly   232 AVRSDCPEGIKQLMECCMDINPEKRPSMKEIEKFLGEQYESGTDEDFIKPLDEDTVAVVTYHVD- 295
            :..:...|.:|:||..|.....|.|||.::.|....|.|      :.:|...:..|:.|.:::.
Mouse   254 SPETPGLEKLKELMIHCWGSQSENRPSFQDCEPKTNEVY------NLVKDKVDAAVSEVKHYLSQ 312

  Fly   296 --SSGSRIMRVDFWRHQLPSIR---MTFP---IVKREAERL----------GKTVVREMAKAAAD 342
              |||..:...:      ||.|   |..|   :|.:..:||          ||...|: |:..:.
Mouse   313 HRSSGRNLSARE------PSQRGTEMDCPRETMVSKMLDRLHLEEPSGPVPGKCPERQ-AQDTSV 370

  Fly   343 GDREVRRAEKDTERETSRAAH 363
            |.....|...|....|.:..|
Mouse   371 GPATPARTSSDPVAGTPQIPH 391

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Takl1	NP_732554.1	STKc_TAK1	17..274	CDD:270960	80/286 (28%)
Ripk3	NP_064339.2	Protein Kinases, catalytic domain	28..284	CDD:473864	77/274 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	312..333		6/26 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	349..388		8/39 (21%)
		RHIM	438..457	CDD:463679
		RIP homotypic interaction motif (RHIM). /evidence=ECO:0000269|PubMed:18442983	440..461
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	462..486