DRSC/TRiP Functional Genomics Resources

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Protein Alignment Takl1 and MAP3K10

DIOPT Version :10

Sequence 1:NP_732554.1 Gene:Takl1 / 318725 FlyBaseID:FBgn0046689 Length:393 Species:Drosophila melanogaster
Sequence 2:XP_011525283.1 Gene:MAP3K10 / 4294 HGNCID:6849 Length:962 Species:Homo sapiens


Alignment Length:423 Identity:122/423 - (28%)
Similarity:198/423 - (46%) Gaps:70/423 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 KQVDFAEVKLSEKFLGAGSGGAVRKATFQNQEIAVKIFDF-LEETIKKNAE---REITHLSEIDH 63
            :::.|.|::| |:.:|.|..|.|.:|.::.:|:|||.... .|:.....||   :|......:.|
Human    91 QEIPFHELQL-EEIIGVGGFGKVYRALWRGEEVAVKAARLDPEKDPAVTAEQVCQEARLFGALQH 154

  Fly    64 ENVIRVIGRASNGKKDYLLMEYLEEGSLHNYLYGDDKWEYTVEQAVRWALQCAKALAYLHS-LDR 127
            .|:|.:.|...|.....|:|||...|:|...|.|.....:.:   |.||:|.|:.:.|||: ...
Human   155 PNIIALRGACLNPPHLCLVMEYARGGALSRVLAGRRVPPHVL---VNWAVQVARGMNYLHNDAPV 216

  Fly   128 PIVHRDIKPQNMLLYNQHED-------LKICDFGLATDM-SNNKTDMQGTLRYMAPEAIKHLKYT 184
            ||:|||:|..|:|:....|:       |||.|||||.:. ...|....||..:||||.|:...::
Human   217 PIIHRDLKSINILILEAIENHNLADTVLKITDFGLAREWHKTTKMSAAGTYAWMAPEVIRLSLFS 281

  Fly   185 AKCDVYSFGIMLWELMTRQLPYSHLENPNSQYAI-MKAISSGEKLPMEAVRSDCPEGIKQLMEC- 247
            ...||:|||::||||:|.::||..::.....|.: |..::    ||   :.|.|||...:|:|. 
Human   282 KSSDVWSFGVLLWELLTGEVPYREIDALAVAYGVAMNKLT----LP---IPSTCPEPFARLLEGE 339

  Fly   248 -------CMDINPEKRPSMKEIEKFLGEQYESGTDEDFIKPLDEDTVAVVTYHVDSSGSRIMRVD 305
                   |.|.:|..||....|.|.|....:|..   |..||:       ::|       .::.|
Human   340 PGPRDEECWDPDPHGRPDFGSILKRLEVIEQSAL---FQMPLE-------SFH-------SLQED 387

  Fly   306 FWRHQLPSIRMTFPIVKREAERLGKTVVREMAKAAAD---GDREVRRAEKD-TERETSRAAHNGE 366
             |:.:   |:..|..::.:.:.| ::...|:.:||.:   .:.::||.|:: .|||....    |
Human   388 -WKLE---IQHMFDDLRTKEKEL-RSREEELLRAAQEQRFQEEQLRRREQELAEREMDIV----E 443

  Fly   367 RETRRAGQDVGRETVRAVKKIGK-------KLR 392
            ||.......:.:|..|..|:.|.       |||
Human   444 RELHLLMCQLSQEKPRVRKRKGNFKRSRLLKLR 476

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Takl1NP_732554.1 STKc_TAK1 17..274 CDD:270960 90/278 (32%)
MAP3K10XP_011525283.1 SH3_MLK1-3 20..76 CDD:212992
Protein Kinases, catalytic domain 103..368 CDD:473864 89/274 (32%)
Blue background indicates that the domain is not in the aligned region.

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